公开(公告)号：US10203297B2

公开(公告)日：2019-02-12

申请号：US14879948

申请日：2015-10-09

Applicant: INTEL CORPORATION

Inventor： Jonathan S. Daniels ,  Oguz H. Elibol ,  Grace M. Credo ,  Xing Su

IPC: G01N27/327 ,  C12Q1/68 ,  G01R27/26 ,  G01N27/22 ,  G01K7/34 ,  G06K7/08 ,  G01D5/24 ,  G01L1/14 ,  B82Y30/00

Abstract: Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.

公开(公告)号：USD839108S1

公开(公告)日：2019-01-29

申请号：US29605988

申请日：2017-05-31

Applicant: Intel Corporation

Designer： Narayan Sundararajan ,  Grace M. Credo ,  Khurshaduzzaman Razib ,  Nuzhat Binte. Arif ,  Fahim Al. Hasnaeen ,  Kazi I. Huque

公开(公告)号：US09222908B2

公开(公告)日：2015-12-29

申请号：US13839564

申请日：2013-03-15

Applicant: Intel Corporation

Inventor： Jonathan S. Daniels ,  Oguz H. Elibol ,  Grace M. Credo ,  Xing Su

IPC: G01N27/30 ,  B82Y30/00 ,  G01N27/327

CPC classification number: G01N27/30 ,  B82Y30/00 ,  G01N27/3277 ,  Y10S977/734 ,  Y10S977/742

Abstract: Described herein is a device comprising: a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a fluid and having a capacitance; first circuitry configured to controllably set the plurality of first reaction electrode to a predetermined voltage and allow the capacitance of the plurality of first reaction electrode to charge or discharge through the fluid; and second circuitry configured to measure a rate of charging or discharging of the capacitance of the plurality of first reaction electrodes. Also described herein is a method of using this device to sequence DNA.

Abstract translation: 本文描述的是一种装置，包括：多个以阵列排列的第一反应电极，多个第一反应电极构造成暴露于流体并具有电容; 第一电路，被配置为可控地将所述多个第一反应电极设置为预定电压，并允许所述多个第一反应电极的电容通过所述流体进行充电或放电; 以及第二电路，被配置为测量所述多个第一反应电极的电容的充电或放电速率。 本文还描述了使用该装置来对DNA进行序列化的方法。

公开(公告)号：US20160282265A1

公开(公告)日：2016-09-29

申请号：US14669514

申请日：2015-03-26

Applicant: Intel Corporation

Inventor： Xing Su ,  Kadhair Al-Hemyari ,  Kai Wu ,  Grace M. Credo ,  Haisheng Rong ,  Jacob Sendowski

IPC: G01N21/41

CPC classification number: G01N21/7746 ,  G01N21/39 ,  G01N21/553 ,  G01N2021/773 ,  G01N2021/7776

Abstract: An embodiment includes a sensor comprising a substrate die; a photonic ring resonator (RR) on the substrate die; a polymer, on the RR, having an affinity to a chemical analyte; a photonic waveguide on the substrate die and coupled to the RR; a laser, on the substrate die and coupled to the waveguide, to emit optical energy that operates with the RR at a resonance wavelength; and a photodetector, on the substrate die and coupled to the waveguide, to detect a change in refractive index (RI) of the RR operating with the optical energy in response to the polymer coupling to the analyte. Other embodiments are described herein.

Abstract translation: 一个实施例包括一个包括一个基片的传感器; 在衬底裸片上的光子环谐振器（RR）; RR上的聚合物对化学分析物具有亲和性; 衬底上的光子波导管并耦合到RR; 激光器，在基板裸片上并且耦合到波导，以发射与RR在谐振波长下工作的光能; 以及光电检测器，其在所述基板裸片上并耦合到所述波导，以检测响应于与所述分析物的所述聚合物耦合而用所述光能操作的所述RR的折射率（RI）的变化。 本文描述了其它实施例。