公开(公告)号：US20110123439A1

公开(公告)日：2011-05-26

申请号：US12991503

申请日：2009-05-08

申请人： Jin Woo Cheon ,  Jin-Sil Choi ,  Jeongsoo Yoo ,  Jeong Chan Park ,  Yongmin Chang

发明人： Jin Woo Cheon ,  Jin-Sil Choi ,  Jeongsoo Yoo ,  Jeong Chan Park ,  Yongmin Chang

IPC分类号： A61K51/12

CPC分类号： A61K49/186 ,  A61K49/0002 ,  A61K49/1854 ,  A61K49/1857 ,  A61K49/1863 ,  A61K49/1869 ,  A61K49/1875 ,  A61K51/1255

摘要： The present invention relates a dual-modality PET (positron emission tomography)/MRI (magnetic resonance imaging) contrast agent, a hybrid nanoparticle comprising: (a) a magnetic signal generating core; (b) a water-soluble multi-functional ligand coated on the signal generating core; and (c) a positron emitting factor linked to the water-soluble multi-functional ligand. The contrast agent of the present invention is the dual-modality contrast agent enabling to perform PET and MR imaging and can effectively obtain images having the merits of PET (excellent sensitivity and high temporal resolution) and MR (high spatial resolution and anatomical information) imaging. The contrast agent of the present invention is very useful for non-invasive and highly sensitive real-time fault-free imaging of various biological events such as cell migration, diagnosis of various diseases (e.g., cancer diagnosis) and drug delivery.

摘要翻译： 本发明涉及双重模式PET（正电子发射断层摄影）/ MRI（磁共振成像）造影剂，混合纳米颗粒，其包括：（a）磁信号产生芯; （b）涂覆在信号产生芯上的水溶性多官能配体; 和（c）与水溶性多官能配体连接的正电子发射因子。 本发明的造影剂是能够进行PET和MR成像的双重模式对比剂，并且可以有效地获得具有PET优点（优异的灵敏度和高时间分辨率）和MR（高空间分辨率和解剖信息）成像的图像 。 本发明的造影剂对于诸如细胞迁移，各种疾病的诊断（例如癌症诊断）和药物递送的各种生物事件的非侵入性和高度灵敏度的实时无故障成像非常有用。

公开(公告)号：US20110200534A1

公开(公告)日：2011-08-18

申请号：US13059295

申请日：2009-08-21

申请人： Jin Woo Cheon ,  Jin-Sil Choi

发明人： Jin Woo Cheon ,  Jin-Sil Choi

IPC分类号： A61K49/18 ,  B82Y5/00

CPC分类号： A61K49/1869 ,  A61K49/183 ,  A61K49/1836 ,  A61K49/1854 ,  A61K49/1857 ,  A61K49/1863 ,  B82Y5/00

摘要： The present invention relates a T1-T2 dual-modal MRI (magnetic resonance imaging) contrast agent, comprising (a) a first layer consisting of T1 contrast material; (b) a second layer consisting of T2 contrast material; and (c) a separating layer which is present in a space between the first layer and the second layer, and inhibits a reciprocal interference between T1 contrast material and T2 contrast material, and a heat-generating composition and a drug delivery composition having the same. The T1-T2 dual-modal contrast agent of the present invention may generate both T1 and T2 signal and thus observe the signal complementarily, resulting in accurate diagnosis through reduction of misdiagnosis. Further, T1 and T2 MR imaging may be simultaneously obtained by simple operation within the same MR imaging device, enabling to remarkably reduce a diagnosis time and diagnosis cost. In addition, the particle constituting the T1-T2 dual-modal contrast agent of the present invention may be applied to hyperthermia and drug delivery systems.

摘要翻译： 本发明涉及一种T1-T2双模态MRI（磁共振成像）造影剂，其包含（a）由T1对比材料组成的第一层; （b）由T2造影材料组成的第二层; 和（c）分离层，其存在于第一层和第二层之间的空间中，并且抑制T1造影材料与T2造影剂材料之间的相互干涉，以及发热组合物和具有其的药物递送组合物 。 本发明的T1-T2双模造影剂可以产生T1和T2信号，从而互补地观察信号，从而通过减少误诊来进行准确的诊断。 此外，可以通过在同一MR成像装置内的简单操作同时获得T1和T2 MR成像，从而显着降低诊断时间和诊断成本。 此外，构成本发明的T1-T2双模造影剂的颗粒可以应用于高热和药物输送系统。

公开(公告)号：US08801955B2

公开(公告)日：2014-08-12

申请号：US13550082

申请日：2012-07-16

申请人： Jin-Woo Cheon ,  Young-Wook Jun ,  Jin-Sil Choi

发明人： Jin-Woo Cheon ,  Young-Wook Jun ,  Jin-Sil Choi

IPC分类号： B22F3/00 ,  C04B35/64 ,  H01F1/04 ,  C07F15/00 ,  C07C43/00 ,  A61K38/00 ,  C07K16/00 ,  C12P21/08 ,  C08F26/00 ,  C08F126/00 ,  C08F226/00 ,  C08L67/00 ,  C08L77/00 ,  C08G63/00 ,  A61K49/18 ,  A61K47/48 ,  B82Y5/00

CPC分类号： A61K47/48861 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1836 ,  A61K49/1839 ,  A61K49/1866 ,  A61K49/1875 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/795 ,  Y10S977/81 ,  Y10S977/811 ,  Y10S977/896

摘要： Disclosed are water-soluble nanoparticles. The water-soluble nanoparticles are each surrounded by a multifunctional group ligand including an adhesive region, a cross linking region, and a reactive region. In the water-soluble nanoparticles, the cross-linking region of the multifunctional group ligand is cross-linked with another cross-linking region of a neighboring multifunctional group ligand. Furthermore, the present invention provides a method of producing water-soluble nanoparticles, which includes (1) synthesizing water-insoluble nanoparticles in an organic solvent, (2) dissolving the water insoluble nanoparticles in a first solvent and dissolving water-soluble multifunctional group ligands in a second solvent, (3) mixing the two solutions from the step (2) to substitute surfaces of the water-insoluble nanoparticles with the multifunctional group ligands and dissolving a mixture in an aqueous solution to conduct a separation process, and (4) cross-linking the substituted multifunctional group ligands with each other.

摘要翻译： 公开了水溶性纳米颗粒。 水溶性纳米颗粒各自被包括粘合剂区域，交联区域和反应性区域的多官能团配体包围。 在水溶性纳米颗粒中，多官能团配体的交联区域与相邻的多官能团配体的另一个交联区域交联。 此外，本发明提供一种水溶性纳米粒子的制造方法，其特征在于，包括（1）在有机溶剂中合成水不溶性纳米粒子，（2）将水不溶性纳米粒子溶解在第一溶剂中，并溶解水溶性多官能团配体 在第二溶剂中，（3）将来自步骤（2）的两种溶液与多官能团配体的水不溶性纳米颗粒的替代表面混合，并将混合物溶解在水溶液中进行分离过程，和（4） 将取代的多官能团配体彼此交联。

公开(公告)号：US20080038361A1

公开(公告)日：2008-02-14

申请号：US11571397

申请日：2004-09-30

申请人： Jin-Woo Cheon ,  Young-Wook Jun ,  Jin-Sil Choi

发明人： Jin-Woo Cheon ,  Young-Wook Jun ,  Jin-Sil Choi

IPC分类号： B82B3/00 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/16 ,  A61K38/18 ,  A61K38/20 ,  A61K38/21 ,  A61K38/22 ,  A61K38/49 ,  A61K39/00 ,  A61K39/395 ,  A61K9/51 ,  A61P35/00 ,  A61P43/00 ,  B32B9/00

CPC分类号： A61K47/6923 ,  A61K47/6929 ,  A61K49/1836 ,  A61K49/1839 ,  A61K49/1866 ,  A61K49/1875 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/795 ,  Y10S977/81 ,  Y10S977/811 ,  Y10S977/896

摘要： Disclosed are water-soluble nanoparticles. The water-soluble nanoparticles are each surrounded by a multifunctional group ligand including an adhesive region, a cross linking region, and a reactive region. In the water-soluble nanoparticles, the cross-linking region of the multifunctional group ligand is cross-linked with another cross-linking region of a neighboring multifunctional group ligand. Furthermore, the present invention provides a method of producing water-soluble nanoparticles, which includes (1) synthesizing water-insoluble nanoparticles in an organic solvent, (2) dissolving the water insoluble nanoparticles in a first solvent and dissolving water-soluble multifunctional group ligands in a second solvent, (3) mixing the two solutions from the step (2) to substitute surfaces of the water-insoluble nanoparticles with the multifunctional group ligands and dissolving a mixture in an aqueous solution to conduct a separation process, and (4) cross-linking the substituted multifunctional group ligands with each other.

摘要翻译： 公开了水溶性纳米颗粒。 水溶性纳米颗粒各自被包括粘合剂区域，交联区域和反应性区域的多官能团配体包围。 在水溶性纳米颗粒中，多官能团配体的交联区域与相邻的多官能团配体的另一个交联区域交联。 此外，本发明提供一种水溶性纳米粒子的制造方法，其特征在于，包括（1）在有机溶剂中合成水不溶性纳米粒子，（2）将水不溶性纳米粒子溶解在第一溶剂中，并溶解水溶性多官能团配体 在第二溶剂中，（3）将来自步骤（2）的两种溶液与多官能团配体的水不溶性纳米颗粒的替代表面混合，并将混合物溶解在水溶液中进行分离过程，和（4） 将取代的多官能团配体彼此交联。