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公开(公告)号：US20070117753A1
公开(公告)日：2007-05-24
申请号：US11619965
申请日：2007-01-04
申请人： John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
发明人： John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
IPC分类号： A61K38/17
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译： 鉴定调节抗凋亡蛋白质如Bcl-2和Bcl-XL 的功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号：US20060193864A1
公开(公告)日：2006-08-31
申请号：US11245845
申请日：2005-10-07
申请人： John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
发明人： John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
IPC分类号： A61K39/395 , A61K38/17 , C07K14/705 , C07K16/30
CPC分类号： G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
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公开(公告)号：US20130157260A1
公开(公告)日：2013-06-20
申请号：US12959054
申请日：2010-12-02
申请人： Arnold Satterthwait , Xiao-kun Zhang , Xiuwen Zhu , Siva Kolluri , John C. Reed
发明人： Arnold Satterthwait , Xiao-kun Zhang , Xiuwen Zhu , Siva Kolluri , John C. Reed
IPC分类号： G01N33/68
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/4747 , C07K14/70567
摘要： An assay for identifying compounds that affect conversion of Bcl-2 family protein from an antiapoptotic to a proapoptotic form or inhibit activity of Bcl-2 family protein is described.
摘要翻译： 描述了用于鉴定影响Bcl-2家族蛋白从抗细胞凋亡转化为促细胞凋亡形式或抑制Bcl-2家族蛋白活性的化合物的测定法。
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公开(公告)号：US20070054863A1
公开(公告)日：2007-03-08
申请号：US11433783
申请日：2006-05-11
申请人： Arnold Satterthwait , Xiao-kun Zhang , Xiuwen Zhu , Siva Kolluri
发明人： Arnold Satterthwait , Xiao-kun Zhang , Xiuwen Zhu , Siva Kolluri
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/4747 , C07K14/70567
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.
摘要翻译： 鉴定了调节抗凋亡蛋白如Bcl-2和相关Bcl-2家族成员功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述诱导或预防凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导或预防凋亡的分子的方法。 还公开了使用Bcl-2和相关家族成员的调节剂治疗增殖性疾病和神经变性疾病的方法。
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公开(公告)号：US20100292145A1
公开(公告)日：2010-11-18
申请号：US12815893
申请日：2010-06-15
申请人： Arnold Satterthwait , Xiao-kun Zhang , Xiuwen Zhu , Siva Kolluri
发明人： Arnold Satterthwait , Xiao-kun Zhang , Xiuwen Zhu , Siva Kolluri
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/4747 , C07K14/70567
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.
摘要翻译： 鉴定了调节抗凋亡蛋白如Bcl-2和相关Bcl-2家族成员功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述诱导或预防凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导或预防凋亡的分子的方法。 还公开了使用Bcl-2和相关家族成员的调节剂治疗增殖性疾病和神经变性疾病的方法。
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公开(公告)号：US07745574B2
公开(公告)日：2010-06-29
申请号：US11433783
申请日：2006-05-11
申请人： Arnold Satterthwait , Xiao-kun Zhang , Xiuwen Zhu , Siva Kolluri
发明人： Arnold Satterthwait , Xiao-kun Zhang , Xiuwen Zhu , Siva Kolluri
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/4747 , C07K14/70567
摘要： Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing or preventing apoptosis are described, together with methods for identifying molecules that induce or prevent apoptosis through interaction with Bcl-2-family members. Methods for treatment of proliferative diseases and neurodegenerative diseases using the modulators of Bcl-2 and related family members are also disclosed.
摘要翻译： 鉴定了调节抗凋亡蛋白如Bcl-2和相关Bcl-2家族成员功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述诱导或预防凋亡的方法，以及用于鉴定通过与Bcl-2家族成员相互作用诱导或预防凋亡的分子的方法。 还公开了使用Bcl-2和相关家族成员的调节剂治疗增殖性疾病和神经变性疾病的方法。
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