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公开(公告)号：US08273705B2
公开(公告)日：2012-09-25
申请号：US12364415
申请日：2009-02-02
申请人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译： 鉴定了调节抗凋亡蛋白（如Bcl-2和Bcl-XL）功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号：US07176277B2
公开(公告)日：2007-02-13
申请号：US11245845
申请日：2005-10-07
申请人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译： 鉴定调节抗凋亡蛋白质如Bcl-2和Bcl-XL 的功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号：US06994979B2
公开(公告)日：2006-02-07
申请号：US10735418
申请日：2003-12-11
申请人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
IPC分类号： G01N33/53
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译： 鉴定调节抗凋亡蛋白质如Bcl-2和Bcl-XL 的功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号：US07491700B2
公开(公告)日：2009-02-17
申请号：US11619965
申请日：2007-01-04
申请人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译： 鉴定了调节抗凋亡蛋白（如Bcl-2和Bcl-XL）功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号：US20090215984A1
公开(公告)日：2009-08-27
申请号：US12364415
申请日：2009-02-02
申请人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人： John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
IPC分类号： C07K14/435 , A61P35/00
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译： 鉴定出调节抗凋亡蛋白（如Bcl-2和Bcl-XL）功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号：US20070117753A1
公开(公告)日：2007-05-24
申请号：US11619965
申请日：2007-01-04
申请人： John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
发明人： John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
IPC分类号： A61K38/17
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译： 鉴定调节抗凋亡蛋白质如Bcl-2和Bcl-XL 的功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号：US20060193864A1
公开(公告)日：2006-08-31
申请号：US11245845
申请日：2005-10-07
申请人： John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
发明人： John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
IPC分类号： A61K39/395 , A61K38/17 , C07K14/705 , C07K16/30
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
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