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公开(公告)号：US06211224B1
公开(公告)日：2001-04-03
申请号：US09178688
申请日：1998-10-26
IPC分类号： A61K31404
CPC分类号： C07D209/14
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
摘要翻译： 公开了式（I）化合物及其药学上可接受的盐，其可用作GnRH的拮抗剂，因此可用于治疗男性和女性中各种性激素相关和其他病症。
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公开(公告)号：US6159989A
公开(公告)日：2000-12-12
申请号：US465199
申请日：1999-12-15
IPC分类号： A61P15/08 , C07D453/06 , C07D487/08 , A61K31/405 , A61K31/454 , C07D211/26 , C07D401/14
CPC分类号： C07D487/08 , C07D453/06
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US6017944A
公开(公告)日：2000-01-25
申请号：US178689
申请日：1998-10-26
IPC分类号： A61P15/08 , C07D453/06 , C07D487/08 , A61K31/40 , A61K31/405 , C07D209/02 , C07D209/12 , C07D403/10
CPC分类号： C07D487/08 , C07D453/06
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US5849764A
公开(公告)日：1998-12-15
申请号：US760817
申请日：1996-12-05
申请人： Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
发明人： Mark Goulet , Lin Chu , Thomas F. Walsh , Michael H. Fisher , Narindar N. Girotra , Matthew J. Wyvratt , Peter Lin , Wallace T. Ashton
IPC分类号： C07D20060101 , C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04 , A61K31/44 , A61K31/40 , C07D209/02 , C07D215/12
CPC分类号： C07D209/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US06077858A
公开(公告)日：2000-06-20
申请号：US401416
申请日：1999-09-21
申请人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号： C07D409/14 , C07D487/08 , A61K31/44
CPC分类号： C07D409/14 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US5985901A
公开(公告)日：1999-11-16
申请号：US83479
申请日：1998-05-22
申请人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人： Mark Goulet , Feroze Ujjainwalla , Thomas F. Walsh , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D521/00 , A61K31/44
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D413/12
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US5981550A
公开(公告)日：1999-11-09
申请号：US83574
申请日：1998-05-22
申请人： Mark Goulet , Thomas F. Walsh , Feroze Ujjainwalla , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
发明人： Mark Goulet , Thomas F. Walsh , Feroze Ujjainwalla , Matthew J. Wyvratt, Jr. , Jonathan R. Young , Lin Chu
IPC分类号： C07D409/14 , C07D487/08 , C07D401/12 , A61K31/44
CPC分类号： C07D409/14 , C07D487/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US6150352A
公开(公告)日：2000-11-21
申请号：US180662
申请日：1998-11-12
申请人： Mark Goulet , Eric E Allen , Matthew J. Wyvratt, Jr. , Jinlong Jiang , Richard B. Toupence , Thomas F Walsh , Feroze Ujjainwalla , Jonathan R Young , Robert J. Devita
发明人： Mark Goulet , Eric E Allen , Matthew J. Wyvratt, Jr. , Jinlong Jiang , Richard B. Toupence , Thomas F Walsh , Feroze Ujjainwalla , Jonathan R Young , Robert J. Devita
IPC分类号： C07D473/00 , A61K31/00 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/529 , A61P5/00 , A61P5/06 , A61P5/24 , A61P15/00 , A61P25/20 , A61P35/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D453/02 , C07D473/32 , C07D487/04 , C07D487/08 , C07D495/04 , C07D31/47
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D451/02 , C07D473/32 , C07D487/04 , C07D495/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions in both men and women.
摘要翻译： PCT No.PCT / US97 / 08432 Sec。 371日期：1998年11月12日 102（e）1998年11月12日日期PCT提交1997年5月16日PCT公布。 公开号WO97 / 44339 日期1997年11月27日公开了可用作GnRH拮抗剂的式（I）化合物及其药学上可接受的盐，因此可用于治疗男性和女性中各种性激素相关病症。
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公开(公告)号：US6156772A
公开(公告)日：2000-12-05
申请号：US312192
申请日：1999-05-14
IPC分类号： A61K45/06 , C07D401/12 , C07D401/14 , C07D491/08 , A01N43/40 , A01N43/38 , C07D209/02 , C07D401/00 , C07D405/00
CPC分类号： C07D401/12 , A61K45/06 , C07D401/14 , C07D491/08
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US6147088A
公开(公告)日：2000-11-14
申请号：US180645
申请日：1998-11-12
申请人： Mark Goulet , Eric E Allen , Matthew J. Wyvratt, Jr. , Jinlong Jiang , Roy G. Smith , Thomas F Walsh , Yi Tien Yang , Jonathan R Young , Robert J. Devita
发明人： Mark Goulet , Eric E Allen , Matthew J. Wyvratt, Jr. , Jinlong Jiang , Roy G. Smith , Thomas F Walsh , Yi Tien Yang , Jonathan R Young , Robert J. Devita
IPC分类号： A61P5/02 , C07D215/22 , C07D215/36 , C07D215/46 , C07D401/06 , C07D401/12 , C07D413/12 , C07D453/02 , C07D471/08 , A61K31/4704 , A61K31/4709 , C07D215/20 , C07D215/227
CPC分类号： C07D215/22 , C07D215/36 , C07D215/46 , C07D401/06 , C07D401/12 , C07D413/12 , C07D453/02 , C07D471/08
摘要： There are disclosed compounds of formula (I) and pharmaceutical acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related conditions. ##STR1##
摘要翻译： PCT No.PCT / US97 / 08479 Sec。 371日期：1998年11月12日 102（e）1998年11月12日日期PCT提交1997年5月16日PCT公布。 WO97 / 44321 PCT出版物 日期1997年11月27日公开了可用作GnRH拮抗剂的式（I）化合物及其药学上可接受的盐，因此可用于治疗各种性激素相关病症。
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