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公开(公告)号：US5602003A
公开(公告)日：1997-02-11
申请号：US16863
申请日：1993-02-10
IPC分类号： A61K39/395 , C07K7/06 , C07K7/08 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/00 , C12N15/54 , C12R1/19 , C12R1/91 , G01N33/53 , C07H21/04
CPC分类号： C12N9/1051
摘要： The present invention provides a substantially purified UDP-N-acetylglucosamine:.alpha.-6-D-mannoside .beta.-1,6-N-acetylglucosaminyltransferase (GlcNAc T-V; EC 2.4.1.155) and antibodies which specifically bind GlcNAc T-V. The present invention also provides polynucleotide sequences and oligonucleotide probes capable of specifically hybridizing to nucleic acid sequences which encode GlcNAc T-V, and cDNA and genomic clones encoding GlcNAc T-V, as well as nucleotide sequences encoding GlcNAc T-V, as specifically exemplified by a GlcNAc T-V coding sequence from rat.
摘要翻译： 本发明提供基本上纯化的UDP-N-乙酰氨基葡萄糖：α-6-D-甘露糖苷β-1,6-N-乙酰葡糖胺基转移酶（GlcNAc T-V; EC 2.4.1.155）和特异性结合GlcNAc T-V的抗体。 本发明还提供能够与编码GlcNAc TV的核酸序列以及编码GlcNAc TV的cDNA和基因组克隆以及编码GlcNAc TV的核苷酸序列特异性杂交的多核苷酸序列和寡核苷酸探针，如GlcNAc TV编码序列 从大鼠。
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2.发明授权Transmembrane glycoprotein ASGP-2: nucleotide sequences and recombinant production of proteins 失效跨膜糖蛋白ASGP-2：蛋白质的核苷酸序列和重组产生
公开(公告)号：US5624816A
公开(公告)日：1997-04-29
申请号：US179481
申请日：1994-01-03
IPC分类号： A61K38/00 , C07K14/485 , C12N15/12
CPC分类号： C07K14/485 , A61K38/00
摘要： The present invention relates, in general, to a glycoprotein that is a member of the epidermal growth factor superfamily ASGP-2. In particular, the present invention relates to a DNA segment encoding the glycoprotein; to a recombinant DNA molecule containing the DNA segment; to cells containing the recombinant DNA molecule; to a method of producing the glycoprotein; and to methods of disease diagnosis and therapy that involve the use of the glycoprotein or DNA segment encoding same.
摘要翻译： 本发明一般涉及作为表皮生长因子超家族ASGP-2的成员的糖蛋白。 特别地，本发明涉及编码糖蛋白的DNA片段; 涉及含有DNA片段的重组DNA分子; 含有重组DNA分子的细胞; 涉及一种生产糖蛋白的方法; 以及涉及使用编码其的糖蛋白或DNA片段的疾病诊断和治疗方法。
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