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    Water-soluble nanoparticles stabilized with multi-functional group ligands and method of preparation thereof
    1.
    发明授权
    Water-soluble nanoparticles stabilized with multi-functional group ligands and method of preparation thereof 有权
    用多官能团配体稳定的水溶性纳米颗粒及其制备方法

    公开(公告)号：US08801955B2

    公开(公告)日：2014-08-12

    申请号：US13550082

    申请日：2012-07-16

    申请人： Jin-Woo Cheon ,  Young-Wook Jun ,  Jin-Sil Choi

    发明人： Jin-Woo Cheon ,  Young-Wook Jun ,  Jin-Sil Choi

    IPC分类号： B22F3/00 ,  C04B35/64 ,  H01F1/04 ,  C07F15/00 ,  C07C43/00 ,  A61K38/00 ,  C07K16/00 ,  C12P21/08 ,  C08F26/00 ,  C08F126/00 ,  C08F226/00 ,  C08L67/00 ,  C08L77/00 ,  C08G63/00 ,  A61K49/18 ,  A61K47/48 ,  B82Y5/00

    CPC分类号： A61K47/48861 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1836 ,  A61K49/1839 ,  A61K49/1866 ,  A61K49/1875 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/795 ,  Y10S977/81 ,  Y10S977/811 ,  Y10S977/896

    摘要： Disclosed are water-soluble nanoparticles. The water-soluble nanoparticles are each surrounded by a multifunctional group ligand including an adhesive region, a cross linking region, and a reactive region. In the water-soluble nanoparticles, the cross-linking region of the multifunctional group ligand is cross-linked with another cross-linking region of a neighboring multifunctional group ligand. Furthermore, the present invention provides a method of producing water-soluble nanoparticles, which includes (1) synthesizing water-insoluble nanoparticles in an organic solvent, (2) dissolving the water insoluble nanoparticles in a first solvent and dissolving water-soluble multifunctional group ligands in a second solvent, (3) mixing the two solutions from the step (2) to substitute surfaces of the water-insoluble nanoparticles with the multifunctional group ligands and dissolving a mixture in an aqueous solution to conduct a separation process, and (4) cross-linking the substituted multifunctional group ligands with each other.

    摘要翻译： 公开了水溶性纳米颗粒。 水溶性纳米颗粒各自被包括粘合剂区域，交联区域和反应性区域的多官能团配体包围。 在水溶性纳米颗粒中，多官能团配体的交联区域与相邻的多官能团配体的另一个交联区域交联。 此外，本发明提供一种水溶性纳米粒子的制造方法，其特征在于，包括（1）在有机溶剂中合成水不溶性纳米粒子，（2）将水不溶性纳米粒子溶解在第一溶剂中，并溶解水溶性多官能团配体 在第二溶剂中，（3）将来自步骤（2）的两种溶液与多官能团配体的水不溶性纳米颗粒的替代表面混合，并将混合物溶解在水溶液中进行分离过程，和（4） 将取代的多官能团配体彼此交联。

    Water-Soluble Nanoparticles Stabilized with Multi-Functional Group Ligands and Method of Preparation Thereof
    2.
    发明申请
    Water-Soluble Nanoparticles Stabilized with Multi-Functional Group Ligands and Method of Preparation Thereof 审中-公开
    用多官能团配体稳定的水溶性纳米颗粒及其制备方法

    公开(公告)号：US20080038361A1

    公开(公告)日：2008-02-14

    申请号：US11571397

    申请日：2004-09-30

    申请人： Jin-Woo Cheon ,  Young-Wook Jun ,  Jin-Sil Choi

    发明人： Jin-Woo Cheon ,  Young-Wook Jun ,  Jin-Sil Choi

    IPC分类号： B82B3/00 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/16 ,  A61K38/18 ,  A61K38/20 ,  A61K38/21 ,  A61K38/22 ,  A61K38/49 ,  A61K39/00 ,  A61K39/395 ,  A61K9/51 ,  A61P35/00 ,  A61P43/00 ,  B32B9/00

    CPC分类号： A61K47/6923 ,  A61K47/6929 ,  A61K49/1836 ,  A61K49/1839 ,  A61K49/1866 ,  A61K49/1875 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/795 ,  Y10S977/81 ,  Y10S977/811 ,  Y10S977/896

    摘要： Disclosed are water-soluble nanoparticles. The water-soluble nanoparticles are each surrounded by a multifunctional group ligand including an adhesive region, a cross linking region, and a reactive region. In the water-soluble nanoparticles, the cross-linking region of the multifunctional group ligand is cross-linked with another cross-linking region of a neighboring multifunctional group ligand. Furthermore, the present invention provides a method of producing water-soluble nanoparticles, which includes (1) synthesizing water-insoluble nanoparticles in an organic solvent, (2) dissolving the water insoluble nanoparticles in a first solvent and dissolving water-soluble multifunctional group ligands in a second solvent, (3) mixing the two solutions from the step (2) to substitute surfaces of the water-insoluble nanoparticles with the multifunctional group ligands and dissolving a mixture in an aqueous solution to conduct a separation process, and (4) cross-linking the substituted multifunctional group ligands with each other.

    摘要翻译： 公开了水溶性纳米颗粒。 水溶性纳米颗粒各自被包括粘合剂区域，交联区域和反应性区域的多官能团配体包围。 在水溶性纳米颗粒中，多官能团配体的交联区域与相邻的多官能团配体的另一个交联区域交联。 此外，本发明提供一种水溶性纳米粒子的制造方法，其特征在于，包括（1）在有机溶剂中合成水不溶性纳米粒子，（2）将水不溶性纳米粒子溶解在第一溶剂中，并溶解水溶性多官能团配体 在第二溶剂中，（3）将来自步骤（2）的两种溶液与多官能团配体的水不溶性纳米颗粒的替代表面混合，并将混合物溶解在水溶液中进行分离过程，和（4） 将取代的多官能团配体彼此交联。