公开(公告)号：US6015701A

公开(公告)日：2000-01-18

申请号：US276968

申请日：1994-07-19

申请人： James Michael Pierce ,  Mohamed G. Shoreibah ,  Beverly Adler ,  Nevis Lee Fregien

发明人： James Michael Pierce ,  Mohamed G. Shoreibah ,  Beverly Adler ,  Nevis Lee Fregien

IPC分类号： A61K39/395 ,  C07K7/06 ,  C07K7/08 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N15/00 ,  C12N15/54 ,  C12R1/19 ,  C12R1/91 ,  G01N33/53 ,  C12N15/74 ,  C12N15/85

CPC分类号： C12N9/1051

摘要： The present invention provides substantially purified UDP-N-acetylglucosamine: .alpha.-6-D-mannoside .beta.-1,6-N-acetylglucosaminyl transferase (GlcNAc T-V; EC 2.4.1.155) proteins and antibodies which specifically bind GlcNAc T-V. The present invention also provides polynucleotide sequences and oligonucleotide probes capable of specifically hybridizing to nucleic acid sequences which encode GlcNAc T-V, and cDNA and genomic clones encoding GlcNAc T-V, as well as nucleotide sequences encoding GlcNAc T-V, as specifically exemplified by GlcNAc T-V coding sequences from rat, hamster, mouse and human.

摘要翻译： 本发明提供基本上纯化的UDP-N-乙酰葡糖胺：α-6-D-甘露糖苷β-1,6-N-乙酰氨基葡糖酰转移酶（GlcNAc T-V; EC 2.4.1.155）蛋白质和特异性结合GlcNAc T-V的抗体。 本发明还提供了能够与编码GlcNAc TV的核酸序列以及编码GlcNAc TV的cDNA和基因组克隆以及编码GlcNAc TV的核苷酸序列特异性杂交的多核苷酸序列和寡核苷酸探针，如GlcNAc TV编码序列 大鼠，仓鼠，小鼠和人类。

公开(公告)号：US5602003A

公开(公告)日：1997-02-11

申请号：US16863

申请日：1993-02-10

申请人： J. Michael Pierce ,  Mohamed G. Shoreibah ,  Beverly S. Adler ,  Nevis L. Fregien

发明人： J. Michael Pierce ,  Mohamed G. Shoreibah ,  Beverly S. Adler ,  Nevis L. Fregien

IPC分类号： A61K39/395 ,  C07K7/06 ,  C07K7/08 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N15/00 ,  C12N15/54 ,  C12R1/19 ,  C12R1/91 ,  G01N33/53 ,  C07H21/04

CPC分类号： C12N9/1051

摘要： The present invention provides a substantially purified UDP-N-acetylglucosamine:.alpha.-6-D-mannoside .beta.-1,6-N-acetylglucosaminyltransferase (GlcNAc T-V; EC 2.4.1.155) and antibodies which specifically bind GlcNAc T-V. The present invention also provides polynucleotide sequences and oligonucleotide probes capable of specifically hybridizing to nucleic acid sequences which encode GlcNAc T-V, and cDNA and genomic clones encoding GlcNAc T-V, as well as nucleotide sequences encoding GlcNAc T-V, as specifically exemplified by a GlcNAc T-V coding sequence from rat.

摘要翻译： 本发明提供基本上纯化的UDP-N-乙酰氨基葡萄糖：α-6-D-甘露糖苷β-1,6-N-乙酰葡糖胺基转移酶（GlcNAc T-V; EC 2.4.1.155）和特异性结合GlcNAc T-V的抗体。 本发明还提供能够与编码GlcNAc TV的核酸序列以及编码GlcNAc TV的cDNA和基因组克隆以及编码GlcNAc TV的核苷酸序列特异性杂交的多核苷酸序列和寡核苷酸探针，如GlcNAc TV编码序列 从大鼠。