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公开(公告)号：US20160229905A1
公开(公告)日：2016-08-11
申请号：US15023165
申请日：2014-09-18
Applicant: JAMES COOK UNIVERSITY
Inventor： Alex Loukas , Andrew Leech , Darren Pickering
Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C—S—C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.
Abstract translation: 改良的Ac-TMP-2蛋白缺乏通常存在于全长或野生型Ac-TMP-2蛋白质中的一个或多个酸性C末端氨基酸，并且也可能缺少一个或多个N-末端氨基 酸，同时保留N-末端或其附近的氨基酸序列C-S-C。 修饰的Ac-TMP-2蛋白可用于减少或减轻受试者的炎症的方法和组合物。 炎症可能与疾病相关，是消化道疾病，如慢性胃炎或炎症性肠病如克罗恩病或溃疡性结肠炎，或呼吸系统疾病，如哮喘，肺气肿，慢性支气管炎和慢性疾病 阻塞性肺疾病。
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公开(公告)号：US11976108B2
公开(公告)日：2024-05-07
申请号：US17071563
申请日：2020-10-15
Applicant: James Cook University
Inventor： Alex Loukas , Andrew Leech , Darren Pickering
IPC: C07K14/81 , A61K38/00 , A61K38/57 , A61K45/06 , C07K14/435
CPC classification number: C07K14/81 , A61K38/57 , A61K45/06 , C07K14/4354 , C07K14/8146 , A61K38/00
Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C-S-C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.
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公开(公告)号：US20210061886A1
公开(公告)日：2021-03-04
申请号：US17071563
申请日：2020-10-15
Applicant: James Cook University
Inventor： Alex Loukas , Andrew Leech , Darren Pickering
IPC: C07K14/81 , A61K45/06 , C07K14/435 , A61K38/57
Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C-S-C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.
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公开(公告)号：US20160235813A1
公开(公告)日：2016-08-18
申请号：US15023108
申请日：2014-09-18
Applicant: JAMES COOK UNIVERSITY
Inventor： Cinzia Cantacessi , Alex Loukas
CPC classification number: A61K38/1767 , A61K38/1709 , A61K38/57 , A61K45/06
Abstract: A method and composition for reducing or alleviating inflammation in a subject is provided, including administering to the subject a therapeutically effective amount; of one or more isolated proteins respectively comprising an amino acid sequence set forth in SEQ ID NOS:1-31, or a biologically active fragment or variant thereof or combinations of these to thereby reduce or alleviate inflammation. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.
Abstract translation: 提供了用于减少或减轻受试者的炎症的方法和组合物，包括向受试者施用治疗有效量; 分别包含SEQ ID NO：1-31所示的氨基酸序列的一个或多个分离的蛋白质，或其生物活性片段或变体或它们的组合，从而减少或减轻炎症。 炎症可能与疾病相关，是消化道疾病，如慢性胃炎或炎症性肠病如克罗恩病或溃疡性结肠炎，或呼吸系统疾病，如哮喘，肺气肿，慢性支气管炎和慢性疾病 阻塞性肺疾病。
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Patent Agency Ranking
公开(公告)号：US20150037366A1
公开(公告)日：2015-02-05
申请号：US14384681
申请日：2013-03-13
Applicant: JAMES COOK UNIVERSITY
Inventor： Alex Loukas , Severine Navarro
IPC: C07K14/435 , A61K39/00 , A61K45/06
CPC classification number: C07K14/4354 , A61K38/57 , A61K39/0003 , A61K45/06
Abstract: A method for reducing or alleviating inflammation in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby reduce or alleviate inflammation in the subject. A method for preventing or treating asthma or inflammatory bowel disease in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby prevent or treat asthma or inflammatory bowel disease in the subject. The subject may be a mammal, inclusive of humans.
Abstract translation: 用于减轻或减轻受试者炎症的方法包括向受试者施用治疗有效量的：（a）Ac-TMP-1或Ac-TMP-1的生物活性片段或变体; （b）Ac-TMP-2或Ac-TMP-2的生物活性片段或变体; 或（c）（a）和（b）的组合，从而减少或缓解受试者的炎症。 用于预防或治疗受试者哮喘或炎症性肠病的方法包括向受试者施用治疗有效量的：（a）Ac-TMP-1或Ac-TMP-1的生物活性片段或变体; （b）Ac-TMP-2或Ac-TMP-2的生物活性片段或变体; 或（c）（a）和（b）的组合，从而预防或治疗受试者的哮喘或炎症性肠病。 受试者可以是哺乳动物，包括人类。
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公开(公告)号：US20240400649A1
公开(公告)日：2024-12-05
申请号：US18414112
申请日：2024-01-16
Applicant: James Cook University
Inventor： Alex Loukas , Andrew Leech , Darren Pickering
IPC: C07K14/81 , A61K38/00 , A61K38/57 , A61K45/06 , C07K14/435
Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C-S-C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.
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公开(公告)号：US10822395B2
公开(公告)日：2020-11-03
申请号：US15023165
申请日：2014-09-18
Applicant: James Cook University
Inventor： Alex Loukas , Andrew Leech , Darren Pickering
Abstract: A modified Ac-TMP-2 protein lacks one or a plurality of acidic C-terminal amino acids normally present in a full-length or wild-type Ac-TMP-2 protein and may also lack one or a plurality of N-terminal amino acids while retaining the amino acid sequence C—S—C at or near the N-terminus. The modified Ac-TMP-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as Crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease.
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公开(公告)号：US20190194279A1
公开(公告)日：2019-06-27
申请号：US16329800
申请日：2017-09-04
Applicant: James Cook University
Inventor： Alex Loukas , Michael Smout , Norelle Daly
IPC: C07K14/475 , A61P17/02
CPC classification number: C07K14/475 , A61K38/00 , A61P17/02 , A61P43/00
Abstract: Peptides derived from the N-terminal region of granulin have activity in promoting cell proliferation, migration and/or wound healing. Furthermore, an additional disulphide bond may be engineered into such peptides to improve or otherwise modify the folding of the peptide. The peptides may also be modified such as at proline residues improve the ability of the peptide to promote cell proliferation.
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公开(公告)号：US09637527B2
公开(公告)日：2017-05-02
申请号：US14384681
申请日：2013-03-13
Applicant: JAMES COOK UNIVERSITY
Inventor： Alex Loukas , Severine Navarro
IPC: C07K14/435 , A61K38/57 , A61K39/00 , A61K45/06
CPC classification number: C07K14/4354 , A61K38/57 , A61K39/0003 , A61K45/06
Abstract: A method for reducing or alleviating inflammation in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby reduce or alleviate inflammation in the subject. A method for preventing or treating asthma or inflammatory bowel disease in a subject includes administering to the subject a therapeutically effective amount of: (a) Ac-TMP-1 or a biologically active fragment or variant of Ac-TMP-1; (b) Ac-TMP-2 or a biologically active fragment or variant of Ac-TMP-2; or (c) a combination of (a) and (b), to thereby prevent or treat asthma or inflammatory bowel disease in the subject. The subject may be a mammal, inclusive of humans.
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