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公开(公告)号:US20070117753A1
公开(公告)日:2007-05-24
申请号:US11619965
申请日:2007-01-04
申请人: John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
发明人: John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
IPC分类号: A61K38/17
CPC分类号: G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译: 鉴定调节抗凋亡蛋白质如Bcl-2和Bcl-XL SUB>的功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法,以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号:US20060193864A1
公开(公告)日:2006-08-31
申请号:US11245845
申请日:2005-10-07
申请人: John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
发明人: John Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kolluri
IPC分类号: A61K39/395 , A61K38/17 , C07K14/705 , C07K16/30
CPC分类号: G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
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公开(公告)号:US08273705B2
公开(公告)日:2012-09-25
申请号:US12364415
申请日:2009-02-02
申请人: John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人: John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
CPC分类号: G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译: 鉴定了调节抗凋亡蛋白(如Bcl-2和Bcl-XL)功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法,以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号:US07176277B2
公开(公告)日:2007-02-13
申请号:US11245845
申请日:2005-10-07
申请人: John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人: John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
CPC分类号: G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译: 鉴定调节抗凋亡蛋白质如Bcl-2和Bcl-XL SUB>的功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法,以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号:US06994979B2
公开(公告)日:2006-02-07
申请号:US10735418
申请日:2003-12-11
申请人: John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人: John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
IPC分类号: G01N33/53
CPC分类号: G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译: 鉴定调节抗凋亡蛋白质如Bcl-2和Bcl-XL SUB>的功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法,以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号:US20090215984A1
公开(公告)日:2009-08-27
申请号:US12364415
申请日:2009-02-02
申请人: John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人: John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
IPC分类号: C07K14/435 , A61P35/00
CPC分类号: G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译: 鉴定出调节抗凋亡蛋白(如Bcl-2和Bcl-XL)功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法,以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号:US07491700B2
公开(公告)日:2009-02-17
申请号:US11619965
申请日:2007-01-04
申请人: John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
发明人: John C. Reed , Xiao-kun Zhang , Bin Guo , Bingzhen Lin , Siva Kumar Kolluri
CPC分类号: G01N33/5091 , A61K38/1709 , A61K38/177 , C07K16/2857 , G01N33/5008 , G01N33/5011 , G01N33/502 , G01N33/5079 , G01N2510/00
摘要: Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins from anti-apoptotic to pro-apoptotic. Methods for inducing apoptosis are described, together with methods for identifying molecules that induce apoptosis through interaction with Bcl-2-family members.
摘要翻译: 鉴定了调节抗凋亡蛋白(如Bcl-2和Bcl-XL)功能的化合物。 这些化合物具有将Bcl-2家族成员蛋白的活性从抗凋亡转化为促凋亡的能力。 描述了诱导凋亡的方法,以及用于鉴定通过与Bcl-2家族成员相互作用诱导细胞凋亡的分子的方法。
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公开(公告)号:US20140006459A1
公开(公告)日:2014-01-02
申请号:US13813646
申请日:2012-06-29
申请人: Bin Guo , Qi-Bo Ma , Yi-Ming Ruan
发明人: Bin Guo , Qi-Bo Ma , Yi-Ming Ruan
IPC分类号: G06F17/30
CPC分类号: G06F16/211 , G06F11/3684
摘要: Example embodiments disclosed herein relate to a rule-based data population system including a rule dispatcher engine to automatically bind data generating rules to a database. The system may further include a data generator engine to generate testing data for the database based on the rules.
摘要翻译: 本文公开的示例实施例涉及基于规则的数据总体系统,其包括用于自动地将数据生成规则绑定到数据库的规则分派器引擎。 该系统可以进一步包括数据生成器引擎,以基于规则为数据库生成测试数据。
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公开(公告)号:US20130319606A1
公开(公告)日:2013-12-05
申请号:US13482610
申请日:2012-05-29
申请人: Bin Guo , Wei Huang , Ching-Feng Hsieh
发明人: Bin Guo , Wei Huang , Ching-Feng Hsieh
CPC分类号: H01H13/705 , H01H13/88 , H01H2229/034 , H01H2229/042 , H01L21/67132 , H05K3/303 , H05K2203/167 , Y10T156/10
摘要: A film pasting device and method for pasting a circuit board and a dome array together are disclosed. The device includes: a carrier having at least a suction hole, a support member connected to the carrier and having a plurality of air holes, a suction member connected to the carrier, and a first positioning member disposed on the carrier. The film pasting device includes: positioning the dome array, providing a suction force for sucking the dome array so as to evenly dispose the dome array, disposing the circuit board on the dome array, and providing a pressing force to press the circuit board to the dome array. Therefore, the present invention overcomes the conventional difficulty of aligning the dome array with the circuit board, thereby improving the product yield.
摘要翻译: 公开了一种将电路板和圆顶阵列粘贴在一起的胶片粘贴装置和方法。 该装置包括:具有至少吸入孔的载体,连接到载体并具有多个气孔的支撑构件,连接到载体的抽吸构件和布置在载体上的第一定位构件。 膜贴装置包括:定位圆顶阵列,提供用于吸入圆顶阵列的吸力,以均匀地配置圆顶阵列,将电路板放置在圆顶阵列上,并提供按压力以将电路板按压到 圆顶阵列 因此,本发明克服了将圆顶阵列与电路板对准的常规难题,从而提高了产品产量。
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公开(公告)号:US07422862B2
公开(公告)日:2008-09-09
申请号:US10306878
申请日:2002-11-27
申请人: John C Reed , Bin Guo
发明人: John C Reed , Bin Guo
CPC分类号: G01N33/5011 , G01N33/5008 , G01N33/502 , G01N33/5079 , G01N33/5091 , G01N33/566 , G01N2510/00
摘要: The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound that modulates an activity of Bax or Bid. In addition, the invention provides a method of identifying a Humanin-like compound that binds to Bax or Bid or modulates an activity of Bax or Bid, or inhibits the apoptotic activity of Bax or Bid. The invention further provides an isolated polypeptide containing a mitochondrial-derived form of Humanin (SEQ ID NO:3) or a functional fragment thereof where the fragment contains the methionine at position 16 of SEQ ID NO:3.
摘要翻译: 本发明提供了鉴定调节人源蛋白与Bax或Bid的结合的有效化合物的方法。 本发明还提供了鉴定调节Bax或Bid的活性的有效化合物的方法。 此外,本发明提供了鉴定结合Bax或Bid或调节Bax或Bid的活性或抑制Bax或Bid的凋亡活性的人类素样化合物的方法。 本发明还提供了含有线粒体衍生形式的人源(SEQ ID NO:3)或其功能片段的分离的多肽,其中该片段含有SEQ ID NO:3的16位的甲硫氨酸。
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