摘要:
According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method.
摘要:
According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method.
摘要:
The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.
摘要:
The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.
摘要:
Disclosed is a method of manufacturing soundproofing composite, and a soundproofing composite manufactured by the aforementioned method, the method comprising preparing a mixture by dissolving PP resin and nanoclay in a solvent; and volatilizing the solvent from the mixture. According to the present invention, the composite is manufactured by dissolving PP resin and nanoclay, to thereby realize great stiffness and soundproofing properties.
摘要:
Provided is an improved method for stereoselectively preparing 2′-deoxy-2′,2′-difluorocytidine of formula (I), which includes reacting a 1-halo ribofuranose compound with a nucleobase of formula (IV) in a solvent to obtain a nucleo side of formula (II) with removal of a silyl halide ((alkyl)3SiX (X=halide)); and deprotecting the nucleoside of formula (II) to obtain 2′-deoxy-2′,2′-difluorocytidine of formula (I). 2′-Deoxy-2′,2′-difluorocytidine of formula (I) is effective for treating various cancers such as non-small cell lung (NSCLC), pancreatic, bladder, breast or ovarian cancers.
摘要:
An apparatus and method for coating a powder material on a substrate is disclosed, to enable various materials such as metal or ceramic powder to be coated on a substrate made of a material having low heat-resistance, the method including supplying a predetermined powder; carrying the supplied powder to a predetermined spraying nozzle by injecting a gas at a room temperature; and spraying the powder carried under conditions of the room temperature and vacuum state on the substrate through spraying nozzle, wherein the grain size of predetermined powder is in a range between about 0.1 to about 10 μm, and the powder is sprayed on the substrate at a velocity of about 500 to about 1200 m/sec.
摘要:
A process for manufacturing an Al—Si alloy for use in a vehicle propeller shaft is provided. The Al—Si alloy manufacturing process includes the steps of heating and melting Al—Si alloy where Si contains 13-40 weight percentage (wt %) of the whole alloy, to thereby prepare melt, maintaining the melt at 700-900° C. and then spraying an high pressure inert gas to the melt and rapidly solidifying the same to thereby obtain a forming body, and extruding the forming body at 400-550° C. The physical properties of the Al—Si alloy manufactured by a spray forming process is at least similar to that of the vehicle propeller shafts which have been already known, and also spotlighted as new alloy compositions which can replace the conventional propeller shaft material.
摘要:
A washing machine and associated washing method are provided. The method may include rotating a drum, measuring and storing a vibration level of a cabinet while increasing a rotational speed of the drum, and measuring the vibration level of the cabinet after the rotational speed of the drum reaches a target rotational speed and determining whether or not the vibration level of the cabinet is greater than a set value. The method may then include adjusting the rotational speed of the drum if the vibration level is greater than the set value so as to minimize vibration and resonance in a support surface on which the washing machine is positioned.
摘要:
There is provided a multi-turn hydraulic actuator used to open/close a passageway in ground and sea industries including general industrial machines, oil refineries and chemical plants and power generating plants, among others, and more particularly, a multi-turn hydraulic actuator comprising: a hydraulic motor and a decelerator, among others, whereby high torque is efficiently obtained by using low electric power, compared to a conventional electric actuator, and whereby an operation part and a drive part are freely attached to/detached from at a user's necessity.In the multi-turn hydraulic actuator, the hydraulic motor is driven by using hydraulic pressure generated by a hydraulic pressure generator, a rotational force of the hydraulic motor is transmitted to a worm shaft of the decelerator directly connected to the hydraulic motor so that a driving shaft is rotated in a reduced speed, and the rotation of the worm shaft is selectively manually operated by setting a manual mode switch and using a manual handle.