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1.发明授权Elisa kit for the rapid determination of N-acetyltransferase (NAT2) phenotypes 失效Elisa试剂盒用于快速测定N-乙酰转移酶（NAT2）表型
公开(公告)号：US5830672A
公开(公告)日：1998-11-03
申请号：US594934
申请日：1996-01-31
IPC分类号： C12Q1/48 , G01N33/53 , G01N33/574 , G01N33/573
CPC分类号： C12Q1/48 , G01N33/5308 , G01N33/574 , Y10S436/813
摘要： The invention relates to an enzyme linked immunosorbent assay (ELISA) kit for the rapid determination of N-acetyltransferase (NAT2) phenotype which can be used on a routine basis in a clinical laboratory. The ELISA kit allows physicians to: a) individualize therapy of drugs such as amrinone, procainamide, amonafide, dapsone, isoniazid, trimethoprim-sulphamethoxazole (TMP-SMX) and b) to predict susceptibility to carcinogen induced diseases such as bladder and colon rectal cancers.
摘要翻译： 本发明涉及用于快速测定N-乙酰转移酶（NAT2）表型的酶联免疫吸附测定（ELISA）试剂盒，其可以在临床实验室中常规使用。 ELISA试剂盒允许医师：a）个体化药物的治疗，如氨酚，普鲁卡因胺，阿莫奈酯，氨苯砜，异烟肼，甲氧苄啶 - 磺胺甲恶唑（TMP-SMX）和b）预测对致癌物质诱发的疾病如膀胱和结肠直肠癌的易感性 。
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2.发明申请PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE 审中-公开（R，R） - 芬醇和（R，R）-OR（R，S） - 芬太醇类似物的制备及其在治疗心绞痛失败中的应用公开(公告)号：US20100168245A1
公开(公告)日：2010-07-01
申请号：US12376945
申请日：2007-08-10
申请人： Irving W. Wainer , Weizhong Zhu , Khalid Chakir , Rui Ping Xiao , Darrell R. Abernethy , Farideh M. Beigi
发明人： Irving W. Wainer , Weizhong Zhu , Khalid Chakir , Rui Ping Xiao , Darrell R. Abernethy , Farideh M. Beigi
IPC分类号： A61K31/135 , C07C215/60 , A61P9/00 , A61P9/04 , A61P11/06
CPC分类号： C07C215/60
摘要： This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
摘要翻译： 本公开内容涉及在结合和β-肾上腺素能受体上高度有效的（R，R） - 和（R，S） - 非诺他醇类似物的发现。 提供了这些类似物的示例性化学结构。 还提供了包括所公开的（R，R） - 非勒醇和非诺特罗类似物的药物组合物，以及使用这些化合物和组合物治疗心脏病症如充血性心力衰竭和肺部疾病如哮喘或慢性阻塞性肺疾病的方法。
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公开(公告)号：US5807926A
公开(公告)日：1998-09-15
申请号：US729489
申请日：1996-10-11
CPC分类号： C12N9/0006 , C12N11/02 , C12P1/00 , C12P17/06 , C12P41/002
摘要： An oxido-reducto synthesis is carried out in a liquid medium with enzymatic transformation of a substrate with an oxido-reducto cofactor dependent enzyme in the presence of a cofactor for the transformation; the enzyme is immobilized by a support which is stationarily disposed in a flow path along which a liquid medium containing the substrate flows in contact with the support.
摘要翻译： 氧化还原合成在液体培养基中进行，在存在用于转化的辅因子的情况下，用氧化还原辅因子依赖性酶对底物进行酶转化; 该酶通过固定地设置在包含衬底的液体介质与载体接触的流动路径中的载体固定。
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4.发明授权Preparation of (R,R)-fenoterol and (R,R)-or (R,S)-fenoterol analogues and their use in treating congestive heart failure 有权（R，R） - 非诺他醇和（R，R） - 或（R，S） - 非诺他醇类似物的制备及其在治疗充血性心力衰竭中的应用公开(公告)号：US08703826B2
公开(公告)日：2014-04-22
申请号：US13333866
申请日：2011-12-21
申请人： Irving W. Wainer , Weizhong Zhu , Khalid Chakir , Rui Ping Xiao , Darrell R. Abernethy , Farideh M. Beigi
发明人： Irving W. Wainer , Weizhong Zhu , Khalid Chakir , Rui Ping Xiao , Darrell R. Abernethy , Farideh M. Beigi
IPC分类号： A61K31/135
CPC分类号： C07C215/60
摘要： This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
摘要翻译： 本公开内容涉及在结合和β-肾上腺素能受体上高度有效的（R，R） - 和（R，S） - 非诺他醇类似物的发现。 提供了这些类似物的示例性化学结构。 还提供了包括所公开的（R，R） - 非勒醇和非诺特罗类似物的药物组合物，以及使用这些化合物和组合物治疗心脏病症如充血性心力衰竭和肺部疾病如哮喘或慢性阻塞性肺疾病的方法。
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5.发明申请THE USE OF FENOTEROL AND FENOTEROL ANALOGUES IN THE TREATMENT OF GLIOBLASTOMAS AND ASTROCYTOMAS 有权芬太尼和芬太尔类似物在治疗青光眼和耳鼻喉科中的应用公开(公告)号：US20130005799A1
公开(公告)日：2013-01-03
申请号：US13583206
申请日：2011-03-10
IPC分类号： A61K31/137 , A61K31/351 , A61K31/166 , A61P35/00 , A61K31/175
CPC分类号： A61K31/137 , A61K45/06 , A61K2300/00
摘要： This disclosure concerns the discovery of the use of fenoterol and (R,R)- and (R,S)-fenoterol analogues for the treatment of a tumor expressing a β2-adrenergic receptor, such as a primary brain tumor, including a glioblastoma or astrocytoma expressing a β2-adrenergic receptor. In one example, the method includes administering to a subject a therapeutically effective amount of fenoterol, a specific fenoterol analogue or a combination thereof to reduce one or more symptoms associated with the tumor, thereby treating the tumor in the subject.
摘要翻译： 本公开涉及发现使用非诺特罗和（R，R） - 和（R，S） - 非诺他醇类似物用于治疗表达2-肾上腺素能受体的肿瘤，例如原发性脑肿瘤，包括 表达2-肾上腺素能受体的成胶质细胞瘤或星形细胞瘤。 在一个实例中，该方法包括向受试者施用治疗有效量的非诺特罗，特异性非尼诺类似物或其组合以减少与肿瘤相关的一种或多种症状，由此治疗受试者的肿瘤。
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6.发明申请PREPARATION OF (R,R)-FENOTEROL AND (R,R)-OR (R,S)-FENOTEROL ANALOGUES AND THEIR USE IN TREATING CONGESTIVE HEART FAILURE 有权（R，R） - 芬醇和（R，R）-OR（R，S） - 芬太醇类似物的制备及其在治疗心绞痛失败中的应用公开(公告)号：US20120157543A1
公开(公告)日：2012-06-21
申请号：US13333866
申请日：2011-12-21
申请人： Irving W. Wainer , Weizhong Zhu , Khalid Chakir , Rui Ping Xiao , Darrell R. Abernethy , Farideh M. Beigi
发明人： Irving W. Wainer , Weizhong Zhu , Khalid Chakir , Rui Ping Xiao , Darrell R. Abernethy , Farideh M. Beigi
IPC分类号： A61K31/137 , A61P11/06 , A61P9/00 , A61P9/04 , C07C215/60 , A61P11/00
CPC分类号： C07C215/60
摘要： This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
摘要翻译： 本公开内容涉及在结合和β-肾上腺素能受体上高度有效的（R，R） - 和（R，S） - 非诺他醇类似物的发现。 提供了这些类似物的示例性化学结构。 还提供了包括所公开的（R，R） - 非勒醇和非诺特罗类似物的药物组合物，以及使用这些化合物和组合物治疗心脏病症如充血性心力衰竭和肺部疾病如哮喘或慢性阻塞性肺疾病的方法。
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公开(公告)号：US20230165811A1
公开(公告)日：2023-06-01
申请号：US17922647
申请日：2021-05-04
申请人： Irving W. Wainer
发明人： Irving W. Wainer
IPC分类号： A61K31/137 , A61K45/06
CPC分类号： A61K31/137 , A61K45/06
摘要： A method for treating the symptoms of viral infections with fenoterol and/or fenoterol analogues.
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8.发明授权Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas 有权非诺特罗和非诺醇类似物在胶质母细胞瘤和星形细胞瘤的治疗中的应用公开(公告)号：US09492405B2
公开(公告)日：2016-11-15
申请号：US13583206
申请日：2011-03-10
IPC分类号： A61K31/135 , A01N33/02 , A61K31/137 , A61K45/06
CPC分类号： A61K31/137 , A61K45/06 , A61K2300/00
摘要： This disclosure concerns the discovery of the use of fenoterol and (R,R)- and (R,S)-fenoterol analogs for the treatment of a tumor expressing a β2-adrenergic receptor, such as a primary brain tumor, including a glioblastoma or astrocytoma expressing a β2-adrenergic receptor. In one example, the method includes administering to a subject a therapeutically effective amount of fenoterol, a specific fenoterol analog or a combination thereof to reduce one or more symptoms associated with the tumor, thereby treating the tumor in the subject.
摘要翻译： 本公开涉及发现使用fenoterol和（R，R） - 和（R，S） - 非那他醇类似物来治疗表达β2-肾上腺素能受体的肿瘤，例如原发性脑肿瘤，包括成胶质细胞瘤或 表达β2-肾上腺素能受体的星形细胞瘤。 在一个实例中，该方法包括向受试者施用治疗有效量的非诺特罗，特异性非诺特罗类似物或其组合以减少与肿瘤相关的一种或多种症状，由此治疗受试者的肿瘤。
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9.发明授权Computer-based model for identification and characterization of non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors 失效基于计算机的模型，用于鉴定和表征烟碱乙酰胆碱受体和相关配体门控离子通道受体的非竞争性抑制剂公开(公告)号：US07749984B2
公开(公告)日：2010-07-06
申请号：US10820809
申请日：2004-04-09
IPC分类号： A61K314/85 , C07C69/88
摘要： A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.
摘要翻译： 本发明提供了一种保存配体门控离子通道受体分子模型数据和/或用于建模所述受体的计算机系统的计算机可读介质。 该分子模型可用于设计具有作为离子通道的非竞争性抑制剂的活性的新型化合物。 本发明的优选实施方案涉及烟碱乙酰胆碱受体。 还公开了具有作为配体门控离子通道受体的非竞争性抑制剂的活性的化合物以及用于抑制受体和治疗由受体功能介导的疾病或病症的方法。
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