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公开(公告)号:US20250058042A1
公开(公告)日:2025-02-20
申请号:US18800698
申请日:2024-08-12
Applicant: INSULET CORPORATION
Inventor: Joon Bok LEE , Yibin ZHENG , William WHITELEY , Jason O’CONNOR
IPC: A61M5/142
Abstract: The exemplary embodiments may provide a correction factor (CF) for a user that is dynamically adjustable based on current glucose level. In some exemplary embodiments, the CF of the user is adjusted based on the current glucose level of the user. As the current glucose level of the user increases to be above a threshold, the CF may be adjusted to reflect a decrease in the insulin sensitivity of the user. This adjustment may cause the control system to increase the amount of insulin delivered to the user as the glucose level of the user exceeds the threshold. Similarly, the CF of the user may be adjusted based on the current target glucose level of the user or based on a combination of the current glucose level of the user and the current target glucose level of the user.
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公开(公告)号:US20250018114A1
公开(公告)日:2025-01-16
申请号:US18903653
申请日:2024-10-01
Applicant: Insulet Corporation
Inventor: Joon Bok LEE , Jason O’CONNOR , Yibin ZHENG , Ashutosh ZADE
IPC: A61M5/172 , A61B5/00 , A61B5/145 , A61K38/22 , A61K38/26 , A61K38/28 , A61M5/14 , A61M5/142 , G16H20/17 , G16H40/67
Abstract: Disclosed herein are systems and methods for the delivery of a co-formulation of insulin and a second drug, such as GLP-1, using an automated insulin delivery system. In a first embodiment, a dose of insulin is calculated by a medication delivery algorithm and a reduction factor is applied to account for the effect of second drug on the user's daily insulin requirement. In a second embodiment of the invention, a total amount of the second drug administered to the user during the past 24 hours is used to modify the correction factor and the insulin-to-carbohydrate ratio used by the medication delivery algorithm to cause a reduction in the insulin delivered to the user to account for the effect of the administration of the second drug portion of the co-formulation.
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3.
公开(公告)号:US20240299660A1
公开(公告)日:2024-09-12
申请号:US18667224
申请日:2024-05-17
Applicant: INSULET CORPORATION
Inventor: Joon Bok LEE , Ashutosh ZADE , Jason O'CONNOR , Trang LY , Yibin ZHENG , Connor GULLIFER , Kyle GROVER
CPC classification number: A61M5/1723 , G16H20/17 , A61M2202/07 , A61M2205/18 , A61M2205/3569 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2230/201
Abstract: The exemplary embodiments attempt to identify impending hypoglycemia and/or hyperglycemia and take measures to prevent the hypoglycemia or hyperglycemia. Exemplary embodiments may provide a drug delivery system for delivering insulin and glucagon as needed by a user of the drug delivery system. The drug delivery system may deploy a control system that controls the automated delivery of insulin and glucagon to a patient by the drug delivery system. The control system seeks among other goals to avoid the user experiencing hypoglycemia or hyperglycemia. The control system may employ a clinical decision support algorithm as is described below to control delivery of insulin and glucagon to reduce the risk of hypoglycemia or hyperglycemia and to provide alerts to the user when needed. The control system assesses whether the drug delivery system can respond enough to avoid hypoglycemia or hyperglycemia and generates alerts when manual action is needed to avoid hypoglycemia or hyperglycemia.
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4.
公开(公告)号:US20240157055A1
公开(公告)日:2024-05-16
申请号:US18508361
申请日:2023-11-14
Applicant: INSULET CORPORATION
Inventor: Joon Bok LEE , Yibin ZHENG , Jason O'CONNOR , Ashutosh ZADE
CPC classification number: A61M5/1723 , G16H40/67 , G16H50/20 , G16H50/30 , A61M2005/14208
Abstract: A drug delivery system including a memory storing programming code operable to enable delivery of insulin and a processor operable to execute the programming code. When executed, the programming code causes the processor to: calculate a first aggregate insulin-on-board amount for a user based on a plurality of individual insulin-on-board estimates made over a first period of time, determine that the first aggregate insulin-on-board amount is greater than a maximum depot formation threshold amount, determine a first residual amount of insulin remaining in the first aggregate insulin-on-board amount, increase a subsequent calculation of an individual insulin-on-board estimate based on the first residual amount of insulin, and utilize the subsequent calculation of the individual insulin-on-board estimate in a calculation of a second aggregate insulin-on-board amount over a second period of time.
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5.
公开(公告)号:US20240123141A1
公开(公告)日:2024-04-18
申请号:US18482414
申请日:2023-10-06
Applicant: INSULET CORPORATION
Inventor: Joon Bok LEE , James CAUSEY , John D’ARCO , Jason O'CONNOR
CPC classification number: A61M5/14244 , A61M5/1723 , G16H20/17 , G16H50/50 , A61M2005/1401 , A61M2005/14292 , A61M2005/14296
Abstract: Disclosed herein is a system and method for calculating an expected peak blood glucose level of user during a post-prandial period, based on a quantity of carbohydrates to be ingested. The user's expected peak blood glucose levels for slow, medium and fast acting carbohydrates are calculated. The results are presented to the user to allow the user to make an informed decision regarding the type of meal to be ingested.
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公开(公告)号:US20240075208A1
公开(公告)日:2024-03-07
申请号:US18240423
申请日:2023-08-31
Applicant: INSULET CORPORATION
Inventor: Joon Bok LEE , James CAUSEY , John D’ARCO , Jason O'CONNOR
CPC classification number: A61M5/1723 , A61M5/1413 , A61M5/14244 , G05B13/048 , G16H40/63 , G16H50/50 , A61M2005/14208 , A61M2005/14252 , A61M2005/14292 , A61M2005/1726 , A61M2202/0007 , A61M2202/04 , A61M2205/18 , A61M2205/3303 , A61M2205/3327 , A61M2205/3389 , A61M2205/3561 , A61M2205/3576 , A61M2205/52 , A61M2230/201
Abstract: Disclosed herein is a system and method implementing a software-based method for detecting or confirming the detection of occlusions in the fluid path of an automatic drug delivery system. The invention uses real time glucose readings from a continuous glucose monitor in collaboration with past insulin delivery history and user indications of ingestion of carbohydrates, to determine cases where the user's glucose concentration is not being sufficiently impacted by the expected insulin delivery, which may indicate a significant pump site issue.
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公开(公告)号:US20230310742A1
公开(公告)日:2023-10-05
申请号:US18190572
申请日:2023-03-27
Applicant: INSULET CORPORATION
Inventor: Joon Bok LEE , Eric BENJAMIN , Jason O'CONNOR , Yibin ZHENG , Ashutosh ZADE
CPC classification number: A61M5/1723 , A61M5/14244 , A61M5/16877 , A61M2205/3576 , A61M2205/52 , A61M2202/0486
Abstract: Disclosed are techniques, processes, systems, and programming code that enables users of automatic drug delivery devices to initiate the automatic drug delivery device for an initial use phase as well as implement changes that control the adjustment of target setpoints by a medication delivery algorithm used in the control of the automatic drug delivery device. During the initial use phase, the automatic drug delivery device may be based on the user's glucose control outcome without performing time consuming and frequent settings of sensor values as well as allowing users to remain substantially within range of any target setpoints. In addition, the disclosed techniques, processes, systems, and programming code enable users to have initial dosage settings automatically set without having to input what were previously considered fundamental inputs.
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公开(公告)号:US20230233765A1
公开(公告)日:2023-07-27
申请号:US18190678
申请日:2023-03-27
Applicant: INSULET CORPORATION
Inventor: Jason O’CONNOR , Joon Bok LEE , Trang LY , Todd VIENNEAU , Yibin ZHENG , Ashutosh ZADE
CPC classification number: A61M5/1723 , A61K38/28 , A61M5/14248 , A61M2005/14252 , A61M2205/18 , A61M2205/52 , A61M2205/502 , A61M2205/3553 , A61M2205/3584 , A61M2230/63 , A61M2230/201
Abstract: A wearable drug delivery device, techniques, and computer-readable media that provide an application that implements a diabetes treatment plan for a user are described. The drug delivery device may include a controller operable to direct operation of the wearable drug delivery device. The controller may provide a selectable activity mode of operation for the user. Operation of the drug delivery device in the activity mode of operation may reduce a likelihood of hypoglycemia during times of increased insulin sensitivity for the user and may reduce a likelihood of hyperglycemia during times of increased insulin requirements for the user. The activity mode of operation may be manually activated by the user or may be activated automatically by the controller. The controller may automatically activate the activity mode of operation based on a detected activity level of the user and/or a detected location of the user.
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公开(公告)号:US20220379029A1
公开(公告)日:2022-12-01
申请号:US17824494
申请日:2022-05-25
Applicant: Insulet Corporation
Inventor: Ashutosh ZADE , Joon Bok LEE , Yibin ZHENG
Abstract: Provided is a wearable medical device that includes a processor or logic circuitry. The wearable medical device may include a memory storing instructions that, when executed by the processor or logic circuitry, configure the wearable medical device to determine, by the processor or the logic circuitry, that an event affecting a blood glucose measurement value trend of a user has occurred. Based on the occurrence of the event, the processor or the logic circuitry may select a mode of operation of the analyte sensor, and generate a signal indicating the selected mode of operation. The mode of operation may correspond to a sampling frequency of a physical attribute or physiological condition of a user of the wearable medical device.
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10.
公开(公告)号:US20220347386A1
公开(公告)日:2022-11-03
申请号:US17730839
申请日:2022-04-27
Applicant: Insulet Corporation
Inventor: Ashutosh ZADE , Joon Bok LEE , Yibin ZHENG
Abstract: Disclosed are processes and techniques implementable by a drug delivery system to maintain optimal drug delivery for a patient according to a treatment plan. The disclosed techniques enable a new drug delivery device that is exchanged for a previous drug delivery device to operate using analyte-based drug delivery control immediately during initialization instead of having to wait for a warm-up period. For example, a drug delivery device may include a processor and a memory storing instructions that, when executed by the processor, operate the drug delivery device to receive a present analyte measurement value from an analyte sensor during an initialization of the drug delivery device, receive backfill values measured by the analyte sensor prior to the initialization, calculate a dosage of a drug using the present analyte measurement value and the backfill values, and deliver the dosage of the drug. Other embodiments are described.
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