公开(公告)号：US20220204451A1

公开(公告)日：2022-06-30

申请号：US17605408

申请日：2020-03-05

Applicant: KANEKA CORPORATION

Inventor： Koji MACHIDA ,  Hiroaki YASUKOUCHI ,  Akira NISHIYAMA

IPC: C07D213/81

Abstract: A method for producing a first vadadustat intermediate represented by the following formula (3) comprising reacting a compound represented by the following formula (1) with glycine or a glycine derivative represented by the following formula (2) or a salt of the glycine or the glycine derivative in the presence of carbon monoxide. The method produces a vadadustat intermediate through a clean reaction with high atom conversion efficiency.

公开(公告)号：US20220025351A1

公开(公告)日：2022-01-27

申请号：US17276222

申请日：2019-09-03

Applicant: KANEKA CORPORATION

Inventor： Mirai TANAKA ,  Hiroyuki KANAMARU ,  Noriyuki ITO ,  Hiroaki YASUKOUCHI

IPC: C12N11/12 ,  C12P13/04

Abstract: An object of the present invention is to provide a method for producing an immobilized microorganism having high filtration properties, and to provide a method for producing an amino acid using the immobilized microorganism. A method for producing an immobilized microorganism is characterized in that a microorganism is contacted with carboxymethyl cellulose sodium salt and then contacted with polyethylenimine and an alkane dial after the first contact with carboxymethyl cellulose sodium salt.

公开(公告)号：US20190177262A1

公开(公告)日：2019-06-13

申请号：US16244850

申请日：2019-01-10

Applicant: KANEKA CORPORATION

Inventor： Hiroaki YASUKOUCHI ,  Makoto FUNABASHI ,  Akira NISHIYAMA ,  Toshihiro TAKEDA ,  Masaru MITSUDA

IPC: C07C68/02

Abstract: The present invention provides a method for safely producing a large amount of chloroformate compound with high yield. The chloroformate compound can be produced by mixing and reacting a solution of triphosgene, an amine and an alcohol compound in a flow reactor. The chloroformate compound can also be produced by mixing and reacting a solution of triphosgene with a solution comprising an amine and an alcohol compound in a flow reactor. The amine is preferably tributylamine, and preferably used in an amount of 0.8 to 3 equivalents relative to an amount of the alcohol compound.

公开(公告)号：US20210039064A1

公开(公告)日：2021-02-11

申请号：US16979731

申请日：2019-01-11

Applicant: KANEKA CORPORATION

Inventor： Takahiro OHISHI ,  Shiori OZASA ,  Shun WATANABE ,  Hiroaki YASUKOUCHI

IPC: B01J19/24 ,  B01J19/00

Abstract: An object is to provide a novel flow reactor capable of measuring the internal temperature. The flow reactor including a tubular reaction line, wherein the flow reactor further includes an internal temperature measurement unit provided at one or more location of the tubular reaction line, the internal temperature measurement unit includes a thermometer with a temperature sensor, and the temperature sensor is inserted into the tubular reaction line.

公开(公告)号：US20190144404A1

公开(公告)日：2019-05-16

申请号：US16244824

申请日：2019-01-10

Applicant: KANEKA CORPORATION

Inventor： Hiroaki YASUKOUCHI ,  Masaru MITSUDA ,  Akira NISHIYAMA ,  Makoto FUNABASHI

IPC: C07D301/00 ,  C07C67/14 ,  C07C231/02 ,  C07D263/44 ,  C07D471/08 ,  C07D217/06

Abstract: The present disclosure provides a reaction of a chlorine-containing compound using a flow reactor which is less restricted by a solvent to be used. In the present disclosure, an organic compound is produced by supplying a reaction substrate having at least one functional group which can react with chlorine and is selected from the group consisting of hydroxy group, a thiol group, an amino group, a carboxyl group, a thiocarboxyl group, and an acid amide group, and a chlorine-containing compound to a flow reactor together with a trialkyl amine having 9 to 40 carbon atoms and an organic solvent, and allowing the reaction substrate and the chlorine-containing compound to react with each other.