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    MENINGOCOCCAL VACCINE FORMULATIONS
    1.
    发明申请
    MENINGOCOCCAL VACCINE FORMULATIONS 审中-公开
    MENINGOCOCCAL VACCINE配方

    公开(公告)号：US20100285069A1

    公开(公告)日：2010-11-11

    申请号：US12734185

    申请日：2008-10-17

    申请人： Mario Contorni ,  Jina Kazzaz ,  Derek O'Hagan ,  Manmohan Singh ,  Mildred Ugozzoli

    发明人： Mario Contorni ,  Jina Kazzaz ,  Derek O'Hagan ,  Manmohan Singh ,  Mildred Ugozzoli

    IPC分类号： A61K39/095 ,  A61P37/04

    CPC分类号： A61K39/095 ,  A61K9/107 ,  A61K9/19 ,  A61K2039/55566

    摘要： A dual formulation for vaccines against Neisseria meningitidis serogroup B (‘Men-B’) comprises (i) an oil-in-water emulsion adjuvant and (ii) a Men-B immunogenic component in lyophilised form. The lyophilised Men-B antigens can be reconstituted into liquid adjuvanted form at the time of use ready for administration to a patient. This formulation has been found to give excellent result in terms of both stability and immunogenicity. The lyophilised component can also include one or more conjugated saccharides from N. meningitidis in serogroups A, C, W135 and/or Y.

    摘要翻译： 针对脑膜炎奈瑟氏球菌血清群B（'Men-B'）的疫苗的双重配方包括（i）水包油乳剂佐剂和（ii）冻干形式的Men-B免疫原性组分。 冻干的Men-B抗原可以在使用时重建成液体佐剂形式，准备用于给予患者。 已经发现这种配方在稳定性和免疫原性方面都获得了优异的结果。 冻干组分还可以包含一种或多种血清群A，C，W135和/或Y中脑膜炎奈瑟氏球菌的共轭糖。

    Microemulsions with adsorbed macromolecules and microparticles
    4.
    发明授权
    Microemulsions with adsorbed macromolecules and microparticles 有权
    具有吸附的大分子和微粒的微乳液

    公开(公告)号：US08771747B2

    公开(公告)日：2014-07-08

    申请号：US13618020

    申请日：2012-09-14

    申请人： Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

    发明人： Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

    IPC分类号： A61K9/50 ,  A61K39/39 ,  A61K39/21 ,  A61K9/107 ,  A61K39/29 ,  A61K39/02 ,  A61K39/245 ,  A61K9/16

    CPC分类号： A61K39/39 ,  A61K9/1075 ,  A61K9/167 ,  A61K39/0208 ,  A61K39/21 ,  A61K39/245 ,  A61K39/29 ,  Y02A50/411 ,  Y02A50/471

    摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.

    摘要翻译： 公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。 微粒包含聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等聚合物，并使用阳离子，阴离子或非离子型洗涤剂形成。 微粒的表面有效吸附生物活性大分子，如DNA，多肽，抗原和佐剂。 还提供了具有可代谢油和乳化剂的油滴乳液的组合物。 还提供了具有免疫刺激量的抗原物质的免疫原性组合物和免疫刺激量的佐剂组合物。 刺激免疫应答的方法，免疫宿主动物免受病毒，细菌或寄生虫感染的方法，以及通过向动物施用微粒的免疫原性组合物和/或增加宿主动物的Th1免疫应答的方法 还提供了本发明的微乳液。

    Microemulsions with adsorbed macromolecules and microparticles
    5.
    发明申请
    Microemulsions with adsorbed macromolecules and microparticles 有权
    具有吸附的大分子和微粒的微乳液

    公开(公告)号：US20070116709A1

    公开(公告)日：2007-05-24

    申请号：US11406144

    申请日：2006-04-18

    申请人： Derek O'Hagan ,  Gary Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

    发明人： Derek O'Hagan ,  Gary Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

    IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K39/145

    CPC分类号： A61K39/39 ,  A61K9/1075 ,  A61K9/167 ,  A61K39/0208 ,  A61K39/21 ,  A61K39/245 ,  A61K39/29 ,  Y02A50/411 ,  Y02A50/471

    摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.

    摘要翻译： 公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。 微粒包含聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等聚合物，并使用阳离子，阴离子或非离子型洗涤剂形成。 微粒的表面有效吸附生物活性大分子，如DNA，多肽，抗原和佐剂。 还提供了具有可代谢油和乳化剂的油滴乳液的组合物。 还提供了具有免疫刺激量的抗原物质的免疫原性组合物和免疫刺激量的佐剂组合物。 刺激免疫应答的方法，免疫宿主动物免受病毒，细菌或寄生虫感染的方法，以及通过向动物施用微粒的免疫原性组合物和/或增加宿主动物的Th1免疫应答的方法 还提供了本发明的微乳液。

    MICROEMULSIONS WITH ADSORBED MACROMOLECULES AND MICROPARTICLES
    6.
    发明申请
    MICROEMULSIONS WITH ADSORBED MACROMOLECULES AND MICROPARTICLES 有权
    具有吸附的大分子和微阵列的微乳液

    公开(公告)号：US20130195923A1

    公开(公告)日：2013-08-01

    申请号：US13618020

    申请日：2012-09-14

    申请人： Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

    发明人： Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

    IPC分类号： A61K9/107 ,  A61K39/39 ,  A61K39/245 ,  A61K39/02 ,  A61K39/21 ,  A61K39/29

    CPC分类号： A61K39/39 ,  A61K9/1075 ,  A61K9/167 ,  A61K39/0208 ,  A61K39/21 ,  A61K39/245 ,  A61K39/29 ,  Y02A50/411 ,  Y02A50/471

    摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.

    摘要翻译： 公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。 微粒包含聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等聚合物，并使用阳离子，阴离子或非离子型洗涤剂形成。 微粒的表面有效吸附生物活性大分子，如DNA，多肽，抗原和佐剂。 还提供了具有可代谢油和乳化剂的油滴乳液的组合物。 还提供了具有免疫刺激量的抗原物质的免疫原性组合物和免疫刺激量的佐剂组合物。 刺激免疫应答的方法，免疫宿主动物免受病毒，细菌或寄生虫感染的方法，以及通过向动物施用微粒的免疫原性组合物和/或增加宿主动物的Th1免疫应答的方法 还提供了本发明的微乳液。

    Microemulsions with adsorbed macromolecules and microparticles
    7.
    发明授权
    Microemulsions with adsorbed macromolecules and microparticles 有权
    具有吸附的大分子和微粒的微乳液

    公开(公告)号：US08309139B2

    公开(公告)日：2012-11-13

    申请号：US11406144

    申请日：2006-04-18

    申请人： Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

    发明人： Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

    IPC分类号： A61K9/50 ,  A61K9/14

    CPC分类号： A61K39/39 ,  A61K9/1075 ,  A61K9/167 ,  A61K39/0208 ,  A61K39/21 ,  A61K39/245 ,  A61K39/29 ,  Y02A50/411 ,  Y02A50/471

    摘要： Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.

    摘要翻译： 公开了具有吸附剂表面的微粒，制备这种微粒的方法及其用途。 微粒包含聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等聚合物，并使用阳离子，阴离子或非离子型洗涤剂形成。 微粒的表面有效吸附生物活性大分子，如DNA，多肽，抗原和佐剂。 还提供了具有可代谢油和乳化剂的油滴乳液的组合物。 还提供了具有免疫刺激量的抗原物质的免疫原性组合物和免疫刺激量的佐剂组合物。 刺激免疫应答的方法，免疫宿主动物免受病毒，细菌或寄生虫感染的方法，以及通过向动物施用微粒的免疫原性组合物和/或增加宿主动物的Th1免疫应答的方法 还提供了本发明的微乳液。

    Microparticles with adsorbed polypeptide-containing molecules
    10.
    发明申请
    Microparticles with adsorbed polypeptide-containing molecules 有权
    具有吸附含多肽的分子的微粒

    公开(公告)号：US20050220883A1

    公开(公告)日：2005-10-06

    申请号：US10505250

    申请日：2003-02-20

    申请人： Derek O'Hagan ,  Manmohan Singh ,  Jina Kazzaz

    发明人： Derek O'Hagan ,  Manmohan Singh ,  Jina Kazzaz

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K39/02 ,  A61K39/12 ,  A61K39/21 ,  A61K39/39 ,  A61K47/48

    CPC分类号： A61K9/1647 ,  A61K9/1676 ,  A61K9/1694 ,  A61K39/02 ,  A61K39/095 ,  A61K39/39 ,  A61K47/6927 ,  A61K2039/55555 ,  A61K2039/6093 ,  C12N2730/10111 ,  C12N2760/16111

    摘要： Microparticles with absorbed polypeptide-containing molecules formed without the use of surfactant, methods of making such microparticle compositions, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like. Preferred polymers are poly(D,L-lactide-co-glycolides), more preferable those having a lactide/glycolide molar ratio ranging from 40:60 to 60:40 and having a molecular weight ranging from 20,000 Daltons to 70,000 Daltons. Preferred polypeptide containing molecules are bacterial and viral antigens (including HIV antigens, meningitis B antigens, streptococcus B antigens, and Influenza A hemagglutinin antigens).

    摘要翻译： 公开了具有不使用表面活性剂形成的含有多肽的分子的微粒，制备这种微粒组合物的方法及其用途。 微粒包括聚合物，例如聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等。 优选的聚合物是聚（D，L-丙交酯 - 共 - 乙交酯），更优选丙交酯/乙交酯摩尔比范围为40:60至60:40且分子量范围为20,000道尔顿至70,000道尔顿的那些。 优选的含多肽分子是细菌和病毒抗原（包括HIV抗原，脑膜炎B抗原，B链球菌抗原和甲型流感血凝素抗原）。