公开(公告)号：US20170209373A1

公开(公告)日：2017-07-27

申请号：US15361996

申请日：2016-11-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sehoon KIM ,  Youngsoo KIM ,  Youngsun KIM ,  Keunsoo JEONG ,  Ajay SINGH

IPC: A61K9/16 ,  A61K31/12 ,  A61K49/00 ,  A61K9/00

CPC classification number: A61K31/12 ,  A61K9/0019 ,  A61K9/5146 ,  A61K49/0021 ,  A61K49/0093

Abstract: The present invention relates to a drug delivery system (DDS) for crossing the blood-brain barrier (BBB) formed by self-assembly of an amphiphilic block copolymer, comprising a self-assembled structure having an average diameter of 5 nm to 20 nm of a core-shell structure comprising a hydrophobic core and a hydrophilic shell; and a hydrophobic drug supported in the hydrophobic core of the self-assembled structure, a pharmaceutical composition for preventing or treating cerebral diseases comprising the drug delivery system as an active ingredient, and a preparation method of the drug delivery system.

公开(公告)号：US20200016269A1

公开(公告)日：2020-01-16

申请号：US16395236

申请日：2019-04-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sehoon KIM ,  Youngsun KIM ,  Keunsoo JEONG ,  Gayoung KIM

IPC: A61K41/00 ,  C09B23/08 ,  C09B67/46 ,  C09B67/02 ,  C09B67/54 ,  A61N5/06

Abstract: The present invention relates to near-infrared-absorbing dye-based composite particles which exhibit a photothermal effect and/or photoacoustic signal upon photoirradiation, a preparation method thereof, and a use thereof. The near-infrared-absorbing composite particles comprise: a water-insoluble salt of a near-infrared-absorbing dye, which comprises anions of the near-infrared-absorbing dye and metal cations capable of forming a precipitation product with the anions of the near-infrared-absorbing dye; and particles of a polymeric surfactant, in which a water-insoluble salt of the near-infrared-absorbing dye is supported in the hydrophobic part of the polymeric surfactant.