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公开(公告)号：US20220267828A1
公开(公告)日：2022-08-25
申请号：US17548037
申请日：2021-12-10
Applicant: Industrial Technology Research Institute
Inventor： Min-Yuan CHOU , Kuang-Chi CHENG , Ming-Hua YANG , Jiun-Lin GUO
IPC: C12Q1/686 , C12Q1/6851 , C12Q1/6853 , C12Q1/6876
Abstract: A GAPDH nucleic acid detection kit includes a primer set for detecting GAPDH nucleic acid. The primer set for detecting GAPDH nucleic acid includes a forward inner primer for GAPDH nucleic acids, a forward outer primer for GAPDH nucleic acids, a backward inner primer for GAPDH nucleic acids and a backward outer primer for GAPDH nucleic acids. The primer set for detecting GAPDH nucleic acid is used in a loop-mediated isothermal amplification (LAMP).
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公开(公告)号：US20140178388A1
公开(公告)日：2014-06-26
申请号：US13761569
申请日：2013-02-07
Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventor： Min-Yuan CHOU , Chuan-Chuan HUANG , Hsiu-Chuan LI , Ya-Ping LAI
IPC: C07K16/28
CPC classification number: C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K2317/53 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/74 , C07K2317/94 , C07K2319/00 , C07K2319/70
Abstract: The present invention relates to a method for producing multivalent Fab fragments. In particular, the invention relates to a method for the generation of trimeric Fab fragments by co-expression of a gene construct comprising a heavy chain portion of a Fab fragment and an in-frame fused collagen-like peptide, and a gene construct consisting of a light chain portion of an IgG in mammalian cells. Uses of molecules generated using the method of the invention are also described.
Abstract translation: 本发明涉及多价Fab片段的制备方法。 特别地，本发明涉及通过共表达包含Fab片段的重链部分和框内融合的胶原样肽的基因构建体以及由以下构成的基因构建体组成的基因构建体来产生三聚体Fab片段的方法： 哺乳动物细胞中IgG的轻链部分。 还描述了使用本发明的方法产生的分子的用途。
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Patent Agency Ranking
公开(公告)号：US20210087266A1
公开(公告)日：2021-03-25
申请号：US16948563
申请日：2020-09-23
Applicant: Industrial Technology Research Institute
Inventor： Min-Yuan CHOU , Li-Tsen LIN , Chung-Yuan SUN , Ya-Ping LAI , Chin-Pen LAI , Ssu-Yuan WU , Mei-Wei LIN
Abstract: Antibodies and antigen-binding fragments that bind to TIGIT are disclosed. The disclosure further relates to methods and compositions for use in treating an immune-related disease (e.g., a cancer or an infection or infectious disease) by administering a composition disclosed herein.
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公开(公告)号：US20230416362A1
公开(公告)日：2023-12-28
申请号：US18318776
申请日：2023-05-17
Applicant: Industrial Technology Research Institute
Inventor： Min-Yuan CHOU , Li-Tsen LIN , Chung-Yuan SUN , Ya-Ping LAI , Chin-Pen LAI , Ssu-Yuan WU , Mei-Wei LIN
CPC classification number: C07K16/2803 , A61P35/00 , A61K45/06
Abstract: Antibodies and antigen-binding fragments that bind to TIGIT are disclosed. The disclosure further relates to methods and compositions for use in treating an immune-related disease (e.g., a cancer or an infection or infectious disease) by administering a composition disclosed herein.
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公开(公告)号：US20220228110A1
公开(公告)日：2022-07-21
申请号：US17564729
申请日：2021-12-29
Applicant: Industrial Technology Research Institute
Inventor： Yen-Ju LIN , Mei-Wei LIN , Min-Yuan CHOU
Abstract: A method for screening host cells expressing a target protein is provided. The method includes the following steps: providing an expression vector, the expression vector including a promoter, a gene encoding a target protein and an FTH1 gene; transfecting the host cells with the expression vector; culturing the host cells in a medium; and adding iron ions to the medium, and screening the surviving host cells to obtain the host cells expressing the target protein. An expression vector and a method for establishing a cell line stably expressing an exogenous recombinant gene are also provided.
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公开(公告)号：US20170320966A1
公开(公告)日：2017-11-09
申请号：US15589191
申请日：2017-05-08
Applicant: Industrial Technology Research Institute
Inventor： Chia-Yu FAN , Min-Yuan CHOU
CPC classification number: C07K16/46 , A61K39/0011 , A61K39/44 , A61K2039/5152 , C07K16/18 , C07K16/28 , C07K16/2896 , C07K16/462 , C07K19/00 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: A humanized monoclonal antibody against the CD34 surface antigen is provided in the present disclosure. The humanized monoclonal antibody includes a light chain variable region and a heavy chain variable region. In which, a nucleotide sequence encoding the amino acid sequence for the light chain variable region comprises a nucleotide sequence which encodes the amino acid sequence of SEQ ID No. 9 or an amino acid sequence with at least 80% sequence identity to the sequence of SEQ ID No. 9, and a nucleotide sequence encoding the amino acid sequence for the heavy chain variable region comprises a nucleotide sequence which encodes the amino acid sequence of SEQ ID No. 10 or an amino acid sequence with at least 80% sequence identity to the sequence of SEQ ID No. 10.
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公开(公告)号：US20130172533A1
公开(公告)日：2013-07-04
申请号：US13646530
申请日：2012-10-05
Applicant: Industrial Technology Research Institute
Inventor： Wei-Chun CHIU , Min-Yuan CHOU
IPC: C07K16/28 , C12N5/0789 , C07K17/00 , C12N5/071 , B82Y5/00
CPC classification number: C12N5/0647 , C07K16/2896 , C07K2317/24 , C07K2317/92
Abstract: A novel humanized antibody against the CD34 surface antigen on the human stem cells is provided. The humanized antibody contains a heavy chain variable region comprising an amino sequence as set forth in SEQ ID No. 1 and a light chain variable region comprising an amino sequence as set forth in SEQ ID No. 2. The disclosure also provides the applications of the disclosed humanized antibody.
Abstract translation: 提供了针对人干细胞上的CD34表面抗原的新型人源化抗体。 人源化抗体含有包含SEQ ID No.1所示氨基酸序列的重链可变区和包含SEQ ID No.2所示氨基序列的轻链可变区。本公开还提供了 公开了人源化抗体。
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