公开(公告)号：US11357806B2

公开(公告)日：2022-06-14

申请号：US15131218

申请日：2016-04-18

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Jing-Rong Wang ,  Jia-Ning Mi ,  Junping Kou ,  Yuwei Han ,  Yingqiong Xu

IPC: A61K36/068 ,  A61K31/133 ,  A61K31/164 ,  A61K31/688 ,  G01N30/34 ,  G01N30/72 ,  B01D15/42 ,  C12Q1/04 ,  G01N33/92 ,  G01N30/00 ,  G01N30/02

Abstract: A method of isolating at least one sphingolipid portion selected from a sphingoid base portion, a ceramide portion, a glycosphingolipid portion or a phosphosphingolipid portion from Cordyceps, in particular from wild-type Cordyceps, allows for obtaining sphingolipid portions having an increased amount of one of sphingoid bases, ceramides, glycosphingolipids or phosphosphingolipids. The sphingolipid portions isolated contained significant amounts of sphingolipids not reported so far, and possess exceptional immunosuppressive activities. A method of treating a subject suffering from an inflammatory disease like an autoimmune disease or an allergic disease includes administering sphingolipids isolated from Cordyceps, in particular from wild-type Cordyceps. A method of treating a subject suffering from an inflammatory disease includes administering certain sphingolipids to the subject. Still further in accordance with the present invention is a composition, in particular a pharmaceutical composition comprising at least one sphingolipid portion.

公开(公告)号：US20170128507A1

公开(公告)日：2017-05-11

申请号：US15131218

申请日：2016-04-18

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Jing-Rong Wang ,  Jia-Ning Mi ,  Junping Kou ,  Yuwei Han ,  Yingqiong Xu

IPC: A61K36/068 ,  A61K31/164 ,  A61K31/688 ,  A61K31/133

CPC classification number: A61K36/068 ,  A61K31/133 ,  A61K31/164 ,  A61K31/688 ,  A61K2236/333 ,  A61K2236/39 ,  A61K2236/50 ,  A61K2236/53 ,  B01D15/426 ,  C12Q1/04 ,  G01N30/34 ,  G01N30/72 ,  G01N30/7233 ,  G01N33/92 ,  G01N2030/009 ,  G01N2030/027 ,  G01N2333/37 ,  G01N2405/08

Abstract: A method of isolating at least one sphingolipid portion selected from a sphingoid base portion, a ceramide portion, a glycosphingolipid portion or a phosphosphingolipid portion from Cordyceps, in particular from wild-type Cordyceps, allows for obtaining sphingolipid portions having an increased amount of one of sphingoid bases, ceramides, glycosphingolipids or phosphosphingolipids. The sphingolipid portions isolated contained significant amounts of sphingolipids not reported so far, and possess exceptional immunosuppressive activities. A method of treating a subject suffering from an inflammatory disease like an autoimmune disease or an allergic disease includes administering sphingolipids isolated from Cordyceps, in particular from wild-type Cordyceps. A method of treating a subject suffering from an inflammatory disease includes administering certain sphingolipids to the subject. Still further in accordance with the present invention is a composition, in particular a pharmaceutical composition comprising at least one sphingolipid portion.