公开(公告)号：US20070027071A1

公开(公告)日：2007-02-01

申请号：US11484925

申请日：2006-07-12

申请人： M. Holloway ,  Nigel Liverton ,  Steven Ludmerer ,  John McCauley ,  David Olsen ,  Michael Rudd ,  Joseph Vacca ,  Charles McIntyre

发明人： M. Holloway ,  Nigel Liverton ,  Steven Ludmerer ,  John McCauley ,  David Olsen ,  Michael Rudd ,  Joseph Vacca ,  Charles McIntyre

IPC分类号： A61K38/12 ,  C07K5/12

CPC分类号： C07K5/0808 ,  A61K38/00 ,  C07K5/0812 ,  C07K5/0827

摘要： The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS3蛋白酶抑制剂及其合成及其用于治疗或预防HCV感染的用途的式（I）的大环化合物。

公开(公告)号：US20080015233A1

公开(公告)日：2008-01-17

申请号：US11547994

申请日：2005-04-20

申请人： James Barrow ,  Georgia McGaughey ,  Philippe Nantermet ,  Hemaka Rajapakse ,  Harold Selnick ,  Shaun Stauffer ,  Joseph Vacca ,  Shawn Stachel ,  Craig Coburn ,  Matthew Stanton

发明人： James Barrow ,  Georgia McGaughey ,  Philippe Nantermet ,  Hemaka Rajapakse ,  Harold Selnick ,  Shaun Stauffer ,  Joseph Vacca ,  Shawn Stachel ,  Craig Coburn ,  Matthew Stanton

IPC分类号： A61K31/4439 ,  A61P25/28 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

CPC分类号： C07D413/04 ,  C07D401/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

摘要： The present invention is directed to 2,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并可用于治疗其中涉及β-分泌酶的疾病如阿尔茨海默氏病的2,4,6-取代的吡啶衍生物化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。

公开(公告)号：US08567670B2

公开(公告)日：2013-10-29

申请号：US12732349

申请日：2010-03-26

申请人： Michael Stanfield ,  George Tsantes ,  Joseph Vacca

发明人： Michael Stanfield ,  George Tsantes ,  Joseph Vacca

IPC分类号： G06K7/00

CPC分类号： G06Q20/3674 ,  G06Q20/24 ,  G06Q20/341 ,  G06Q20/385 ,  G06Q20/4018 ,  G07F7/10 ,  G07F7/12

摘要： A system and method for providing card verification values for card-not-present transactions is described. In one example, a user's computing device stores single-use CVVs to be provided from a secure wallet. The secure wallet may be software running on the user's computing device. Alternatively, it may be an external device connectable to the user's computing device, which accesses the external device to obtain the single-use CVV.

摘要翻译： 描述了一种用于提供卡不存在交易的卡验证值的系统和方法。 在一个示例中，用户的计算设备存储要从安全钱包提供的一次性CVV。 安全钱包可以是在用户的计算设备上运行的软件。 或者，它可以是可连接到用户的计算设备的外部设备，其访问外部设备以获得一次性CVV。

公开(公告)号：US20100258625A1

公开(公告)日：2010-10-14

申请号：US12732349

申请日：2010-03-26

申请人： Michael Stanfield ,  George Tsantes ,  Joseph Vacca

发明人： Michael Stanfield ,  George Tsantes ,  Joseph Vacca

IPC分类号： G06K5/00

CPC分类号： G06Q20/3674 ,  G06Q20/24 ,  G06Q20/341 ,  G06Q20/385 ,  G06Q20/4018 ,  G07F7/10 ,  G07F7/12

摘要： A system and method for providing card verification values for card-not-present transactions is described. In one example, a user's computing device stores single-use CVVs to be provided from a secure wallet. The secure wallet may be software running on the user's computing device. Alternatively, it may be an external device connectable to the user's computing device, which accesses the external device to obtain the single-use CVV.

摘要翻译： 描述了一种用于提供卡不存在交易的卡验证值的系统和方法。 在一个示例中，用户的计算设备存储要从安全钱包提供的一次性CVV。 安全钱包可以是在用户的计算设备上运行的软件。 或者，它可以是可连接到用户的计算设备的外部设备，其访问外部设备以获得一次性CVV。

公开(公告)号：US20070293497A1

公开(公告)日：2007-12-20

申请号：US11791204

申请日：2005-11-18

申请人： Philippe Nantermet ,  Hemaka Rajapakse ,  Harold Selnick ,  James Barrow ,  Shaun Stauffer ,  Joseph Vacca ,  Keith Moore ,  Shawn Stachel ,  Mattahew Stanton

发明人： Philippe Nantermet ,  Hemaka Rajapakse ,  Harold Selnick ,  James Barrow ,  Shaun Stauffer ,  Joseph Vacca ,  Keith Moore ,  Shawn Stachel ,  Mattahew Stanton

IPC分类号： A61K31/44 ,  A61K31/497 ,  A61K31/5377 ,  A61P25/28 ,  C07D413/14

CPC分类号： C07D413/04 ,  C07D413/14

摘要： The present invention is directed to 2,3,4,6-substituted pyridyl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

摘要翻译： 本发明涉及2,3,4,6-取代的吡啶基衍生物化合物，其是β-分泌酶的抑制剂并且可用于治疗涉及β-分泌酶的疾病，例如阿尔茨海默病 。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。

公开(公告)号：US20060052615A1

公开(公告)日：2006-03-09

申请号：US10534291

申请日：2003-11-06

申请人： Craig Coburn ,  Shawn Stachel ,  Joseph Vacca

发明人： Craig Coburn ,  Shawn Stachel ,  Joseph Vacca

IPC分类号： C07D403/02 ,  C07C255/45

CPC分类号： C07D207/08 ,  C07C255/46 ,  C07C255/57 ,  C07C311/08 ,  C07C2601/02 ,  C07C2601/08 ,  C07D211/22 ,  C07D211/32 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D491/10

摘要： Disclosed are compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.

摘要翻译： 公开了式（I）的化合物，

公开(公告)号：US20070254958A1

公开(公告)日：2007-11-01

申请号：US11579049

申请日：2005-05-09

申请人： Craig Coburn ,  Thomas Steele ,  Joseph Vacca ,  David Annis Jr ,  Gergely Makara ,  Huw Nash ,  Praveen Tadikonda ,  Tong Wang

发明人： Craig Coburn ,  Thomas Steele ,  Joseph Vacca ,  David Annis Jr ,  Gergely Makara ,  Huw Nash ,  Praveen Tadikonda ,  Tong Wang

IPC分类号： A61K31/16 ,  A61P25/28 ,  C07C233/05

CPC分类号： C07C235/84 ,  C07C255/57 ,  C07C309/67

摘要： The present invention is directed to phenyl carboxamide compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并且可用于治疗其中涉及β-分泌酶的疾病如阿尔茨海默氏病的苯甲酰胺化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。

公开(公告)号：US20070155744A1

公开(公告)日：2007-07-05

申请号：US10587330

申请日：2005-01-26

申请人： Philip Jones ,  Peter Williams ,  Matthew Morrissette ,  Michelle Kuo ,  Joseph Vacca

发明人： Philip Jones ,  Peter Williams ,  Matthew Morrissette ,  Michelle Kuo ,  Joseph Vacca

IPC分类号： A61K31/5377 ,  A61K31/513 ,  A61K31/497 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/444 ,  C07D413/14 ,  C07D403/14 ,  C07D401/14

CPC分类号： C07D213/64 ,  C07D213/69 ,  C07D213/81 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： N-Benzyl-dihydroxypyridine carboxamide compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dihydroxypyridine carboxamides are of Formula (I) wherein Q is Formula (II) or Formula (III); T is Formula (IV); and R1, R2, X1,X2,X3, and Y1 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

摘要翻译： N-苄基 - 二羟基吡啶甲酰胺化合物是HIV整合酶和HIV复制抑制剂的抑制剂。 在一个实施方案中，二羟基吡啶甲酰胺具有式（I），其中Q为式（II）或式（III）; T为式（Ⅳ）; 和R 1，R 2，X 1，X 2，X 3，X 3， 和Y 1'在本文中定义。 这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。 这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

公开(公告)号：US20070037784A1

公开(公告)日：2007-02-15

申请号：US10568153

申请日：2004-08-10

申请人： Craig Coburn ,  Shawn Stachel ,  Joseph Vacca

发明人： Craig Coburn ,  Shawn Stachel ,  Joseph Vacca

IPC分类号： A61K31/395 ,  C07D225/04

CPC分类号： C07D267/00 ,  C07D225/08

摘要： The present invention is directed to compounds of formula I which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.

摘要翻译： 本发明涉及作为β-分泌酶的抑制剂并可用于治疗或预防其中涉及β-分泌酶的疾病如阿尔茨海默氏病的式I化合物。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及β-分泌酶的疾病中的用途。

公开(公告)号：US20060264416A1

公开(公告)日：2006-11-23

申请号：US11495123

申请日：2006-07-28

申请人： Craig Coburn ,  Shawn Stachel ,  Joseph Vacca

发明人： Craig Coburn ,  Shawn Stachel ,  Joseph Vacca

IPC分类号： A61K31/4747 ,  C07D491/10

CPC分类号： C07D207/08 ,  C07C255/46 ,  C07C255/57 ,  C07C311/08 ,  C07C2601/02 ,  C07C2601/08 ,  C07D211/22 ,  C07D211/32 ,  C07D211/44 ,  C07D211/46 ,  C07D211/74 ,  C07D491/10

摘要： Disclosed are compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the beta-secretase enzyme is involved.

摘要翻译： 公开了作为β-分泌酶的抑制剂并可用于治疗或预防其中涉及β-分泌酶的疾病（例如阿尔茨海默病）和包含这些化合物的药物组合物的式（I）化合物和 这些化合物和组合物在预防或治疗涉及β-分泌酶的疾病中的应用。