公开(公告)号：US06211224B1

公开(公告)日：2001-04-03

申请号：US09178688

申请日：1998-10-26

申请人： Lin Chu ,  Mark Goulet ,  Thomas F. Walsh ,  Matthew J. Wyvratt ,  Stephanie L. Witkin

发明人： Lin Chu ,  Mark Goulet ,  Thomas F. Walsh ,  Matthew J. Wyvratt ,  Stephanie L. Witkin

IPC分类号： A61K31404

CPC分类号： C07D209/14

摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

摘要翻译： 公开了式（I）化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗男性和女性中各种性激素相关和其他病症。

公开(公告)号：US6159989A

公开(公告)日：2000-12-12

申请号：US465199

申请日：1999-12-15

申请人： Lin Chu ,  Mark Goulet ,  Thomas F. Walsh ,  Matthew J. Wyvratt ,  Stephanie L. Witkin

发明人： Lin Chu ,  Mark Goulet ,  Thomas F. Walsh ,  Matthew J. Wyvratt ,  Stephanie L. Witkin

IPC分类号： A61P15/08 ,  C07D453/06 ,  C07D487/08 ,  A61K31/405 ,  A61K31/454 ,  C07D211/26 ,  C07D401/14

CPC分类号： C07D487/08 ,  C07D453/06

摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

公开(公告)号：US6017944A

公开(公告)日：2000-01-25

申请号：US178689

申请日：1998-10-26

申请人： Lin Chu ,  Thomas F. Walsh ,  Mark Goulet ,  Matthew J. Wyvratt ,  Stephanie L. Witkin

发明人： Lin Chu ,  Thomas F. Walsh ,  Mark Goulet ,  Matthew J. Wyvratt ,  Stephanie L. Witkin

IPC分类号： A61P15/08 ,  C07D453/06 ,  C07D487/08 ,  A61K31/40 ,  A61K31/405 ,  C07D209/02 ,  C07D209/12 ,  C07D403/10

CPC分类号： C07D487/08 ,  C07D453/06

摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.