公开(公告)号：US20210301241A1

公开(公告)日：2021-09-30

申请号：US17081723

申请日：2020-10-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Young Mee JUNG ,  Soo Hyun KIM ,  Justin Jihong CHUNG ,  Jin YOO ,  Tae Hee KIM

IPC: C12M1/00

Abstract: Provided are a method for fabricating a highly elastic porous polymer membrane, a method for manufacturing a cell culture system using a porous polymer membrane fabricated by the fabrication method, and a cell culture system manufactured by the manufacturing method. The porous polymer membrane can be fabricated by spin coating a mixture solution containing a biodegradable elastomeric polymer and a water-soluble moisture absorbent in an optimum ratio while maintaining a high relative humidity. The porous polymer membrane has a uniform thickness and a uniform pore size and is highly elastic. In addition, the thickness and pore size of the porous polymer membrane can be controlled. The porous polymer membrane can induce active cell-cell interaction during cell co-culture due to its high porosity. The porous polymer membrane enables control over cell alignment or array due to its high biocompatibility and elasticity. The porous polymer membrane can be utilized in a platform for inducing stem cell differentiation, a lab-on-a-chip, a synthetic skin simulant platform, etc.

公开(公告)号：US20210269602A1

公开(公告)日：2021-09-02

申请号：US17095925

申请日：2020-11-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun KIM ,  Youngmee JUNG ,  Justin Jihong CHUNG ,  Seung Hyuk IM

IPC: C08J3/03 ,  A61K9/107 ,  A61K47/34

Abstract: Provided are a method for producing a stereocomplex polylactic acid composite based on oil-in-water emulsion blending, a method for preparing a drug delivery composition using a stereocomplex polylactic acid composite produced by the production method, and a drug delivery composition prepared by the preparation method. The stereocomplex polylactic acid composite is produced using oil-in-water emulsion blending that has the advantages of simple process, short production time, and high stereocomplexation efficiency compared to existing methods such as solution blending, melt-blending, and supercritical fluid technology. In addition, the drug delivery composition is prepared using oil-in-water emulsion blending that allows the drug to be loaded into the polymer chains of the stereocomplex polylactic acid in a very easy and efficient manner and facilitates release of the drug at room temperature over a long period of time.

公开(公告)号：US20180179331A1

公开(公告)日：2018-06-28

申请号：US15717212

申请日：2017-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun KIM ,  Young Mee JUNG ,  Seung Hyuk IM

IPC: C08G63/08

CPC classification number: C08G63/08 ,  G01N25/4866

Abstract: Disclosed is a method for preparing a poly(L-lactic acid) composite. According to the method, PLLA can be processed without losing its physical properties during thermal processing and can be effectively used to manufacture a final product with improved thermal properties. In addition, the monomer is not thermally decomposed during high-temperature polymerization. Therefore, the poly(L-lactic acid) composite can be prevented from browning. Also disclosed is a poly(L-lactic acid) composite prepared by the method.

公开(公告)号：US20180353648A1

公开(公告)日：2018-12-13

申请号：US15800436

申请日：2017-11-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Young Mee JUNG ,  Soo Hyun KIM ,  Yoo Jin SEO

IPC: A61L27/36 ,  A61L27/52 ,  A61L27/24

CPC classification number: A61L27/3687 ,  A61L27/24 ,  A61L27/26 ,  A61L27/3625 ,  A61L27/3691 ,  A61L27/52 ,  C12Y301/00 ,  C12Y304/23001 ,  C12Y304/23002 ,  C08L89/00

Abstract: A method for preparing a decellularized tissue-based hydrogel with maximized ability of preserving various tissue-derived proteins, growth factors and cytokines by using a supercritical fluid-organic solvent system through (a) a step of decellularizing a biological tissue by bringing the same to contact with a supercritical fluid and an organic solvent at the same time; (b) a step of washing the decellularized tissue; (c) a step of preparing a decellularized tissue solution by mixing the washed decellularized tissue with one selected from an enzyme solution, an acidic solution and a mixture thereof; (d) a step of titrating the decellularized tissue solution to pH 5.5-7.8 by treating with a basic solution; and (e) a step of allowing the titrated decellularized tissue solution to stand at 30-40° C. and utilizing the same as a tissue engineering material with improved angiogenesis and tissue regeneration abilities.

公开(公告)号：US20180344489A1

公开(公告)日：2018-12-06

申请号：US15716620

申请日：2017-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun KIM ,  Young Mee JUNG ,  Seung Hyuk IM

IPC: A61F2/91 ,  A61L31/14 ,  A61L31/06

Abstract: A biodegradable stent and a method for preparing the same, which more particularly relate to a technology of preparing a biodegradable stent with improved flexibility and mechanical strength. The method includes a step of solid-state drawing a biodegradable filament and a step of shaping and then annealing the drawn biodegradable filament.

公开(公告)号：US20160045645A1

公开(公告)日：2016-02-18

申请号：US14514786

申请日：2014-10-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Soo Hyun KIM ,  Youngmee JUNG ,  Jin Ik LIM

IPC: A61L31/12 ,  A61L31/06 ,  A61L31/04 ,  A61L31/14

CPC classification number: A61L31/129 ,  A61L17/12 ,  A61L27/48 ,  A61L27/58 ,  A61L31/148 ,  C08L67/04

Abstract: Disclosed is a biodegradable polymer whose physical properties are improved by the presence of a stereocomplex organic filler. According to exemplary embodiments, the biodegradable polymer including a stereocomplex organic filler can find application in various fields, including biodegradable materials and medical materials, where conventional biodegradable polymers are difficult to use due to their inherent problems such as poor heat resistance and low strength. Also disclosed is a method for producing the biodegradable polymer.

Abstract translation: 公开了一种可通过立体络合物有机填料的存在改善其物理性能的可生物降解的聚合物。 根据示例性实施方案，包括立体络合物有机填料的可生物降解的聚合物可用于各种领域，包括可生物降解的材料和医疗材料，其中传统的可生物降解聚合物由于其耐热性差和强度低等固有问题而难以使用。 还公开了生物可降解聚合物的制造方法。