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公开(公告)号：US10252272B2
公开(公告)日：2019-04-09
申请号：US14893356
申请日：2014-05-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael Pallas , Evan Foster , Jorge Fonseca , James Nurse , Theodore Straub
Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The support is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.
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公开(公告)号：US10994275B2
公开(公告)日：2021-05-04
申请号：US16291757
申请日：2019-03-04
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael Pallas , Evan Foster , Jorge Fonseca , James Nurse , Theodore Straub
Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The suppose is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.
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公开(公告)号：US20160271604A1
公开(公告)日：2016-09-22
申请号：US15037471
申请日：2014-11-18
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Gary Lim , Theodore Straub
CPC classification number: B01L3/0293 , B01L3/50857 , B01L2200/026 , B01L2200/0642 , B01L2300/0829 , B01L2300/0893 , B01L2300/12 , B01L2400/0406 , C12Q1/686
Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85+/−15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action. The first and second blade may dispense the liquid by laterally moving over the plurality of reaction sites, where a motor laterally moves the first and second blade.
Abstract translation: 提供了一种用于将液体样品加载到基底内的多个反应位点的样品装载器。 样品装载器包括第一叶片和联接到第一叶片的第二叶片。 样品装载器还包括在第一叶片和第二叶片之间的流动路径，其构造成将液体样品分配到包括多个反应位点的基底。 此外，在各种实施例中，液体样品与第一和第二叶片具有85 +/- 15度的前进接触角。 此外，从流动路径分配到多个反应位点的液体样品的装载可以基于毛细作用。 第一和第二叶片可以通过横向移动多个反应部位来分配液体，其中马达横向移动第一和第二叶片。
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