Quinazoline derivatives for the treatment of cancer
    1.
    发明授权
    Quinazoline derivatives for the treatment of cancer 有权
    喹唑啉衍生物用于治疗癌症

    公开(公告)号:US07678803B2

    公开(公告)日:2010-03-16

    申请号:US11844584

    申请日:2007-08-24

    IPC分类号: A61K31/517

    摘要: The current invention is directed toward compounds and pharmaceutically acceptable salts of Formula I wherein Q1 is CR1, Q2 is N, Q4 and Q5 are each CR1, Q3 is CR2, X1 is N or CRc, Y is CRc, X2 and X3 are each C(R5)(R6), R7 is O. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer The current invention is also directed toward pharmaceutical compositions comprising compounds of the invention.

    摘要翻译: 本发明涉及其中Q1是CR1,Q2是N,Q4和Q5各自是CR1,Q3是CR2,X1是N或CRc,Y是CRc,X2和X3各自为C的化合物和药学上可接受的盐 (R 5)(R 6),R 7为O.式I的化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症。本发明还涉及包含本发明化合物的药物组合物。