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公开(公告)号：US06569638B1
公开(公告)日：2003-05-27
申请号：US09517734
申请日：2000-03-03
申请人： I. Bernard Weinstein , W. Joseph Thompson , Jae-Won Soh , Li Liu , Han Li
发明人： I. Bernard Weinstein , W. Joseph Thompson , Jae-Won Soh , Li Liu , Han Li
IPC分类号： C12Q148
CPC分类号： G01N33/5011
摘要： This invention provides a method to identify compounds potentially useful for the treatment and prevention of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with its ability to elevate JNK kinase activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibition, an ability to elevate JNK kinase activity, growth inhibition and apoptosis induction are desirable for the treatment of neoplasia.
摘要翻译： 本发明提供了一种鉴定潜在可用于治疗和预防哺乳动物瘤形成的化合物的方法。 测定化合物的磷酸二酯酶抑制活性及其提高JNK激酶活性的能力。 还测定了对培养的肿瘤细胞的生长抑制和凋亡诱导作用。 表现出磷酸二酯酶抑制，提高JNK激酶活性的能力，生长抑制和细胞凋亡诱导的化合物对于治疗瘤形成是理想的。
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公开(公告)号：US07407675B2
公开(公告)日：2008-08-05
申请号：US10746960
申请日：2003-12-23
IPC分类号： A61K36/28
CPC分类号： A61K45/06 , A61K31/704 , A61K36/71 , A61K2300/00
摘要： The present invention provides a composition for use in treating or preventing neoplasia, comprising an effective actein. The present invention also provides a composition for use in treating or preventing neoplasia, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh. The present invention further provides a combination of anti-neoplastic agents, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh and an effective anti-neoplastic amount of at least one additional chemopreventive or chemotherapeutic agent. Methods for treating and preventing neoplasia are also provided.
摘要翻译： 本发明提供了用于治疗或预防肿瘤形成的组合物，其包含有效的actein。 本发明还提供了用于治疗或预防瘤形成的组合物，其包含有效的抗肿瘤量的黑加索的乙酸乙酯萃取物。 本发明还提供抗肿瘤剂的组合，其包含有效的抗肿瘤量的黑色高原的乙酸乙酯提取物和有效抗肿瘤量的至少一种另外的化学预防或化学治疗剂。 还提供了治疗和预防肿瘤的方法。
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公开(公告)号：US20090264377A1
公开(公告)日：2009-10-22
申请号：US12288599
申请日：2008-10-21
申请人： Linda Saxe Einbond , Morando Soffritti , Kyle Louis Kolaja , Richard John Brennan , I. Bernard Weinstein , Joan Weinstein , Tamara Weinstein , Claudia Weinstein , Matthew Weinstein
发明人： Linda Saxe Einbond , Morando Soffritti , Kyle Louis Kolaja , Richard John Brennan , I. Bernard Weinstein , Joan Weinstein , Tamara Weinstein , Claudia Weinstein , Matthew Weinstein
IPC分类号： A61K31/7048 , A61P35/00 , A61K31/366 , A61K31/4418 , A61K31/40 , A61K31/404 , A61K31/337
CPC分类号： A61K31/704 , A61K31/7048 , A61K36/71 , A61K45/06 , A61K2300/00
摘要： A method is provided for treating, preventing or ameliorating neoplasia in a subject. This method includes administering to the subject an amount of actein or an amount of an extract of black cohosh that contains a triterpene glycoside, which amount of the actein or black cohosh is effective to treat, prevent or ameliorate the neoplasia, in combination with an amount of a statin which is effective to treat, prevent, or ameliorate the neoplasia. Related methods for treating, preventing or ameliorating breast cancer, or liver cell neoplasia are also provided. In addition, methods for modulating a cholesterol biosynthesis pathway and a stress response pathway in a subject are provided. These methods include administering to a subject a composition comprising an anti-neoplastic synergistic amount of a statin and actein. Compositions for carrying out such methods are also provided.
摘要翻译： 提供一种用于治疗，预防或改善受试者中的瘤形成的方法。 该方法包括向受试者施用一定量的肌动蛋白或含有三萜糖苷的黑加索提取物的量，所述三萜糖苷的量与所述肌动蛋白或黑加索的量有效地用于治疗，预防或改善瘤形成， 的他汀类药物有效治疗，预防或改善肿瘤。 还提供了治疗，预防或改善乳腺癌或肝细胞瘤形成的相关方法。 此外，提供了调节受试者中胆固醇生物合成途径和应激反应途径的方法。 这些方法包括向受试者施用包含抗肿瘤协同量的他汀和actein的组合物。 还提供了用于实施这些方法的组合物。
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公开(公告)号：US20120219643A1
公开(公告)日：2012-08-30
申请号：US13440496
申请日：2012-04-05
申请人： Linda Saxe Einbond , Morando Soffritti , I. Bernard Weinstein , Joan Weinstein , Tamara Weinstein , Claudia Weinstein , Matthew Weinstein
发明人： Linda Saxe Einbond , Morando Soffritti , I. Bernard Weinstein , Joan Weinstein , Tamara Weinstein , Claudia Weinstein , Matthew Weinstein
IPC分类号： A61K36/71 , C12N5/09 , C12N5/071 , A61P35/00 , A61K31/7048
CPC分类号： A61K31/7048 , A61K36/71 , A61K45/06 , A61K2300/00
摘要： A method for treating, preventing or ameliorating breast cancer is provided by administering a synergistic amount of digitoxin and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be paclitaxel. Methods for treating or preventing a neoplasia using a synergistic combination, and compositions of a synergistic combination of a cardiac glycoside and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be a taxane are also provided. The compositions may also be used in a method for modulating Na+K+ATPase activity. In addition, a method for inhibiting the progression or development of breast cancer in vivo by administering either actein or an extract of black cohosh comprising triterpene glycosides and optionally at least one other chemoprotective agent is provided.
摘要翻译： 通过施用协同量的洋地黄毒苷和任意一种肌动蛋白或包含三萜糖苷的黑加索提取物，以及任选的另一种可能是紫杉醇的化学预防剂，提供了治疗，预防或改善乳腺癌的方法。 还提供了使用协同组合治疗或预防肿瘤的方法，以及强心苷和任意一种肌动蛋白或包含三萜糖苷的黑加索提取物的协同组合的组合物，以及任选的另一种可能是紫杉烷的化学预防剂。 组合物也可用于调节Na + K + ATP酶活性的方法。 此外，提供了通过施用包含三萜糖苷和任选的至少一种其它化学保护剂的肌动蛋白或黑加索提取物来抑制体内乳腺癌进展或发展的方法。
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公开(公告)号：US20120034217A1
公开(公告)日：2012-02-09
申请号：US13208962
申请日：2011-08-12
IPC分类号： A61K39/395 , A61K31/7048 , A61P35/02 , A61K31/58 , A61P35/00 , A61K33/24 , C07J71/00
CPC分类号： A61K45/06 , A61K31/704 , A61K36/71 , A61K2300/00
摘要： The present invention provides a composition for use in treating or preventing neoplasia, comprising an effective actein. The present invention also provides a composition for use in treating or preventing neoplasia, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh. The present invention further provides a combination of anti-neoplastic agents, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh and an effective anti-neoplastic amount of at least one additional chemopreventive or chemotherapeutic agent. Methods for treating and preventing neoplasia are also provided.
摘要翻译： 本发明提供了用于治疗或预防肿瘤形成的组合物，其包含有效的actein。 本发明还提供了用于治疗或预防瘤形成的组合物，其包含有效的抗肿瘤量的黑加索的乙酸乙酯萃取物。 本发明还提供抗肿瘤剂的组合，其包含有效的抗肿瘤量的黑色高原的乙酸乙酯提取物和有效抗肿瘤量的至少一种另外的化学预防或化学治疗剂。 还提供了治疗和预防肿瘤的方法。
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6.发明授权Methods and compositions for prevention and treatment of atherosclerosis and hyperlipidemia with non-steroidal anti-inflammatory drugs 失效用非甾体抗炎药预防和治疗动脉粥样硬化和高脂血症的方法和组合物公开(公告)号：US06201028B1
公开(公告)日：2001-03-13
申请号：US09208613
申请日：1998-12-08
IPC分类号： A01N4340
CPC分类号： A61K31/606 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/5415 , A61K31/616 , A61K45/06 , Y10S514/824
摘要： Methods and compositions for the prevention and/or treatment of cardiovascular diseases, the methods comprising administering to individuals in need thereof, an effective amount of a non-steroidal anti-inflammatory drug alone or in combination with other conventional therapies to induce apoptosis, reduce proliferation, induce quiescence, inhibit cell migration, or influence cell differentiation of the cells in the vascular wall and or/induce hypolipidemia.
摘要翻译： 用于预防和/或治疗心血管疾病的方法和组合物，所述方法包括向有需要的个体施用有效量的非甾体抗炎药单独或与其它常规治疗组合以诱导凋亡，减少增殖 ，诱导静止，抑制细胞迁移或影响细胞在血管壁中的分化和/或诱导低血脂症。
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公开(公告)号：US09486525B2
公开(公告)日：2016-11-08
申请号：US13208962
申请日：2011-08-12
IPC分类号： A61K36/00 , A61K45/06 , A61K31/704 , A61K36/71
CPC分类号： A61K45/06 , A61K31/704 , A61K36/71 , A61K2300/00
摘要： The present invention provides a composition for use in treating or preventing neoplasia, comprising an effective actein. The present invention also provides a composition for use in treating or preventing neoplasia, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh. The present invention further provides a combination of anti-neoplastic agents, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh and an effective anti-neoplastic amount of at least one additional chemopreventive or chemotherapeutic agent. Methods for treating and preventing neoplasia are also provided.
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公开(公告)号：US20090075919A1
公开(公告)日：2009-03-19
申请号：US12221478
申请日：2008-08-04
IPC分类号： A61K31/704 , C07H15/24 , A61P35/00
CPC分类号： A61K45/06 , A61K31/704 , A61K36/71 , A61K2300/00
摘要： The present invention provides a composition for use in treating or preventing neoplasia, comprising an effective actein. The present invention also provides a composition for use in treating or preventing neoplasia, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh. The present invention further provides a combination of anti-neoplastic agents, comprising an effective anti-neoplastic amount of an ethyl acetate extract of black cohosh and an effective anti-neoplastic amount of at least one additional chemopreventive or chemotherapeutic agent. Methods for treating and preventing neoplasia are also provided.
摘要翻译： 本发明提供了用于治疗或预防肿瘤形成的组合物，其包含有效的actein。 本发明还提供了用于治疗或预防瘤形成的组合物，其包含有效的抗肿瘤量的黑加索的乙酸乙酯萃取物。 本发明还提供抗肿瘤剂的组合，其包含有效的抗肿瘤量的黑色高原的乙酸乙酯提取物和有效抗肿瘤量的至少一种另外的化学预防或化学治疗剂。 还提供了治疗和预防肿瘤的方法。
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9.发明授权DNA oligomers for use in detection of campylobacter pylori and methods of using such DNA oligomers 失效用于检测幽门螺杆菌的DNA寡聚体和使用这种DNA寡聚体的方法
公开(公告)号：US5571674A
公开(公告)日：1996-11-05
申请号：US227475
申请日：1994-04-14
IPC分类号： C07K14/205 , C12Q1/68 , C12P19/34
CPC分类号： C07K14/205 , C12Q1/689
摘要： This invention provides a DNA oligomer having the sequence 5'GGACATAGGCTGATCTCTTAGC3' (SEQ ID NO: 1) and which is complementary to Campylobacter pylori 16S ribosomal RNA sequences, for use as a probe to detect Campylobacter pylori.This invention also provides DNA oligomers having the sequences 5'GCGCAATCAGCGTCAGGTAATG3' (SEQ ID NO: 2) and 5'GCTAAGAGATCAGCCTATGTCCC3' (SEQ ID NO: 3) and which are complementary to certain Campylobacter pylori 16S ribosomal RNA sequences, for use as polymerase chain reaction primers for the detection of Campylobacter pylori.This invention also provides a method for producing species-specific bacterial or protozoan DNA oligomers encoding 16S ribosomal RNA by means of the polymerase chain reaction for use as species-specific probes and PCR primers, and methods for detection and identification of bacteria and protozoa.Further, this invention provides a DNA oligomer having the sequence 5'ACGGGCGGTGTGTGC3' (SEQ ID NO: 4).
摘要翻译： 本发明提供具有序列5'GGACATAGGCTGATCTCTTAGC3'（SEQ ID NO：1）并与幽门螺杆菌16S核糖体RNA序列互补的DNA寡聚体，用作检测幽门螺杆菌的探针。 本发明还提供具有序列5'GCGCAATCAGCGTCAGGTAATG3'（SEQ ID NO：2）和5'GCTAAGAGATCAGCCTATGTCCC3'（SEQ ID NO：3）的DNA寡聚体，它们与某些幽门螺杆菌16S核糖体RNA序列互补，用作聚合酶链 用于检测幽门螺杆菌的反应引物。 本发明还提供了通过用作物种特异性探针和PCR引物的聚合酶链反应来生产编码16S核糖体RNA的物种特异性细菌或原生动物DNA寡聚体的方法，以及用于检测和鉴定细菌和原生动物的方法。 此外，本发明提供具有5'ACGGGGGGGTGTGTGC3'（SEQ ID NO：4）序列的DNA寡聚体。
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公开(公告)号：US20120208776A1
公开(公告)日：2012-08-16
申请号：US13440655
申请日：2012-04-05
申请人： Linda Saxe Einbond , Morando Soffritti , Kyle Louis Kolaja , Richard John Brennan , I. Bernard Weinstein , Joan Weinstein , Tamara Weinstein , Claudia Weinstein , Matthew Weinstein
发明人： Linda Saxe Einbond , Morando Soffritti , Kyle Louis Kolaja , Richard John Brennan , I. Bernard Weinstein , Joan Weinstein , Tamara Weinstein , Claudia Weinstein , Matthew Weinstein
IPC分类号： A61K31/7048 , C12N9/99 , A61P35/00
CPC分类号： A61K31/704 , A61K31/7048 , A61K36/71 , A61K45/06 , A61K2300/00
摘要： A method is provided for treating, preventing or ameliorating neoplasia in a subject. This method includes administering to the subject an amount of actein or an amount of an extract of black cohosh that contains a triterpene glycoside, which amount of the actein or black cohosh is effective to treat, prevent or ameliorate the neoplasia, in combination with an amount of a statin which is effective to treat, prevent, or ameliorate the neoplasia. Related methods for treating, preventing or ameliorating breast cancer, or liver cell neoplasia are also provided. In addition, methods for modulating a cholesterol biosynthesis pathway and a stress response pathway in a subject are provided. These methods include administering to a subject a composition comprising an anti-neoplastic synergistic amount of a statin and actein. Compositions for carrying out such methods are also provided.
摘要翻译： 提供一种用于治疗，预防或改善受试者中的瘤形成的方法。 该方法包括向受试者施用一定量的肌动蛋白或含有三萜糖苷的黑加索提取物的量，所述三萜糖苷的量与所述肌动蛋白或黑加索的量有效地用于治疗，预防或改善瘤形成， 的他汀类药物有效治疗，预防或改善肿瘤。 还提供了治疗，预防或改善乳腺癌或肝细胞瘤形成的相关方法。 此外，提供了调节受试者中胆固醇生物合成途径和应激反应途径的方法。 这些方法包括向受试者施用包含抗肿瘤协同量的他汀和actein的组合物。 还提供了用于实施这些方法的组合物。
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