公开(公告)号：US09944981B2

公开(公告)日：2018-04-17

申请号：US13797865

申请日：2013-03-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jonathan Rothberg ,  Wolfgang Hinz ,  John Davidson ,  Antoine van Oijen ,  John Leamon ,  Martin Huber

IPC: G01N27/00 ,  C12Q1/68 ,  G01N27/414 ,  H01L21/82

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82 ,  C12Q2565/607

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

公开(公告)号：US20190079047A1

公开(公告)日：2019-03-14

申请号：US16101337

申请日：2018-08-10

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jonathan M. Rothberg ,  Wolfgang Hinz ,  John F. Davidson ,  Antoine M. van Oijen ,  John Leamon ,  Martin Huber

IPC: G01N27/414 ,  H01L21/82 ,  C12Q1/6869 ,  C12Q1/6874

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

公开(公告)号：US11874250B2

公开(公告)日：2024-01-16

申请号：US17823696

申请日：2022-08-31

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jonathan M. Rothberg ,  Wolfgang Hinz ,  John F. Davidson ,  Antoine M. van Oijen ,  John Leamon ,  Martin Huber ,  Mark James Milgrew ,  James Bustillo

IPC: G01N27/414 ,  C12Q1/6874 ,  H01L21/82 ,  C12Q1/6869

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82 ,  C12Q1/6874 ,  C12Q2565/607

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

公开(公告)号：US11448613B2

公开(公告)日：2022-09-20

申请号：US16101337

申请日：2018-08-10

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jonathan M. Rothberg ,  Wolfgang Hinz ,  John F. Davidson ,  Antoine M. van Oijen ,  John Leamon ,  Martin Huber ,  Mark James Milgrew ,  James Bustillo

IPC: G01N27/414 ,  C12Q1/6874 ,  H01L21/82 ,  C12Q1/6869

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

公开(公告)号：US20130210128A1

公开(公告)日：2013-08-15

申请号：US13797865

申请日：2013-03-12

Applicant: Life Technologies Corporation

Inventor： Jonathan ROTHBERG ,  Wolfgang Hinz ,  John Davidson ,  Antoine van Oijen ,  John Leamon ,  Martin Huber

IPC: G01N27/414

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82 ,  C12Q2565/607

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

公开(公告)号：US12146853B2

公开(公告)日：2024-11-19

申请号：US18536131

申请日：2023-12-11

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： James Bustillo ,  Mark J. Milgrew ,  Wolfgang Hinz ,  John Leamon ,  John Davidson ,  Martin Huber ,  Antoine M. van Oijen ,  Jonathan Rothberg

IPC: G01N27/414 ,  C12Q1/6869 ,  C12Q1/6874 ,  H01L21/82

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

公开(公告)号：US20130210182A1

公开(公告)日：2013-08-15

申请号：US13797871

申请日：2013-03-12

Applicant: Life Technologies Corporation

Inventor： Jonathan ROTHBERG ,  Wolfgang Hinz ,  John Davidson ,  Antoine van Oijen ,  John Leamon ,  Martin Huber

IPC: H01L21/82

CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N27/4148 ,  H01L21/82 ,  C12Q2565/607

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

Abstract translation: 与用于监测化学和/或生物反应的FET阵列相关的方法和装置，例如核酸序列合成反应。 本文提供的一些方法涉及在核酸测序反应期间从释放的氢离子改进信号（以及信噪比）。