-
公开(公告)号：US10155721B2
公开(公告)日：2018-12-18
申请号：US15495949
申请日：2017-04-24
Applicant: Macau University of Science and Technology
Inventor： Guo-Yuan Zhu , Zhi-Hong Jiang , Ji Yang , Xiao-Jun Yao , Xin Liu , Jing Fu , Li-Ping Bai , Liang Liu
IPC: C07C237/26 , C07C231/24
Abstract: One example embodiment is a lignanamide that includes a benzo-angular triquinane skeleton. The lignanamide is represented by formula (I) and any derivative of the formula (I), in which R is represented by —OH or —OCH3. Another example embodiment relates to a method of treating neurodegenerative disease by administering the lignanamide of the formula (I) to a person in need thereof.
-
公开(公告)号：US20180334713A1
公开(公告)日：2018-11-22
申请号：US15600957
申请日：2017-05-22
Inventor： Jin-Xiang Chen , Bao-Ping Xie , Gui-Hua Qiu , Pei-Pei Hu , Zhen Liang , Ye-Mei Liang , Bin Sun , Li-Ping Bai , Zhi-Hong Jiang
CPC classification number: C12Q1/6876 , C08G79/00 , C12Q1/6816 , C12Q2563/107
Abstract: A method of preparing a crystalline copper-based coordination polymer comprises preparing a mixture of copper ions and a first quaternized carboxylate pyridyl ligand; adding a second polypyridyl ligand; and forming crystals of a copper-based coordination polymer therefrom. The crystalline copper-based coordination polymer is suitable for providing a sensing platform for detecting the presence of one or more target nucleic acid sequences such as viral RNA, in particular Dengue virus and/or Zika virus RNA with high selectivity and high specificity. A method of detecting at least a first target nucleic acid sequence, in particular from a viral RNA, in particular it is Flavivirus RNA, in a sample is also provided. Further provided is a kit including the crystalline copper-based coordination polymer and an oligonucleotide probe.
-
公开(公告)号：US10759757B2
公开(公告)日：2020-09-01
申请号：US15271368
申请日：2016-09-21
Inventor： Jinxiang Chen , Jianxin Pang , Shuwen Liu , Li-Ping Bai , Zhi-Hong Jiang
IPC: C07D213/80 , A61K49/10 , A61K49/18
Abstract: A method of preparing a crystalline contrast agent for magnetic resonance imaging from a zwitterionic carboxylic pyridyl ligand includes mixing metal ion and the pyridyl ligand and obtaining crystals therefrom. The crystalline contrast agent includes a manganese-organic or gadolinium-organic 3D framework. The crystalline contrast agent is employed in a kit and a pharmaceutically acceptable composition. The method allows for preparing crystalline contrast agents with superior properties with easily available starting materials and with an economic and efficient process. The method allows for preparing crystalline contrast agents with exceptional water-stability and water-solubility, which exhibit high longitudinal relaxivities and with excellent stabilities under physiological conditions and low cytotoxicity. Further provided is a method for in vivo imaging of a subject, in particular a human, comprising administering the crystalline contrast agent to the subject.
-
Patent Agency Ranking
公开(公告)号：US10519500B2
公开(公告)日：2019-12-31
申请号：US15600957
申请日：2017-05-22
Inventor： Jin-Xiang Chen , Bao-Ping Xie , Gui-Hua Qiu , Pei-Pei Hu , Zhen Liang , Ye-Mei Liang , Bin Sun , Li-Ping Bai , Zhi-Hong Jiang
IPC: C12Q1/68 , C08G79/00 , C12Q1/6876
Abstract: A method of preparing a crystalline copper-based coordination polymer comprises preparing a mixture of copper ions and a first quaternized carboxylate pyridyl ligand; adding a second polypyridyl ligand; and forming crystals of a copper-based coordination polymer therefrom. The crystalline copper-based coordination polymer is suitable for providing a sensing platform for detecting the presence of one or more target nucleic acid sequences such as viral RNA, in particular Dengue virus and/or Zika virus RNA with high selectivity and high specificity. A method of detecting at least a first target nucleic acid sequence, in particular from a viral RNA, in particular it is Flavivirus RNA, in a sample is also provided. Further provided is a kit including the crystalline copper-based coordination polymer and an oligonucleotide probe.
-
公开(公告)号：US10260114B2
公开(公告)日：2019-04-16
申请号：US15598434
申请日：2017-05-18
Inventor： Jin-Xiang Chen , Bin Sun , Bao-Ping Xie , Zhi-Hong Jiang , Li-Ping Bai
IPC: C07D213/50 , C12Q1/70 , C12Q1/6818 , C08G79/00
Abstract: The present invention relates in a first aspect to a method of preparing a crystalline lanthanum-carboxylate coordination polymer and the crystalline lanthanum-carboxylate coordination polymer obtained or obtainable by the method. In another aspect of the present invention, also provides a method of detecting a target nucleic acid sequence in a sample.
-
公开(公告)号：US10023594B2
公开(公告)日：2018-07-17
申请号：US15251300
申请日：2016-08-30
Inventor： Jin-Xiang Chen , Bin Sun , Hai-Qing Zhao , Bao-Ping Xie , Li-Ping Bai , Zhi-Hong Jiang
Abstract: A method of preparing a crystalline zwitterionic zinc(II)-carboxylate compound includes the steps of preparing a mixture of zinc(II) ions and a first pyridyl ligand having three carboxylic acid moieties; subjecting the mixture to conditions under which a precipitate is formed; separating the precipitate; adding a solvent and optionally a second pyridyl ligand to the separated precipitate; subjecting the obtained mixture to conditions under which crystals of the zwitterionic zinc(II)-carboxylate compound are formed; and separating the crystals of the zwitterionic zinc(II)-carboxylate compound. Preferably but not exclusively, the crystalline zwitterionic zinc(II)-carboxylate compound essentially consists of at least one 1D coordination polymer. The compounds are suitable for providing a sensing platform for detecting the presence or amount of target nucleic acid, particularly HIV-1 ds-DNA, with specificity, and, thus, a method of detecting a target nucleic acid sequence in a sample and a kit including the compounds and an oligonucleotide probe are also provided.
-
7.发明申请公开(公告)号：US20180078660A1
公开(公告)日：2018-03-22
申请号：US15271368
申请日：2016-09-21
Inventor： Jinxiang Chen , Jianxin Pang , Shuwen Liu , Li-Ping Bai , Zhi-Hong Jiang
IPC: A61K49/10 , C07D213/80
Abstract: A method of preparing a crystalline contrast agent for magnetic resonance imaging from a zwitterionic carboxylic pyridyl ligand includes mixing metal ion and the pyridyl ligand and obtaining crystals therefrom. The crystalline contrast agent includes a manganese-organic or gadolinium-organic 3D framework. The crystalline contrast agent is employed in a kit and a pharmaceutically acceptable composition. The method allows for preparing crystalline contrast agents with superior properties with easily available starting materials and with an economic and efficient process. The method allows for preparing crystalline contrast agents with exceptional water-stability and water-solubility, which exhibit high longitudinal relaxivities and with excellent stabilities under physiological conditions and low cytotoxicity. Further provided is a method for in vivo imaging of a subject, in particular a human, comprising administering the crystalline contrast agent to the subject.
-
公开(公告)号：US20180057512A1
公开(公告)日：2018-03-01
申请号：US15251300
申请日：2016-08-30
Inventor： Jin-Xiang Chen , Bin Sun , Hai-Qing Zhao , Bao-Ping Xie , Li-Ping Bai , Zhi-Hong Jiang
Abstract: A method of preparing a crystalline zwitterionic zinc(II)-carboxylate compound includes the steps of preparing a mixture of zinc(II) ions and a first pyridyl ligand having three carboxylic acid moieties; subjecting the mixture to conditions under which a precipitate is formed; separating the precipitate; adding a solvent and optionally a second pyridyl ligand to the separated precipitate; subjecting the obtained mixture to conditions under which crystals of the zwitterionic zinc(II)-carboxylate compound are formed; and separating the crystals of the zwitterionic zinc(II)-carboxylate compound. Preferably but not exclusively, the crystalline zwitterionic zinc(II)-carboxylate compound essentially consists of at least one 1D coordination polymer. The compounds are suitable for providing a sensing platform for detecting the presence or amount of target nucleic acid, particularly HIV-1 ds-DNA, with specificity, and, thus, a method of detecting a target nucleic acid sequence in a sample and a kit including the compounds and an oligonucleotide probe are also provided.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.022 seconds)
