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公开(公告)号：US11879156B2
公开(公告)日：2024-01-23
申请号：US17818869
申请日：2022-08-10
发明人： Phil Waggoner , James A. Ball , Wolfgang Hinz , Michael L. Minto , Scott Parker , David M. Cox , Alexander Mastroianni , Jeremy Gray , Marc Glazer , Kimberly Gorrell
IPC分类号： G01N27/414 , C12Q1/6869
CPC分类号： C12Q1/6869 , G01N27/4145 , C12Q1/6869 , C12Q2527/119 , C12Q2527/125 , C12Q2565/607
摘要： A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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公开(公告)号：US11319587B2
公开(公告)日：2022-05-03
申请号：US16292087
申请日：2019-03-04
发明人： Wolfgang Hinz , David Light , Todd Rearick , James A. Ball
IPC分类号： C12Q1/6874 , G01N27/414
摘要： The disclosure relates to novel particle compositions and methods of making said compositions having applications in nucleic acid analysis, as well as apparatuses and systems for the same.
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公开(公告)号：US20200216893A1
公开(公告)日：2020-07-09
申请号：US16824920
申请日：2020-03-20
发明人： Phil Waggoner , James A. Ball , Wolfgang Hinz , Michael L. Minto , Scott Parker , David M. Cox , Alexander Mastroianni , Jeremy Gray , Marc Glazer , Kimberly Gorrell
IPC分类号： C12Q1/6869 , G01N27/414
摘要： A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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公开(公告)号：US10246533B2
公开(公告)日：2019-04-02
申请号：US14970192
申请日：2015-12-15
发明人： Geir Fonnum , Grete Irene Modahl , Nini Hofslokken Kjus , Astrid Evenroed Molteberg , Diem Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC分类号： C08F130/08 , C08F6/24 , C07F7/18 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C08F8/34 , C12Q1/686 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20 , C08F8/12
摘要： A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of monomer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US10066260B2
公开(公告)日：2018-09-04
申请号：US14774662
申请日：2014-03-13
发明人： David Light , Wolfgang Hinz , Ronald L. Cicero , Christina E. Inman , Paul M. Kenney , Alexander Mastroianni , Roman Rozhkov , Yufang Wang , Jeremy Gray , Marc Glazer , Dmitriy Gremyachinskiy
IPC分类号： C12Q1/6837 , C12Q1/6806 , C12Q1/6869
CPC分类号： C12Q1/6837 , C12Q1/6806 , C12Q1/6834 , C12Q1/6869 , C12Q2523/101 , C12Q2527/119 , C12Q2535/122 , C12Q2547/107 , C12Q2563/159 , C12Q2565/537 , C12Q2523/301 , C12Q2523/32
摘要： A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array.
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公开(公告)号：US10059987B2
公开(公告)日：2018-08-28
申请号：US15625800
申请日：2017-06-16
IPC分类号： C12N9/12 , C12Q1/6869 , G01N27/414
CPC分类号： C12Q1/6869 , C12N9/1252 , C12Y207/07007 , G01N27/4145
摘要： Methods, compositions, systems, apparatuses and kits comprising modified proteins, particularly modified nucleic acid-binding proteins with altered buffering properties are provided. For example, in some embodiments, methods of forming modified proteins including one or more amino acid modifications to achieve desired pKa values are described. Furthermore, the invention provides methods for using such modified proteins in ion-producing reactions, such as ion-based nucleic acid sequencing reactions.
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公开(公告)号：US09944981B2
公开(公告)日：2018-04-17
申请号：US13797865
申请日：2013-03-12
发明人： Jonathan Rothberg , Wolfgang Hinz , John Davidson , Antoine van Oijen , John Leamon , Martin Huber
IPC分类号： G01N27/00 , C12Q1/68 , G01N27/414 , H01L21/82
CPC分类号： G01N27/4145 , C12Q1/6869 , C12Q1/6874 , G01N27/4148 , H01L21/82 , C12Q2565/607
摘要： Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.
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公开(公告)号：US09868826B2
公开(公告)日：2018-01-16
申请号：US15200533
申请日：2016-07-01
发明人： Geir Fonnum , Steven M. Menchen , Talha M. Gokmen , Pontus Lundberg , Prasanna Krishnan Thwar , Alfred Lui , Lily Lu , Wolfgang Hinz , Lene Husaboe , Elisabeth Breivold , Astrid Evenroed Molteberg , Synne Larsen
IPC分类号： C08J3/075 , C08F220/58 , C08F8/12 , C08F220/70 , C08F230/08
CPC分类号： C08J3/075 , C08F8/12 , C08F220/58 , C08F220/70 , C08F2230/085 , C08J2333/26 , C08F222/38
摘要： A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
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公开(公告)号：US09852919B2
公开(公告)日：2017-12-26
申请号：US14676697
申请日：2015-04-01
IPC分类号： H01L21/00 , H01L21/311 , G01N27/414
CPC分类号： H01L21/31105 , G01N27/4145 , H01L21/31144
摘要： A method of manufacturing a sensor, the method including forming an array of chemically-sensitive field effect transistors (chemFETs), depositing a dielectric layer over the chemFETs in the array, depositing a protective layer over the dielectric layer, etching the dielectric layer and the protective layer to form cavities corresponding to sensing surfaces of the chemFETs, and removing the protective layer. The method further includes, etching the dielectric layer and the protective layer together to form cavities corresponding to sensing surfaces of the chemFETs. The protective layer is at least one of a polymer, photoresist material, noble metal, copper oxide, and zinc oxide. The protective protective layer is removed using at least one of sodium hydroxide, organic solvent, aqua regia, ammonium carbonate, hydrochloric acid, acetic acid, and phosphoric acid.
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公开(公告)号：US09778221B2
公开(公告)日：2017-10-03
申请号：US15331779
申请日：2016-10-21
发明人： Kristopher Barbee , John Davidson , Wolfgang Hinz , Shifeng Li , James Bustillo
IPC分类号： G01N27/447 , B01J19/00 , G01N27/414 , C12Q1/68
CPC分类号： G01N27/4473 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00704 , B01J2219/00722 , C12Q1/6874 , G01N27/4145 , G01N27/4148 , G01N27/44743
摘要： An apparatus includes a device substrate including an array of sensors. Each sensor of the array of sensors can include a electrode structure disposed at a surface of the device substrate. The apparatus further includes a wall structure overlying the surface of the device substrate and defining an array of wells at least partially corresponding with the array of sensors. The well structure including an electrode layer and an insulative layer.
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