公开(公告)号：US20190192749A1

公开(公告)日：2019-06-27

申请号：US16206560

申请日：2018-11-30

Applicant: KCI Licensing, Inc.

Inventor： Christopher Brian LOCKE ,  Timothy Mark ROBINSON ,  Amy K. MCNULTY

IPC: A61M1/00

CPC classification number: A61M1/0088 ,  A61M1/0031 ,  A61M1/3687 ,  A61M27/00 ,  Y10T137/0402

Abstract: A reduced-pressure treatment system for debriding a treatment area of a tissue site and applying reduced pressure is disclosed. The reduced-pressure treatment system includes a hydrogel having a blocked acid debriding agent. The hydrogel is adapted to cover the treatment area and enhance autolytic debridement at the treatment area. The reduced-pressure treatment system includes a manifold that is adapted to cover the hydrogel and distribute reduced pressure to the tissue site. The reduce-pressure treatment system also includes a sealing drape for forming a fluid seal over the tissue site and manifold. Other systems, methods, and dressings are presented.

公开(公告)号：US20160000952A1

公开(公告)日：2016-01-07

申请号：US14851178

申请日：2015-09-11

Applicant: KCI Licensing, Inc.

Inventor： Rodolfo M. ALARCON ,  Amy K. MCNULTY

IPC: A61L2/16 ,  A61K45/06 ,  A61K39/40 ,  C07K16/12

CPC classification number: A61L2/16 ,  A61K38/48 ,  A61K39/395 ,  A61K39/40 ,  A61K45/06 ,  A61L29/16 ,  A61L2300/404 ,  A61M1/00 ,  C07K14/001 ,  C07K16/12 ,  Y02A50/475

Abstract: Methods and compositions for the treatment of biofilms and/or the inhibition of biofilm formation. In one embodiment, a biofilm is treated and/or biofilm formation is inhibited by a method comprising contacting a biofilm or a surface with a bifunctional ligand comprising a quorum-sensing-peptide-binding region and a protease-binding region, whereby the biofilm is treated and/or biofilm formation on the surface is inhibited.

Abstract translation: 用于治疗生物膜和/或抑制生物膜形成的方法和组合物。 在一个实施方案中，通过包括使生物膜或表面与包含群体感应肽结合区域和蛋白酶结合区域的双功能配体接触的方法来处理生物膜和/或生物膜形成，由此生物膜为 表面上的处理和/或生物膜形成被抑制。

公开(公告)号：US20190298872A1

公开(公告)日：2019-10-03

申请号：US16447173

申请日：2019-06-20

Applicant: KCI Licensing, Inc.

Inventor： Rodolfo M. ALARCON ,  Amy K. MCNULTY

IPC: A61L2/16 ,  A61L29/16 ,  C07K16/12 ,  A61K45/06 ,  A61K39/40 ,  A61M1/00 ,  A61K38/48 ,  C07K14/00 ,  A61K39/395

Abstract: Methods and compositions for the treatment of biofilms and/or the inhibition of biofilm formation. In one embodiment, a biofilm is treated and/or biofilm formation is inhibited by a method comprising contacting a biofilm or a surface with a bifunctional ligand comprising a quorum-sensing-peptide-binding region and a protease-binding region, whereby the biofilm is treated and/or biofilm formation on the surface is inhibited.