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公开(公告)号:US07678803B2
公开(公告)日:2010-03-16
申请号:US11844584
申请日:2007-08-24
申请人: Kenneth He Huang , James Veal , Thomas Barta , Emilie D. Smith , Wei Ma , Andy Ommen
发明人: Kenneth He Huang , James Veal , Thomas Barta , Emilie D. Smith , Wei Ma , Andy Ommen
IPC分类号: A61K31/517
CPC分类号: C07D403/04 , C07D401/04 , C07D401/14 , C07D471/04
摘要: The current invention is directed toward compounds and pharmaceutically acceptable salts of Formula I wherein Q1 is CR1, Q2 is N, Q4 and Q5 are each CR1, Q3 is CR2, X1 is N or CRc, Y is CRc, X2 and X3 are each C(R5)(R6), R7 is O. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer The current invention is also directed toward pharmaceutical compositions comprising compounds of the invention.
摘要翻译: 本发明涉及其中Q1是CR1,Q2是N,Q4和Q5各自是CR1,Q3是CR2,X1是N或CRc,Y是CRc,X2和X3各自为C的化合物和药学上可接受的盐 (R 5)(R 6),R 7为O.式I的化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症。本发明还涉及包含本发明化合物的药物组合物。
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公开(公告)号:US20080269193A1
公开(公告)日:2008-10-30
申请号:US12102128
申请日:2008-04-14
申请人: Kenneth He Huang , Andy J. Ommen , Thomas E. Barta , Philip F. Hughes , James Veal , Wei Ma , Emilie D. Smith , Angela R. Woodward , W. Stephen McCall
发明人: Kenneth He Huang , Andy J. Ommen , Thomas E. Barta , Philip F. Hughes , James Veal , Wei Ma , Emilie D. Smith , Angela R. Woodward , W. Stephen McCall
IPC分类号: A61K31/55 , A61K31/404 , C07D405/12 , A61K31/416 , A61P35/00 , C07D231/54 , C07D403/14
CPC分类号: C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14
摘要: The invention provides indole and indazole compounds of Formula (I) or pharmaceutically acceptable salts thereof which are useful for treating and/or preventing diseases and/or disorders ameliorated by the inhibition of Heat-Shock Protein 90. The invention further provides pharmaceutical compositions comprising compounds of Formula (I) and methods of preparing compounds of Formula (I).
摘要翻译: 本发明提供了可用于治疗和/或预防通过抑制热休克蛋白90改善的疾病和/或障碍的式(I)的吲哚和吲唑化合物或其药学上可接受的盐。本发明还提供包含化合物 的式(I)化合物和式(I)化合物的制备方法。
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公开(公告)号:US20110183977A1
公开(公告)日:2011-07-28
申请号:US13081637
申请日:2011-04-07
申请人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: A61K31/5377 , A61K31/454 , A61K31/415 , A61K31/405 , C07D413/12 , C07D401/12 , C07D403/12 , C07D209/04 , A61P31/10 , C07D409/12 , C07D405/12 , A61P29/00 , A61P35/00 , A61P31/00 , A61P19/02 , A61P37/00 , A61P25/00 , A61P9/00 , A61P35/02 , A61P3/00 , A61P11/00
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
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公开(公告)号:US20080119457A1
公开(公告)日:2008-05-22
申请号:US11844816
申请日:2007-08-24
申请人: Kenneth He Huang , John Mangette , Thomas Barta , Steven E. Hall , James Veal , Philip Hughes
发明人: Kenneth He Huang , John Mangette , Thomas Barta , Steven E. Hall , James Veal , Philip Hughes
IPC分类号: A61K31/55 , A61K31/551 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/501 , C07D413/02 , C07D403/02
CPC分类号: C07D207/02 , C07D209/04 , C07D231/22 , C07D231/38 , C07D231/56 , C07D333/22 , C07D471/04 , C07D487/04 , C07D491/04
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R31, and R41 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中A,Q 1,Q 2,Q 3,R 31, SUB>和R 41'如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号:US07928135B2
公开(公告)日:2011-04-19
申请号:US12907571
申请日:2010-10-19
申请人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: C07D231/54 , A01N43/56
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
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公开(公告)号:US20110034529A1
公开(公告)日:2011-02-10
申请号:US12907571
申请日:2010-10-19
申请人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: A61K31/416 , C07D231/56 , A61P35/00
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中R1,R2,R3,R4,R5,R6,R7,n,Q1,Q2,Q3,Y和X1-X4如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号:US07358370B2
公开(公告)日:2008-04-15
申请号:US11363449
申请日:2006-02-27
申请人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: C07D231/54 , A01N43/56
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中R 1,R 2,R 3,R 4, R 5,R 6,R 7,n,Q 1,Q 2, 3,Q 3,Y和X 1 -X 4个如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号:US08309548B2
公开(公告)日:2012-11-13
申请号:US13081637
申请日:2011-04-07
申请人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: A61K31/5377 , A61K31/454 , A61K31/415 , A61K31/405 , C07D413/12 , C07D401/12 , C07D403/12 , C07D209/04
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中R1,R2,R3,R4,R5,R6,R7,n,Q1,Q2,Q3,Y和X1-X4如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号:US07906529B2
公开(公告)日:2011-03-15
申请号:US11959784
申请日:2007-12-19
申请人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: C07D209/00 , A01N43/42
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中R1,R2,R3,R4,R5,R6,R7,n,Q1,Q2,Q3,Y和X1-X4如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号:US20080096887A1
公开(公告)日:2008-04-24
申请号:US11959784
申请日:2007-12-19
申请人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61P19/02 , A61P25/00 , A61P29/00 , A61P3/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P9/00 , C07D209/08 , C07D231/56 , C07D401/02 , C07D405/02 , C07D409/02 , C07D413/02
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中R 1,R 2,R 3,R 4, R 5,R 6,R 7,n,Q 1,Q 2, 3,Q 3,Y和X 1 -X 4个如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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