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    Efficient biomolecule recycling method and system
    1.
    发明授权
    Efficient biomolecule recycling method and system 有权

    公开(公告)号：US09765396B2

    公开(公告)日：2017-09-19

    申请号：US15076962

    申请日：2016-03-22

    Applicant: Illumina, Inc.

    Inventor： Chanfeng Zhao

    IPC: C12Q1/68 ,  C08F2/00 ,  C08G85/00

    CPC classification number: C12Q1/6874 ,  C12Q2563/107 ,  C12Q2565/629 ,  C12Q2565/30

    Abstract: A technique is disclosed for recapturing and recycling biomolecule reagents. The technique may be applied in a range of settings, including biopolymer synthesis, sequencing, and so forth. Biomolecule reagents such as nucleotides and oligonucleotides used to process nucleic acids, which may be marked with fluorescent tags, carry blocking agents, and so forth, are introduced to samples in a sample container. After the desired reaction occurs with some of the biomolecule reagents, such as some of the nucleotides or oligonucleotides, the effluent stream is processed to recapture unreacted biomolecule reagents. These may be separated from other reaction components, and recycled into the same or a different sample container. The recaptured biomolecule reagents may be mixed with additional biomolecule reagents prior to reintroduction to the same or different samples.

    Independently removable nucleic acid sequencing system and method
    4.
    发明授权
    Independently removable nucleic acid sequencing system and method 有权
    独立拆除的核酸测序系统及方法

    公开(公告)号：US09121063B2

    公开(公告)日：2015-09-01

    申请号：US13653979

    申请日：2012-10-17

    Applicant: ILLUMINA, INC.

    Inventor： Robert C. Kain ,  David L. Heiner ,  Chanfeng Zhao ,  Kevin Gunderson

    IPC: G06F19/22 ,  C12Q1/68 ,  C12M1/34

    CPC classification number: C12Q1/6874 ,  C12Q1/686 ,  C12Q1/6869 ,  C12Q2565/501 ,  C12Q2537/143

    Abstract: A system for sequencing nucleic acids, that includes (a) a table having an arrangement of sites, including a site for receiving a first substrate, and a site for receiving a second substrate, the substrates each having an array for providing sequencing data for a plurality of different nucleic acids in parallel; (b) a plurality of stations configured to carry out manipulations in a sequencing procedure; and (c) a system control interface configured to direct relative movement between the table and the plurality of stations, and to direct different steps of the sequencing procedure to occur at the sites for receiving the different substrates, wherein the first substrate can be removed from the system independently of the second substrate such that the second substrate can be processed to obtain sequencing data independently of the first substrate.

    Abstract translation: 一种用于对核酸进行测序的系统，其包括（a）具有位置排列的表，包括用于接收第一底物的位点和用于接收第二底物的位点，所述基底各自具有阵列，用于提供用于 多个不同的核酸并行; （b）多个站，被配置为在排序过程中执行操作; 以及（c）系统控制接口，被配置为引导所述台与所述多个站之间的相对运动，并且引导所述排序程序的不同步骤在用于接收所述不同衬底的位置处发生，其中所述第一衬底可以从 所述系统独立于所述第二衬底，使得可以处理所述第二衬底以获得独立于所述第一衬底的测序数据。

    NUCLEIC ACID SEQUENCING SYSTEM
    5.
    发明申请
    NUCLEIC ACID SEQUENCING SYSTEM 有权

    公开(公告)号：US20250011864A1

    公开(公告)日：2025-01-09

    申请号：US18887904

    申请日：2024-09-17

    Applicant: ILLUMINA, INC.

    Inventor： Robert C. Kain ,  David L. Heiner ,  Chanfeng Zhao ,  Kevin Gunderson

    IPC: C12Q1/6874 ,  C12Q1/686 ,  C12Q1/6869

    Abstract: A system for sequencing nucleic acid comprising a plurality of stations and a system control. The system control configured to direct the first substrate to progress and retrogress between the first processing station and the imaging station, direct the second substrate to progress and retrogress between the second processing station and the imaging station, and direct a chemistry cycle of a first sequencing procedure to occur within one of the first processing station or the second processing station while an imaging cycle of a second sequencing procedure occurs within the imaging station.

    Compositions and methods for nucleotide sequencing
    6.
    发明授权
    Compositions and methods for nucleotide sequencing 有权
    核苷酸测序的组成和方法

    公开(公告)号：US08808988B2

    公开(公告)日：2014-08-19

    申请号：US13846401

    申请日：2013-03-18

    Applicant: Illumina, Inc.

    Inventor： Chanfeng Zhao ,  Igor Kozlov ,  Melissa Won

    IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/02 ,  C07G3/00

    CPC classification number: C12Q1/6869 ,  C07H19/04 ,  C12P19/34 ,  C12Q1/6823 ,  C12Q2525/117 ,  C12Q2525/186 ,  C12Q2563/107

    Abstract: The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and/or a blocking group.

    Abstract translation: 本发明提供了含有连接标记如染料的可切割连接子的核苷和核苷酸分子。 本发明还提供含有可拆卸或不可移除的封闭基团的核苷和核苷酸分子。 本发明另外提供了使用含有可裂解连接子和/或封闭基团的核苷和核苷酸分子的方法。

    NUCLEIC ACID SEQUENCING SYSTEM AND METHOD
    8.
    发明申请
    NUCLEIC ACID SEQUENCING SYSTEM AND METHOD 有权
    核酸序列测序系统及方法

    公开(公告)号：US20150072871A1

    公开(公告)日：2015-03-12

    申请号：US14539765

    申请日：2014-11-12

    Applicant: ILLUMINA, INC.

    Inventor： Robert C. Kain ,  David L. Heiner ,  Chanfeng Zhao ,  Kevin Gunderson

    IPC: C12Q1/68

    CPC classification number: C12Q1/6874 ,  C12Q1/686 ,  C12Q1/6869 ,  G06F19/20 ,  G06F19/22 ,  C12Q2565/501 ,  C12Q2537/143

    Abstract: A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.

    Abstract translation: 公开了以自动或半自动方式测序核酸的技术。 多个核酸位点的样品阵列在多个周期内进行处理以向要测序的材料添加核苷酸，检测添加到位点的核苷酸，以及去除阻断剂的添加核苷酸和用于鉴定最后添加的标签 核苷酸。 对系统的多个参数进行监控，以便在样品排序期间发生问题的诊断和纠正。 质量控制程序在排序过程中运行，以确定样品的质量和收集的数据的质量。

    INDEPENDENTLY REMOVABLE NUCLEIC ACID SEQUENCING SYSTEM AND METHOD
    9.
    发明申请
    INDEPENDENTLY REMOVABLE NUCLEIC ACID SEQUENCING SYSTEM AND METHOD 有权

    公开(公告)号：US20230076823A1

    公开(公告)日：2023-03-09

    申请号：US18050183

    申请日：2022-10-27

    Applicant: Illumina, Inc.

    Inventor： Robert C. Kain ,  David L. Heiner ,  Chanfeng Zhao ,  Kevin Gunderson

    IPC: C12Q1/6874 ,  C12Q1/686 ,  C12Q1/6869

    Abstract: A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.

    INDEPENDENTLY REMOVABLE NUCLEIC ACID SEQUENCING SYSTEM AND METHOD
    10.
    发明申请
    INDEPENDENTLY REMOVABLE NUCLEIC ACID SEQUENCING SYSTEM AND METHOD 审中-公开

    公开(公告)号：US20190085389A1

    公开(公告)日：2019-03-21

    申请号：US16105262

    申请日：2018-08-20

    Applicant: Illumina, Inc.

    Inventor： Robert C. Kain ,  David L. Heiner ,  Chanfeng Zhao ,  Kevin Gunderson

    IPC: C12Q1/6874 ,  C12Q1/6869 ,  C12Q1/686

    Abstract: A technique for sequencing nucleic acids in an automated or semi-automated manner is disclosed. Sample arrays of a multitude of nucleic acid sites are processed in multiple cycles to add nucleotides to the material to be sequenced, detect the nucleotides added to sites, and to de-block the added nucleotides of blocking agents and tags used to identify the last added nucleotide. Multiple parameters of the system are monitored to enable diagnosis and correction of problems as they occur during sequencing of the samples. Quality control routines are run during sequencing to determine quality of samples, and quality of the data collected.

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