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Patent Agency Ranking
公开(公告)号：US06749125B1
公开(公告)日：2004-06-15
申请号：US10382458
申请日：2003-03-06
Applicant: Jonathan Carson , William Carson
Inventor： Jonathan Carson , William Carson
IPC: F24F708
CPC classification number: F24F7/08 , F24F2011/0002
Abstract: A central air conditioning and ventilating system has an exterior air intake duct and a plurality of dampers for opening and closing air ducts. One damper is positioned in the exterior air intake duct and a second damper is positioned in the interior of a return air duct and a third damper is positioned in the interior return air duct escape air duct. The first damper can be opened while the second damper is closed and a third damper opened to convert the air conditioning system to a whole house ventilation system.
Abstract translation: 中央空调和通风系统具有外部进气管道和用于打开和关闭空气管道的多个阻尼器。 一个阻尼器定位在外部进气管道中，并且第二阻尼器定位在回风管道的内部，并且第三阻尼器定位在内部返回空气管道逸出空气管道中。 第一阻尼器可以打开，而第二阻尼器关闭，第三阻尼器打开以将空调系统转换成整个房屋通风系统。
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公开(公告)号：US08431363B2
公开(公告)日：2013-04-30
申请号：US12812127
申请日：2009-01-09
Applicant: Thomas D. Reed , Richard E. Peterson , Charles C. Reed , Joan Mazzarelli Sopczynski , Bethany L. Merenick , Jonathan Carson , Catherine L. Bair , Elena Tasheva
Inventor： Thomas D. Reed , Richard E. Peterson , Charles C. Reed , Joan Mazzarelli Sopczynski , Bethany L. Merenick , Jonathan Carson , Catherine L. Bair , Elena Tasheva
CPC classification number: C07K14/001 , C07K14/75 , C07K14/78 , C07K14/8132 , C12N9/2451 , C12N9/6459 , C12N9/6462 , C12Y302/01099 , C12Y304/21069 , C12Y304/21073
Abstract: The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis.
Abstract translation: 本发明涉及哺乳动物PAI-1配体和调节剂。 具体地，本发明涉及编码作为PAI-1的配体和/或调节剂的多肽的多肽，多肽组合物和多核苷酸。 本发明还涉及作为调节PAI-1活性的均聚配体或杂多糖的聚合配体。 本发明还涉及位于细胞区域的配体和聚合配体。 本发明还涉及可用于提供PAI-1配体和聚合配体的空间控制的定位系链和启动子序列。 本发明还涉及可用于提供PAI-1配体和聚合配体的时间控制的可诱导基因开关。 本发明还涉及治疗或预防动脉粥样硬化的方法。 本发明还涉及治疗或预防纤维化的方法。
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公开(公告)号：US08575304B2
公开(公告)日：2013-11-05
申请号：US12532912
申请日：2008-03-27
Applicant: Thomas Reed , Amy Atzel , David Bachinsky , Jonathan Carson
Inventor： Thomas Reed , Amy Atzel , David Bachinsky , Jonathan Carson
CPC classification number: C07K14/4703 , C07K2319/00 , C12N9/1205 , C12Y207/11024 , C12Y207/12002
Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate MEK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
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公开(公告)号：US20110055940A1
公开(公告)日：2011-03-03
申请号：US12812127
申请日：2009-01-09
Applicant: Thomas D. Reed , Richard E. Peterson , Charles C. Reed , Joan Mazzarelli Sopczynski , Bethany L. Merenick , Jonathan Carson , Catherine L. Bair , Elena Tasheva
Inventor： Thomas D. Reed , Richard E. Peterson , Charles C. Reed , Joan Mazzarelli Sopczynski , Bethany L. Merenick , Jonathan Carson , Catherine L. Bair , Elena Tasheva
IPC: A61K48/00 , C07K2/00 , C07K7/08 , C07K7/06 , C07K14/435 , C12N15/12 , C12N15/85 , C12N5/10 , A01K67/027 , A61K38/02 , A61K35/00 , A61K35/12 , A61P9/00 , A61P9/10 , C12P21/02 , C12N15/873
CPC classification number: C07K14/001 , C07K14/75 , C07K14/78 , C07K14/8132 , C12N9/2451 , C12N9/6459 , C12N9/6462 , C12Y302/01099 , C12Y304/21069 , C12Y304/21073
Abstract: The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis.
Abstract translation: 本发明涉及哺乳动物PAI-1配体和调节剂。 具体地，本发明涉及编码作为PAI-1的配体和/或调节剂的多肽的多肽，多肽组合物和多核苷酸。 本发明还涉及作为调节PAI-1活性的均聚配体或杂多糖的聚合配体。 本发明还涉及位于细胞区域的配体和聚合配体。 本发明还涉及可用于提供PAI-1配体和聚合配体的空间控制的定位系链和启动子序列。 本发明还涉及可用于提供PAI-1配体和聚合配体的时间控制的可诱导基因开关。 本发明还涉及治疗或预防动脉粥样硬化的方法。 本发明还涉及治疗或预防纤维化的方法。
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公开(公告)号：US20100279378A1
公开(公告)日：2010-11-04
申请号：US12532912
申请日：2008-03-27
Applicant: David Bachinsky , Jonathan Carson , Amy Atzel , Thomas Reed
Inventor： David Bachinsky , Jonathan Carson , Amy Atzel , Thomas Reed
CPC classification number: C07K14/4703 , C07K2319/00 , C12N9/1205 , C12Y207/11024 , C12Y207/12002
Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate MEK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Abstract translation: 本发明涉及激酶配体和聚合配体。 特别地，本发明涉及调节MEK活性的配体，均聚配体和杂多糖配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体，均聚配体和杂多糖配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。
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