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公开(公告)号：US06780411B2
公开(公告)日：2004-08-24
申请号：US10053316
申请日：2002-01-17
IPC分类号： A61K3800
CPC分类号： A61L24/106 , A61L24/043
摘要： Tissue sealant compositions containing human recombinant fibrinogen, human recombinant factor XIII and human recombinant thrombin. Also disclosed are preferred formulations and uses therefore.
摘要翻译： 含有人重组纤维蛋白原，人重组因子XIII和人重组凝血酶的组织密封剂组合物。 因此也公开了优选的制剂和用途。
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2.发明授权
公开(公告)号：US6144292A
公开(公告)日：2000-11-07
申请号：US727530
申请日：1996-10-21
申请人： Paul A. Brown
发明人： Paul A. Brown
CPC分类号： H04B3/54 , H02J13/0027 , H04B3/56 , H04B2203/5416 , H04B2203/5437 , H04B2203/5441 , H04B2203/5466 , Y02E60/7892 , Y04S40/146
摘要： A communications apparatus is adapted for use with a mains electricity transmission and/or distribution network. The communications apparatus includes a signal transmission and/or reception means, and frequency conversion means for converting the frequency of a signal transmitted or received by the signal transmission and/or reception means to a frequency which facilitates improved propagation of the signal on the network. Preferably the signal transmission and/or reception means is adapted to operate according to a telephony standard with uses a relatively high carrier frequency (e.g. CT2), and the frequency conversion means is usable to covert a signal having a relatively high carrier frequency (e.g. CT2) and the frequency conversion means is usable to convert a signal having a relatively high carrier frequency to a signal having a lower carrier frequency.
摘要翻译： PCT No.PCT / GB95 / 00894 Sec。 371日期1996年12月9日第 102（e）日期1996年12月9日PCT提交1995年4月20日PCT公布。 公开号WO95 / 29537 1995年11月2日日期通信设备适用于主电力传输和/或分配网络。 通信装置包括信号发送和/或接收装置，以及用于将由信号发送和/或接收装置发送或接收的信号的频率转换成促进网络上的信号的传播的频率的频率转换装置。 优选地，信号传输和/或接收装置适于根据使用相对较高载波频率（例如CT2）的电话标准进行操作，并且频率转换装置可用于对具有较高载波频率的信号（例如，CT2 ），并且频率转换装置可用于将具有较高载波频率的信号转换为具有较低载波频率的信号。
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公开(公告)号：US4673152A
公开(公告)日：1987-06-16
申请号：US837803
申请日：1986-03-10
申请人： Paul A. Brown
发明人： Paul A. Brown
CPC分类号： A47G1/215
摘要： A system for displaying and supporting record albums on a wall. The system comprises a plurality of hangers secured by nails to the wall at points generally corresponding to the corners of the record albums. The corners of the record albums are removably received by the hangers.
摘要翻译： 用于在墙上显示和支持录音相册的系统。 该系统包括多个悬挂器，其通过指甲固定到通常对应于记录相册角部的点处。 唱片专辑的角落由吊架可拆卸地接收。
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公开(公告)号：US07431539B2
公开(公告)日：2008-10-07
申请号：US11158553
申请日：2005-06-22
申请人： Robert A. Erickson , Paul A. Brown
发明人： Robert A. Erickson , Paul A. Brown
IPC分类号： B23B27/16
CPC分类号： B23B27/1662 , Y10T407/2272 , Y10T407/2276 , Y10T407/2282 , Y10T407/2292
摘要： A clamp pin tool holder for clamping an insert in a tool holder includes a bore for receiving a clamp pin and a bore for receiving a lock screw. The clamp pin includes a cam portion with angled surfaces. The lock screw is rotatably mounted to the bore of the tool holder and includes angled surfaces for engaging the angled surfaces of the clamp pin. When the lock screw is rotated in one direction, one angled surface on the lock screw and one angled surface on the clamp pin engage each other an acts as a conical wedge to cause the clamp pin to move relative to the lock screw. When the lock screw is rotated in the opposite direction, another angled surface on the lock screw engages a different angled surface on the clamp pin in a similar manner to cause the clamp pin to move in an opposite direction.
摘要翻译： 用于将插入件夹持在工具夹具中的夹紧销工具夹持器包括用于接收夹紧销的孔和用于接收锁定螺钉的孔。 夹紧销包括具有成角度表面的凸轮部分。 锁定螺钉可旋转地安装在工具夹具的孔上，并且包括用于接合夹紧销的成角度表面的成角度的表面。 当锁定螺钉沿一个方向旋转时，锁定螺钉上的一个成角度的表面和夹紧销上的一个成角度的表面彼此接合，起着锥形楔形的作用，以使夹紧销相对于锁定螺钉移动。 当锁定螺钉沿相反方向旋转时，锁定螺钉上的另一个倾斜表面以类似的方式接合夹紧销上的不同的倾斜表面，以使夹紧销沿相反的方向移动。
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5.发明授权公开(公告)号：US06564521B1
公开(公告)日：2003-05-20
申请号：US09569421
申请日：2000-05-12
IPC分类号： E04C110
CPC分类号： E04C2/292 , E04B1/6179 , E04B1/6183 , E04C2/296
摘要： Rigid structural members, profiles, joints, and forms added to structural sandwich panels to provide higher strength, integral joining joint, and single facing sheet manufacturing. Facing sheets (20) and (22), rigid structural members (24) and (26), latch side and pin side cam-locks (34) and (32), fabricated wire truss assembly (48), and rigid structural headers (28) and (30) and an integrated top plate (29) are positioned into containment form assembly (58) in the proper position. Facing sheets (20) and (22) are placed in position in the containment form assembly (58) forming a structural sandwich panel assembly. A foam resin core material (40) is injected into the structural sandwich panel assembly and allowed to cure. The resultant structural sandwich panel includes rigid structural members (24) and (26) and elongated recesses (36) and (38) which also form a joint for joining abutting structural sandwich panels together and cam-locks (32) and (34) used to secure adjoining panels together. Comer and angle panels have a comer rigid structural assembly (44).
摘要翻译： 刚性结构构件，型材，接头和形式添加到结构夹层板中，以提供更高强度，整体接合接头和单面板制造。 面板（20）和（22），刚性结构构件（24）和（26），闩锁侧和销侧凸轮锁（34）和（32），制造的钢丝绳桁架组件（48） 28）和（30）和一体化顶板（29）被定位在适当位置的容纳形式组件（58）中。 面板（20）和（22）被放置在形成结构夹层板组件的容纳形式组件（58）中的适当位置。 将泡沫树脂芯材料（40）注入结构夹芯板组件中并使其固化。 所得结构夹层板包括刚性结构构件（24）和（26）和细长凹槽（36）和（38），其也形成用于将邻接的结构夹层板连接在一起的接头和用于使用的凸轮锁（32）和（34） 将相邻的面板固定在一起。 Comer和角板具有拐角刚性结构组件（44）。
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公开(公告)号：US5614625A
公开(公告)日：1997-03-25
申请号：US417317
申请日：1995-04-05
IPC分类号： C07D401/06 , A61K20060101 , A61K31/16 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4178 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/535 , A61K31/5377 , A61K31/54 , A61K31/55 , A61P9/10 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C20060101 , C07C259/04 , C07C259/06 , C07D207/36 , C07D209/48 , C07D233/72 , C07D233/74 , C07D249/12 , C07D263/30 , C07D263/44 , C07D271/07 , C07D291/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D487/04 , C07D491/113 , C07D401/08
CPC分类号： C07D209/48 , A61K31/4178 , A61K31/454 , A61K31/5377 , C07D233/74 , C07D263/44 , C07D401/06 , C07D403/06 , C07D417/06 , C07D487/04 , Y02P20/55
摘要： The invention provides hydroxamic acid derivatives of the general formula ##STR1## wherein R.sup.1 represents cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; R.sup.2 represents a saturated 5- to 8-membered monocyclic or bridged N-heterocyclic ring, which N-heterocyclic ring is attached via the N atom and when it is monocyclic, optionally contains NR.sup.4, O, S, SO or SO.sub.2 as a ring member and/or is optionally substituted on one or more C atoms by hydroxy, lower alkyl, lower alkoxy, oxo, ketalized oxo, amino, mono(lower alkyl)amino, di(lower alkyl)amino, carboxy, lower alkoxycarbonyl, hydroxy-methyl, lower alkoxymethyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)carbamoyl or hydroxyimino; R.sup.3 represents a 5- or 6-membered N-heterocyclic ring which (a) is attached via the N atom, (b) optionally contains N, O and/or S, SO or SO.sub.2 as an additional ring member, (c) is substituted by oxo on one or both C atoms adjacent to the linking N atom and (d) is optionally benz-fused or optionally substituted on one or more other C atoms by lower alkyl or oxo and/or on any additional N atom(s) by lower alkyl or aryl; R.sup.4 represents hydrogen, lower alkyl, aryl, aralkyl or a protecting group; m stands for 1 or 2 and n stands for 1-4, pharmaceutically acceptable salts thereof, intermediates used in the manufacture thereof, and methods of use therefor. Compounds of formula I are collagenase inhibitors useful in the control or prevention of degenerative joint diseases such as rheumatoid arthritis and osteoarthritis or in the treatment of invasive tumours, atherosclerosis or multiple sclerosis.
摘要翻译： 本发明提供通式为（I）的异羟肟酸衍生物，其中R 1表示环丙基，环丁基，环戊基或环己基; R2表示饱和的5-至8-元单环或桥连的N-杂环，N-杂环通过N原子连接，当其为单环时，任选地含有作为环成员的NR4，O，S，SO或SO2 羟基，低级烷基，低级烷氧基，氧代，缩酮化的氧代，氨基，单（低级烷基）氨基，二（低级烷基）氨基，羧基，低级烷氧基羰基，羟基 - 甲基 ，低级烷氧基甲基，氨基甲酰基，单（低级烷基） - 氨基甲酰基，二（低级烷基）氨基甲酰基或羟基亚氨基; （a）经由N原子连接的5-或6-元N-杂环，（b）任选地含有N，O和/或S，SO或SO 2作为另外的环成员，（c）是 在与连接的N原子相邻的一个或两个C原子上被氧代取代，（d）任选地被苯并稠合或任选地在一个或多个其它C原子上被低级烷基或氧代和/或任何另外的N原子取代， 由低级烷基或芳基取代; R4表示氢，低级烷基，芳基，芳烷基或保护基; m代表1或2，n代表1-4，其药学上可接受的盐，制备中使用的中间体及其用途。 式I化合物是可用于控制或预防变性关节疾病如类风湿性关节炎和骨关节炎或用于治疗浸润性肿瘤，动脉粥样硬化或多发性硬化的胶原酶抑制剂。
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公开(公告)号：US5505560A
公开(公告)日：1996-04-09
申请号：US141063
申请日：1993-10-26
CPC分类号： B63B27/24 , E21B17/015 , E21B43/01
摘要： To compensate considerable movements between a floating unit and a seabed structure which are interconnected by a fluid line, the invention proposes to embody this fluid line in an upper catenary and a lower portion. The upper catenary is on the one hand supported by the floating structure and on the other hand by a subsurface buoy. The lower portion is on the one hand supported by the subsurface buoy and on the other hand connected to the seabed structure. This lower portion is provided with buoyancy beads. In this way it is possible that the floating structure may be displaced a considerable distance relative to the seabed structure. In addition, the system can withstand considerable environmental loading. This means that the connection between the seabed structure and floating unit can be maintained even under unfavorable conditions.
摘要翻译： 为了补偿由流体管线相互连接的浮动单元和海底结构之间的相当大的运动，本发明提出在上部悬链和下部中实施该流体管线。 上悬链一方面由浮式结构支撑，另一方面由地下浮标支撑。 一方面，下部部分由地下浮标支撑，另一方面连接到海底结构。 该下部设有浮力珠。 以这种方式，浮动结构可能相对于海底结构相当长的位移。 此外，该系统可以承受相当大的环境负荷。 这意味着即使在不利的条件下，海底结构和浮动单元之间的连接也可以保持。
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公开(公告)号：US07059424B2
公开(公告)日：2006-06-13
申请号：US10818003
申请日：2004-04-05
CPC分类号： B25B21/02 , B25B13/48 , B25B19/00 , B25B21/002 , B25B21/004 , B25D17/00
摘要： An apparatus for rotating a threaded tightening device includes a guide and an anvil utilized to impact a lug on the threaded tightening device to rotate the tightening device onto or off of a threaded member. The guide has a frame with a support sleeve attached thereto. A reciprocating device is received in and is supported by the support sleeve. The anvil is attached to the reciprocating device. When the reciprocating device is received in and is supported by the support sleeve, actuation of the reciprocating device will cause the anvil to repeatedly impact a lug to rotate the threaded tightening device in the desired direction.
摘要翻译： 用于旋转螺纹紧固装置的装置包括用于冲击螺纹紧固装置上的凸耳的引导件和砧座，以将紧固装置旋转到螺纹构件上或从螺纹构件脱离。 引导件具有连接有支撑套筒的框架。 往复运动装置被容纳在支撑套筒中并由支撑套筒支撑。 砧座连接在往复式装置上。 当往复运动装置被容纳在支撑套筒中并由支撑套筒支撑时，往复运动装置的致动将使砧座重复地冲击凸耳以使螺纹紧固装置沿所需方向旋转。
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9.发明授权
公开(公告)号：US5795898A
公开(公告)日：1998-08-18
申请号：US485325
申请日：1995-06-07
IPC分类号： A61K31/00 , A61K31/52 , A61K31/522 , A61K31/40 , A61K31/415 , A61K31/445
CPC分类号： A61K31/52 , A61K31/00 , A61K31/522
摘要： There is disclosed a method for: (1) inhibiting new blood vessel formation that is useful for treating or preventing progression of diabetic retinopathy, cavernous haemangiomas, Kaposi's sarcoma, tumors composed of endothelial-like cells, and growth of cancer cells by preventing their development of a new blood supply: (2) suppressing development of kidney diseases due to cytokine induced proliferation of mesangial cells and/or glomerular epithelial cells that is useful for treating or preventing progression of diabetic glomerulosclerosis and other glomerulonephritides of various types and etiologies; (3) preventing joint destruction accompanying rheumatoid arthritis due to proliferation of synovial cells; (4) suppressing manifestations of psoriasis due to proliferation of keratinocytes and accumulation of inflammatory cells; (5) suppressing accelerated atherogenesis involved in restenosis of coronary vessels or other arterial vessels following angioplasty; (6) suppressing atherogenesis, coronary artery disease and other vasculopathies due to atherogenesis; and (7) suppressing tumor growth via paracrine or autocrine mediated responses to PDGF, FGF EGF or VEGF that is useful for treating or preventing progression of tumors such as breast cancer stimulated through overexpression of her-2-neu receptor, wherein the inventive method comprises administering a compound that inhibits signal transduction through cellular accumulation of non-arachidonyl phosphatidic acid (PA) selected from the group consisting of 1-o-octadecanyl 2-oleoyl PA (687), 1-oleoyl 2-linoleoyl PA (697 or 698), 1-o-octadecanyl 2-linoleoyl PA (681), 1-o-octadecanyl-9,12-dienyl 2-linoleoyl PA (679), 1-myristoyl 2-oleoyl PA (645), 1-o-myristoyl 2-stearoyl PA (633), 1,2-sn-dilinoleoyl PA (695), 1-oleoyl 2-linoleoyl PA (697), 1-stearoyl 2-oleoyl PA (701), 1-o-oleoyl 2-20:4 PA (707), 1-o-linoleoyl 2-20:4 PA (705), 1-o-linoleoyl 2-20:5 PA (703), and combinations thereof.
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公开(公告)号：USRE42531E1
公开(公告)日：2011-07-12
申请号：US10002950
申请日：2001-10-31
CPC分类号： G09F3/0289 , C09J7/38 , C09J2201/28 , C09J2203/334 , C09J2433/00 , G09F3/10 , G09F2003/0222 , G09F2003/0272
摘要： A container is made from an elongated sheet having a front surface, a rear surface, and a first end, a second end, a top edge and a bottom edge. The sheet includes a removable portion and a remainder portion. Both the removable portion and the remainder portion have identifying indicia printed thereon. The elongated sheet is preferably made of an uniaxially oriented material. The rear surface has an adhesive coating applied thereto. An adhesive reducing coating is applied to the adhesive coating adjacent to the first end of the elongated sheet.
摘要翻译： 容器由具有前表面，后表面以及第一端，第二端，顶边和底边的细长片制成。 片材包括可移除部分和剩余部分。 可拆卸部分和剩余部分都具有印刷在其上的识别标记。 细长片优选由单轴取向材料制成。 后表面具有施加到其上的粘合剂涂层。 将粘合剂还原涂层施加到与细长片的第一端相邻的粘合剂涂层。
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