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公开(公告)号：US3966830A
公开(公告)日：1976-06-29
申请号：US523049
申请日：1974-11-12
IPC分类号： B01J27/053 , B01J37/20 , B01J37/24 , C07C201/08 , C07C205/12 , C07C79/12
CPC分类号： B01J37/20 , B01J27/053 , B01J37/24 , C07C201/08
摘要： A process for nitrating halogenated benzene derivatives which comprises reacting in the vapor phase a halogenated benzene derivative with at least one member selected from the group consisting of nitric acid, nitrogen dioxide and nitrogen pentoxide in the presence of at least one solid inorganic oxide selected from the group consisting of silica, alumina and silica-alumina.
摘要翻译： 一种硝化卤代苯衍生物的方法，其包括在至少一种固体无机氧化物的存在下，在气相中使卤代苯衍生物与选自硝酸，二氧化氮和五氧化二氮的至少一种成员反应，所述固体无机氧化物选自 由二氧化硅，氧化铝和二氧化硅 - 氧化铝组成的组。
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2.发明授权Process for separating dimethyl naphthalenes comprising 2,6-dimethyl naphthalenes as main component 失效用于分离包含2,6-二甲基萘作为主要成分的二甲基萘的方法
公开(公告)号：US3936509A
公开(公告)日：1976-02-03
申请号：US520688
申请日：1974-11-04
CPC分类号： C07C7/152
摘要： A process for separating dimethyl naphthalenes having a component comprising 2,6-dimethyl naphthalene in the form of complexes with a complex-forming compound, which comprises contacting a dimethyl naphthalene isomer mixture comprising at least 2,6-dimethyl naphthalene or a hydrocarbon mixture containing said dimethyl naphthalene isomer mixture with a complex-forming compound selected from the group consisting of nitro compounds of 2,6-naphthalene dicarboxylic acid, trimellitic anhydride and 2-chloro-5-nitrobenzoic acid, thereby to form a mixture of complexes of the dimethyl naphthalenes with said complex-forming compound having a main component comprising a complex of 2,6-dimethyl naphthalene with the complex-forming compound, and separating the complexes in the solid state from the reaction mixture.
摘要翻译： 一种将具有复合物形式的2,6-二甲基萘组分的二甲基萘与络合物形成化合物分离的方法，该方法包括使包含至少2,6-二甲基萘的二甲基萘异构体混合物或含有 所述二甲基萘异构体混合物与选自2,6-萘二甲酸，偏苯三酸酐和2-氯-5-硝基苯甲酸的硝基化合物的络合物形成化合物混合，从而形成二甲基 萘与所述络合物形成化合物具有包含2,6-二甲基萘与络合物形成化合物的复合物的主要组分，并将固体状态的配合物与反应混合物分离。
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3.发明授权Surface plasmon resonance sensor chip and surface plasmon resonance sensor 失效表面等离子体共振传感器芯片和表面等离子体共振传感器公开(公告)号：US07999941B2
公开(公告)日：2011-08-16
申请号：US12282611
申请日：2007-03-14
申请人： Tomohiko Matsushita , Hideyuki Yamashita , Takeo Nishikawa , Megumi Moriyama , Ryosuke Hasui , Shigeru Aoyama
发明人： Tomohiko Matsushita , Hideyuki Yamashita , Takeo Nishikawa , Megumi Moriyama , Ryosuke Hasui , Shigeru Aoyama
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01J3/02 , G01J3/0256 , G01J3/0294
摘要： A metal layer 13 made of Au or the like is formed on the upper surface of a transparent substrate 12. Dielectric layers 14a, 14b and 14c with different thicknesses are formed on the upper surface of the metal layer 13 (any one of the dielectric layers can have a thickness of 0) to form respective determination areas 15a, 15b and 15c. Further, different types of antibodies 22a, 22b and 22c are fixed on the upper surfaces of the respective dielectric layers 14a, 14b and 14c. Then, light is directed to the determination areas 15a, 15b and 15c, then signals of light reflected by the determination areas 15a, 15b and 15c are received, the light is dispersed, and analyses are performed on signals resulted from the light dispersion to detect the conditions of the surfaces of the respective determination areas, at the same time.
摘要翻译： 在透明基板12的上表面上形成有由Au等制成的金属层13.在金属层13的上表面上形成具有不同厚度的电介质层14a，14b和14c（介电层中的任何一个 可以具有0的厚度）以形成相应的确定区域15a，15b和15c。 此外，不同类型的抗体22a，22b和22c固定在各个电介质层14a，14b和14c的上表面上。 然后，将光导向确定区域15a，15b和15c，然后接收由确定区域15a，15b和15c反射的光的信号，散射光，并且对由光散射产生的信号进行分析以检测 同时确定各个确定区域的表面条件。
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4.发明申请CHIP FOR SURFACE PLASMON RESONANCE SENSOR AND SURFACE PLASMON RESONANCE SENSOR 失效表面等离子体共振传感器和表面等离子体共振传感器的芯片公开(公告)号：US20100067015A1
公开(公告)日：2010-03-18
申请号：US12282611
申请日：2007-03-14
申请人： Tomohiko Matsushita , Hideyuki Yamashita , Takeo Nishikawa , Megumi Moriyama , Ryosuke Hasui , Shigeru Aoyama
发明人： Tomohiko Matsushita , Hideyuki Yamashita , Takeo Nishikawa , Megumi Moriyama , Ryosuke Hasui , Shigeru Aoyama
CPC分类号： G01N21/553 , G01J3/02 , G01J3/0256 , G01J3/0294
摘要： A metal layer 13 made of Au or the like is formed on the upper surface of a transparent substrate 12. Dielectric layers 14a, 14b and 14c with different thicknesses are formed on the upper surface of the metal layer 13 (any one of the dielectric layers can have a thickness of 0) to form respective determination areas 15a, 15b and 15c. Further, different types of antibodies 22a, 22b and 22c are fixed on the upper surfaces of the respective dielectric layers 14a, 14b and 14c. Then, light is directed to the determination areas 15a, 15b and 15c, then signals of light reflected by the determination areas 15a, 15b and 15c are received, the light is dispersed, and analyses are performed on signals resulted from the light dispersion to detect the conditions of the surfaces of the respective determination areas, at the same time.
摘要翻译： 在透明基板12的上表面上形成有由Au等制成的金属层13.在金属层13的上表面上形成具有不同厚度的电介质层14a，14b和14c（介电层中的任何一个 可以具有0的厚度）以形成相应的确定区域15a，15b和15c。 此外，不同类型的抗体22a，22b和22c固定在各个电介质层14a，14b和14c的上表面上。 然后，将光导向确定区域15a，15b和15c，然后接收由确定区域15a，15b和15c反射的光的信号，散射光，并且对由光散射产生的信号进行分析以检测 同时确定各个确定区域的表面条件。
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公开(公告)号：US20080037022A1
公开(公告)日：2008-02-14
申请号：US10589044
申请日：2005-02-10
CPC分类号： G01N21/554 , Y10T428/31678
摘要： In a surface plasmon resonance sensor including a chip with a substrate 102 and a metal layer 103, a prism 104, an optical system 105 serving as a light source, and a light detector 106, the metal layer 103 is configured by a flat part 109 formed into a thin film, and convex parts formed from metal particles 110 and the like arranged spaced apart from each other. When light enters the metal layer 103 of such configuration, resonance angle arising from the flat part 109 and the convex parts are respectively obtained. The change in index of refraction of a medium contacted by the metal layer is detected from such resonance angle.
摘要翻译： 在包括具有基板102和金属层103的芯片的表面等离子体共振传感器，棱镜104，用作光源的光学系统105和光检测器106中，金属层103由平坦部分109 形成为薄膜，并且由彼此间隔开设置的金属颗粒110等形成的凸部。 当光进入这种结构的金属层103时，分别获得从平坦部分109和凸起部分产生的共振角度。 从这种共振角度检测与金属层接触的介质的折射率的变化。
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6.发明申请公开(公告)号：US20070224639A1
公开(公告)日：2007-09-27
申请号：US11477153
申请日：2006-06-28
申请人： Tomohiko Matsushita , Takeo Nishikawa , Hideyuki Yamashita , Masaaki Ikeda , Shigeru Aoyama , Tetsuichi Wazawa , Hiroshi Sezaki
发明人： Tomohiko Matsushita , Takeo Nishikawa , Hideyuki Yamashita , Masaaki Ikeda , Shigeru Aoyama , Tetsuichi Wazawa , Hiroshi Sezaki
CPC分类号： G01N33/54353
摘要： A substrate for immobilizing biomolecules comprises a chip substrate, a hydrophilic monolayer, and a lipid bilayer, and a biochip comprising the substrate for immobilizing biomolecules on which biomolecules are immobilized. The substrate for immobilizing biomolecules includes a transparent chip substrate, a metal layer provided on the chip substrate, a monolayer provided on the metal layer, and a lipid bilayer provided on the monolayer. The metal layer is composed of fine particles of Au, the monolayer is composed of self-assembled molecules represented by X—(CH2)n—OH (where X is a thiol group), and the lipid bilayer is composed of self-assembled phospholipids. The monolayer and the lipid bilayer are relatively flexibly bound together via hydrogen bonds. In the biochip, a receptor is immobilized on the lipid bilayer via a biorecognition molecule.
摘要翻译： 用于固定生物分子的底物包括芯片底物，亲水性单层和脂质双层，以及包含用于固定其上固定生物分子的生物分子的底物的生物芯片。 用于固定生物分子的基板包括透明芯片衬底，设置在芯片衬底上的金属层，设置在金属层上的单层和设置在单层上的脂质双层。 金属层由Au的细颗粒构成，单层由由X（CH 2）n -OH表示的自组装分子组成（其中X为 硫醇基），脂质双层由自组装磷脂组成。 单层和脂质双层通过氢键相对灵活地结合在一起。 在生物芯片中，通过生物识别分子将受体固定在脂质双层上。
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公开(公告)号：US09331523B2
公开(公告)日：2016-05-03
申请号：US14001971
申请日：2011-03-22
申请人： Junichiro Yamada , Takeo Nishikawa , Wataru Okada
发明人： Junichiro Yamada , Takeo Nishikawa , Wataru Okada
CPC分类号： H02J9/061 , H02J3/28 , H02J3/32 , H02J7/35 , H02J9/062 , Y02B10/72 , Y02E10/566 , Y02E70/30 , Y10T307/625
摘要： A power control device is provided, the power control device comprising a first conversion part configured to convert DC voltage power into AC voltage power, the DC voltage power being output from a power generation part configured to generate power using natural energy; a second conversion part configured to convert the AC voltage power output from the first conversion part into DC voltage power; and a controller configured to control output power of the second conversion part based on a voltage value of the power output from the power generation part when supply of power from an external power system is stopped.
摘要翻译： 提供一种功率控制装置，所述功率控制装置包括被配置为将DC电压功率转换成AC电压电力的第一转换部，从被配置为使用自然能发电的发电部输出的DC电压功率; 第二转换部，被配置为将从所述第一转换部输出的交流电压电力转换成直流电压电力; 以及控制器，被配置为当来自外部电力系统的电力供应停止时，基于从所述发电部分输出的电力的电压值来控制所述第二转换部分的输出功率。
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公开(公告)号：US20080218761A1
公开(公告)日：2008-09-11
申请号：US12042910
申请日：2008-03-05
申请人： Takeo Nishikawa , Tomohiko Matsushita , Hideyuki Yamashita , Ryosuke Hasui , Satoshi Fujita , Yutaro Okuno , Shigeru Aoyama
发明人： Takeo Nishikawa , Tomohiko Matsushita , Hideyuki Yamashita , Ryosuke Hasui , Satoshi Fujita , Yutaro Okuno , Shigeru Aoyama
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , B82Y15/00 , G01N21/253 , G01N2021/0346 , G01N2021/0378 , G01N2021/0382 , G01N2021/054
摘要： A sensor chip has a metal layer formed on a surface of a substrate, where a plurality of microscopic concave part is formed in a measurement region of the surface of the metal layer. When light of linear polarization is irradiated onto the measurement region, local resonance electric field generates at opposing metal layer surfaces in the concave part. The reflected light thereof is received to measure reflectance. The light of linear polarization is irradiated so that the polarizing surface becomes orthogonal to the longitudinal direction of the concave part.
摘要翻译： 传感器芯片具有形成在基板的表面上的金属层，在金属层的表面的测量区域中形成有多个微观凹部。 当线偏振光照射在测量区域上时，在凹部的相对的金属层表面产生局部共振电场。 接收其反射光以测量反射率。 照射线偏振光，使得偏振面与凹部的长度方向正交。
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公开(公告)号：US20070211254A1
公开(公告)日：2007-09-13
申请号：US10582188
申请日：2004-12-08
申请人： Tomohiko Matsushita , Takeo Nishikawa , Yuko Tsuda , Shigemi Norioka , Tetsuichi Wazawa , Shigeru Aoyama
发明人： Tomohiko Matsushita , Takeo Nishikawa , Yuko Tsuda , Shigemi Norioka , Tetsuichi Wazawa , Shigeru Aoyama
IPC分类号： G01N21/55
CPC分类号： G01N21/7703 , G01N21/553
摘要： At both ends of a waveguide 43 having a plurality of cores 51, light emitting elements 47 and light receiving elements 49 are disposed so as to face end faces of the cores 51. A switch 44 is overlapped over the waveguide 43. In the switch 44, switching windows 52 each can be switched between a state where light propagating through the core 51 is passed and a state where the light is reflected are arranged in the vertical and horizontal directions, and the switching windows 52 are arranged along the top faces of the cores 51. A test board 45 having a plurality of channels 60 in each of which a metallic thin film 61 is formed is disposed over the switch 44, and receptors 62 are fixed on the metallic thin film 61 in the channels 60. A specimen containing a specific ligand is passed in each of the channels 60.
摘要翻译： 在具有多个芯51的波导43的两端，发光元件47和光接收元件49设置成面对芯51的端面。 开关44重叠在波导43上。 在开关44中，切换窗52各自可以在通过芯51传播的光通过的状态和反射光的状态沿垂直和水平方向布置，并且切换窗口52沿着 芯51的顶面。 具有多个通道60的测试板45中的每一个形成有金属薄膜61设置在开关44上方，并且通道60中的金属薄膜61上固定有受体62。 含有特定配体的样品通过每个通道60。
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10.发明授权公开(公告)号：US06856359B2
公开(公告)日：2005-02-15
申请号：US10422644
申请日：2003-04-24
CPC分类号： B01L3/502715 , B01L2300/0636 , B01L2300/0654 , B01L2300/0877 , G02B6/0046
摘要： A biochip includes a liquid crystal panel having liquid crystal cells each corresponding to each sample on a substrate. The liquid crystal panel includes an upper polarization filter, an upper transparent electrode, an upper orientation film, a liquid crystal, a lower orientation film, a lower transparent electrode and a lower polarization filter in this order. By application of voltage to a desired liquid crystal cell, external light is selectively radiated onto the sample. Thus, it is possible to achieve downsizing, cost reduction and high-speed operation of a biochip reader.
摘要翻译： 生物芯片包括具有各自对应于基板上的每个样品的液晶单元的液晶面板。 液晶面板依次包括上偏振滤光器，上透明电极，上取向膜，液晶，下取向膜，下透明电极和下偏振滤光器。 通过将电压施加到期望的液晶单元，外部光被选择性地辐射到样品上。 因此，可以实现生物芯片读取器的小型化，降低成本和高速运行。
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