-
公开(公告)号:US20120020918A1
公开(公告)日:2012-01-26
申请号:US13225326
申请日:2011-09-02
IPC分类号: A61K38/20 , A61P29/00 , A61P37/06 , A61P1/04 , A61P17/00 , A61P11/06 , A61P11/02 , A61P19/02 , C07K14/545 , A61P17/06
CPC分类号: C07K14/545 , A61K38/00 , A61K39/00 , C07K16/245 , C07K2317/75 , C12Q1/37 , G01N2333/545 , G01N2500/02 , G01N2500/20
摘要: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
摘要翻译: 本发明提供了涉及需要蛋白质的IL-1Rrp2的组合物和方法。
-
公开(公告)号:US20080241096A1
公开(公告)日:2008-10-02
申请号:US11900235
申请日:2007-09-10
IPC分类号: A61K38/20 , C07K14/54 , C07H21/04 , C12P21/02 , C07K16/24 , C12Q1/37 , A61P17/06 , A61K39/00 , C12N15/63 , C12N5/06
CPC分类号: C07K14/545 , A61K38/00 , A61K39/00 , C07K16/245 , C07K2317/75 , C12Q1/37 , G01N2333/545 , G01N2500/02 , G01N2500/20
摘要: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
摘要翻译: 本发明提供了涉及需要蛋白质的IL-1Rrp2的组合物和方法。
-
公开(公告)号:US08034771B2
公开(公告)日:2011-10-11
申请号:US11900235
申请日:2007-09-10
CPC分类号: C07K14/545 , A61K38/00 , A61K39/00 , C07K16/245 , C07K2317/75 , C12Q1/37 , G01N2333/545 , G01N2500/02 , G01N2500/20
摘要: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
摘要翻译: 本发明提供了涉及需要蛋白质的IL-1Rrp2的组合物和方法。
-
公开(公告)号:US08481021B2
公开(公告)日:2013-07-09
申请号:US13225326
申请日:2011-09-02
CPC分类号: C07K14/545 , A61K38/00 , A61K39/00 , C07K16/245 , C07K2317/75 , C12Q1/37 , G01N2333/545 , G01N2500/02 , G01N2500/20
摘要: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
摘要翻译: 本发明提供了涉及需要蛋白质的IL-1Rrp2的组合物和方法。
-
公开(公告)号:US08722033B2
公开(公告)日:2014-05-13
申请号:US13504449
申请日:2010-10-26
申请人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
发明人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号: C07K16/24 , A61K39/395
CPC分类号: C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译: 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白,载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
-
公开(公告)号:US09487580B2
公开(公告)日:2016-11-08
申请号:US14228556
申请日:2014-03-28
申请人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
发明人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号: A61K39/395 , C07K16/24 , A61K39/00
CPC分类号: C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译: 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白,载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
-
公开(公告)号:US20140212428A1
公开(公告)日:2014-07-31
申请号:US14228556
申请日:2014-03-28
申请人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
发明人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号: C07K16/24
CPC分类号: C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译: 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白,载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
-
公开(公告)号:US20130004501A1
公开(公告)日:2013-01-03
申请号:US13504449
申请日:2010-10-26
申请人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
发明人: Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
CPC分类号: C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要: Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译: 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白,载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
-
公开(公告)号:US20140234330A1
公开(公告)日:2014-08-21
申请号:US14234064
申请日:2012-07-20
申请人: Alison L. Budelsky , Jennifer E. Towne , Yu Zhang , Lori Siegel , Antony Symons
发明人: Alison L. Budelsky , Jennifer E. Towne , Yu Zhang , Lori Siegel , Antony Symons
IPC分类号: C07K16/28
CPC分类号: C07K16/2866 , A61K2039/505 , C07K14/54 , C07K14/7155 , C07K16/244 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要: The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor E form a heteromeric receptor complex that is biologically active, and that IL-17C activity requires the IL-17RA-IL-17RE heteromeric receptor complex. Antagonists of the IL-17RA-IL-17RE heteromeric receptor complex are disclosed, as well as various methods of use.
摘要翻译: 本发明涉及白细胞介素-17配体和受体家族成员以及IL-17受体A和IL-17受体E形成具有生物活性的异聚受体复合物的发现,并且IL-17C活性需要IL-17RA- IL-17RE异聚受体复合物。 公开了IL-17RA-IL-17RE异聚受体复合物的拮抗剂以及各种使用方法。
-
-
-
-
-
-
-
-