-
公开(公告)号：US20100204200A1
公开(公告)日：2010-08-12
申请号：US12764772
申请日：2010-04-21
申请人： Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
发明人： Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
IPC分类号： A61K31/5377 , C07D413/12 , C07D295/145 , C07D413/14 , C07C245/00 , C07D401/12 , C07D403/12 , A61K31/5375 , A61K31/54 , A61K31/496 , A61K31/404
CPC分类号： C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula 1: wherein Q is an optionally substituted azetidinyl, pyrrolidinyl, piperidyl, and indolinyl; or Q is NR25R26; and A, R5, R6, R7, R8, R9, R25, R26 and Ar are substituents.
摘要翻译： 本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。更具体地，本发明提供了具有式1的化合物：其中Q是任选取代的氮杂环丁烷基，吡咯烷基，哌啶基和二氢吲哚基; 或Q为NR25R26; A，R 5，R 6，R 7，R 8，R 9，R 25，R 26和Ar为取代基。
-
公开(公告)号：US07314872B2
公开(公告)日：2008-01-01
申请号：US10922515
申请日：2004-08-18
申请人： Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
发明人： Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
IPC分类号： C07D413/12 , C07D295/10 , A61K31/5377 , A61K31/5375
CPC分类号： C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula I: wherein Q is morpholinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.
摘要翻译： 本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。更具体地，本发明提供具有式I的化合物：其中Q是吗啉基; 和A，R 5，R 6，R 7，R 8，R 9， SUP>和Ar是取代基。
-
公开(公告)号：US07501408B2
公开(公告)日：2009-03-10
申请号：US11932679
申请日：2007-10-31
申请人： Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
发明人： Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
IPC分类号： C07D417/12 , C07D295/10 , A61K31/541
CPC分类号： C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula (I): wherein Q is thiomorpholinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.
摘要翻译： 本发明提供了用于选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。更具体地，本发明提供具有式（I）的化合物：其中Q是硫代吗啉基; A，R5，R6，R7，R8，R9和Ar为取代基。
-
公开(公告)号：US07985749B2
公开(公告)日：2011-07-26
申请号：US11568459
申请日：2005-04-29
申请人： Hong Liu , David C. Tully , Arnab Chatterjee , Phillip B. Alper , David H. Woodmansee , Daniel Mutnick
发明人： Hong Liu , David C. Tully , Arnab Chatterjee , Phillip B. Alper , David H. Woodmansee , Daniel Mutnick
IPC分类号： A61K31/5355 , C07D413/12
CPC分类号： C07D263/56 , C07D211/66 , C07D273/02 , C07D277/64 , C07D295/185 , C07D307/30
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与组织蛋白酶S活性相关的疾病或病症的方法。
-
公开(公告)号：US08268996B2
公开(公告)日：2012-09-18
申请号：US13161555
申请日：2011-06-16
申请人： Hong Liu , David C. Tully , Arnab Chatterjee , Phillip B. Alper , David H. Woodmansee , Daniel Mutnick
发明人： Hong Liu , David C. Tully , Arnab Chatterjee , Phillip B. Alper , David H. Woodmansee , Daniel Mutnick
IPC分类号： C07D413/12 , C07D295/185 , A61K31/5377 , A61K31/5375
CPC分类号： C07D263/56 , C07D211/66 , C07D273/02 , C07D277/64 , C07D295/185 , C07D307/30
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cathepsin S.
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与组织蛋白酶S活性相关的疾病或病症的方法。
-
公开(公告)号：US07732449B2
公开(公告)日：2010-06-08
申请号：US12361287
申请日：2009-01-28
IPC分类号： C07D295/145 , C07D403/12 , A61K31/496
CPC分类号： C07D209/08 , C07D261/14 , C07D295/18 , C07D295/20
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula 1: wherein Q is an optionally substituted piperazinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.
摘要翻译： 本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。更具体地，本发明提供具有式1的化合物：其中Q是任选取代的哌嗪基; A，R5，R6，R7，R8，R9和Ar为取代基。
-
7.发明申请COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY 失效化合物和组合物作为CANNABINOID受体1活性的抑制剂公开(公告)号：US20090247517A1
公开(公告)日：2009-10-01
申请号：US11718016
申请日：2005-10-26
申请人： Hong Liu , Xiaohui He , Ha-Soon Choi , Kunyong Yang , David H. Woodmansee , Zhicheng Wang , David Archer Ellis , Baogen Wu , Yun He , Truc Ngoc Nguyen
发明人： Hong Liu , Xiaohui He , Ha-Soon Choi , Kunyong Yang , David H. Woodmansee , Zhicheng Wang , David Archer Ellis , Baogen Wu , Yun He , Truc Ngoc Nguyen
IPC分类号： A61K31/5377 , C07D487/02 , A61K31/519 , C07D471/02 , A61K31/437 , C07D473/30 , A61K31/522 , C07D413/14 , A61K31/496 , C07D413/02 , A61P3/04
CPC分类号： C07D487/04 , C07D471/04 , C07D473/30 , C07D498/04
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与大麻素受体1（CB1）的活性相关的疾病或病症的方法。
-
8.发明申请COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY 审中-公开化合物和组合物作为CANNABINOID受体1活性的抑制剂公开(公告)号：US20120225869A1
公开(公告)日：2012-09-06
申请号：US13415565
申请日：2012-03-08
申请人： Hong Liu , Xiaohui He , Ha-Soon Choi , Kunyong Yang , David H. Woodmansee , Zhicheng Wang , David Archer Ellis , Boagen Wu , Yun He , Truc Ngoc Nguyen
发明人： Hong Liu , Xiaohui He , Ha-Soon Choi , Kunyong Yang , David H. Woodmansee , Zhicheng Wang , David Archer Ellis , Boagen Wu , Yun He , Truc Ngoc Nguyen
IPC分类号： A61K31/519 , C07D473/30 , A61P3/04 , A61K31/4985 , A61K31/5377 , C07D487/04 , A61K31/522
CPC分类号： C07D487/04 , C07D471/04 , C07D473/30 , C07D498/04
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与大麻素受体1（CB1）的活性相关的疾病或病症的方法。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.042 秒)
