POLYPEPTIDES AND ANTIBODIES
    1.
    发明申请
    POLYPEPTIDES AND ANTIBODIES 审中-公开
    多肽和抗体

    公开(公告)号:US20130101589A1

    公开(公告)日:2013-04-25

    申请号:US13607384

    申请日:2012-09-07

    IPC分类号: A61K39/395

    摘要: Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand (“TRAIL”) Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.

    摘要翻译: 提供多肽。 提供结合这些多肽的抗体或抗原结合结构域。 还提供了获得结合肿瘤坏死因子(TNF)相关的凋亡诱导配体(“TRAIL”)受体-2(TR-2)的抗体的方法,包括向动物施用至少一种这样的多肽并获得抗体 其结合来自动物的TR-2。 提供与TR-2反应的抗体。 还提供产生与TR-2反应的抗体的细胞,包含与TR-2反应的抗体的药物组合物,使用与TR-2反应的抗体的方法,以及包含与TR-2反应的抗体的试剂盒。 还提供了通过施用这样的多肽来降低或预防抗体与TR-2结合的方法。

    Polypeptides and Antibodies
    10.
    发明申请
    Polypeptides and Antibodies 审中-公开
    多肽和抗体

    公开(公告)号:US20090226438A1

    公开(公告)日:2009-09-10

    申请号:US12417438

    申请日:2009-04-02

    摘要: Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand (“TRAIL”) Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.

    摘要翻译: 提供多肽。 提供结合这些多肽的抗体或抗原结合结构域。 还提供了获得结合肿瘤坏死因子(TNF)相关的凋亡诱导配体(“TRAIL”)受体-2(TR-2)的抗体的方法,包括向动物施用至少一种这样的多肽并获得抗体 其结合来自动物的TR-2。 提供与TR-2反应的抗体。 还提供产生与TR-2反应的抗体的细胞,包含与TR-2反应的抗体的药物组合物,使用与TR-2反应的抗体的方法,以及包含与TR-2反应的抗体的试剂盒。 还提供了通过施用这样的多肽来降低或预防抗体与TR-2结合的方法。