公开(公告)号：US11246939B2

公开(公告)日：2022-02-15

申请号：US16573351

申请日：2019-09-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sun Hwa Kim ,  Ick Chan Kwon ,  In-San Kim ,  Kwangmeyung Kim ,  Yoosoo Yang ,  Young-Ji Ko

IPC: A61K47/55 ,  A61K47/54 ,  A61K31/713 ,  C12N15/113 ,  C07K14/705 ,  A61P35/00 ,  A61K38/00

Abstract: A fusion protein-siRNA complex according to the present disclosure binds specifically to cancer cells, is taken up effectively by the cells, and exhibits anticancer activity as it is degraded by lysosomes. The fusion protein-siRNA complex provides maximized anticancer activity so that the cancer cells can be removed by autoimmunity, by inhibiting the immunity of the cancer cells and enhancing phagocytosis by macrophages.

公开(公告)号：US11884935B2

公开(公告)日：2024-01-30

申请号：US16456127

申请日：2019-06-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ick Chan Kwon ,  Sun Hwa Kim ,  Yoosoo Yang ,  Hyosuk Kim

IPC: C12N5/077

CPC classification number: C12N5/0657 ,  C12N2500/30 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2501/235 ,  C12N2501/33 ,  C12N2506/02

Abstract: The present invention relates to a method for inducing trans-differentiation of cardiomyocytes based on exosome, and more particularly, to a method for inducing trans-differentiation of a fibroblast into a cardiomyocyte, comprising the steps of: isolating exosomes in a culture medium during a process of differentiating a stem cell into the cardiomyocyte; culturing a fibroblast in a cardiomyocyte reprogramming medium containing the isolated exosomes; and culturing the fibroblast cultured in a cardiomyocyte differentiation medium containing the isolated exosomes.