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公开(公告)号：US07622449B2
公开(公告)日：2009-11-24
申请号：US11153192
申请日：2005-06-15
IPC分类号： C07H15/203 , C07H15/26 , A61P9/10 , A61P3/06 , A61K31/7052 , C07D205/08 , A61K31/397
CPC分类号： C07D205/08 , C07H15/26
摘要： This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating and preventing atherosclerosis and atherosclerotic disease events.
摘要翻译： 本发明提供式I的胆固醇吸收抑制剂及其药学上可接受的盐和酯。 该化合物可用于降低血浆胆固醇水平，特别是低密度脂蛋白胆固醇，以及用于治疗和预防动脉粥样硬化和动脉粥样硬化疾病事件。
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2.发明授权Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use 失效二苯基取代的环烷烃，含这些化合物的组合物和使用方法公开(公告)号：US07629467B2
公开(公告)日：2009-12-08
申请号：US10565604
申请日：2004-07-20
申请人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John H. Hutchinson
发明人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John H. Hutchinson
IPC分类号： C07D215/06 , C07D215/12 , C07D215/16 , A61K31/4375
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cyto-protective agents.
摘要翻译： 本发明提供了式（I）化合物，其为5-脂氧合酶活化蛋白抑制剂：式（I）。 式（I）化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。
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公开(公告)号：US06228867B1
公开(公告)日：2001-05-08
申请号：US09275951
申请日：1999-03-25
IPC分类号： A61K31345
CPC分类号： C07D519/00
摘要： There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US6077847A
公开(公告)日：2000-06-20
申请号：US275950
申请日：1999-03-25
IPC分类号： C07D471/04 , A61K31/44
CPC分类号： C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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公开(公告)号：US5985892A
公开(公告)日：1999-11-16
申请号：US275752
申请日：1999-03-25
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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6.发明授权公开(公告)号：US07015235B2
公开(公告)日：2006-03-21
申请号：US10468515
申请日：2002-02-25
申请人： Mark T. Goulet , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Thomas F. Walsh , Daniel Warner , Zhixiong Ye , Jonathan R. Young , Raman K. Bakshi
发明人： Mark T. Goulet , Ravi P. Nargund , Iyassu K. Sebhat , Feroze Ujjainwalla , Thomas F. Walsh , Daniel Warner , Zhixiong Ye , Jonathan R. Young , Raman K. Bakshi
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D491/08 , A61K31/445 , C07D211/62 , C07D211/64 , C07D401/06 , C07D401/14 , C07D413/06 , C07D413/14
摘要： Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
摘要翻译： 某些新的4-取代N-酰化哌啶衍生物是人黑皮质素受体的激动剂，特别是人黑皮质素-4受体（MC-4R）的选择性激动剂。 因此，它们可用于治疗，控制或预防对MC-4R的活化反应的疾病和病症，例如肥胖，糖尿病，性功能障碍，包括勃起功能障碍和女性性功能障碍。
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7.发明授权公开(公告)号：US06818658B2
公开(公告)日：2004-11-16
申请号：US10356879
申请日：2003-02-03
申请人： Feroze Ujjainwalla , Lin Chu , Mark T. Goulet , Bonnie Louridas , Matthew J. Wyvratt , Daniel Warner
发明人： Feroze Ujjainwalla , Lin Chu , Mark T. Goulet , Bonnie Louridas , Matthew J. Wyvratt , Daniel Warner
IPC分类号： A61K31445
CPC分类号： C07D491/08 , A61K31/445 , C07D211/62 , C07D211/64 , C07D401/06 , C07D401/14 , C07D413/06 , C07D413/14
摘要： Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
摘要翻译： 某些新的4-取代的N-酰化哌啶衍生物是人类黑皮质素受体的激动剂，特别是人黑皮质素-4受体（MC-4R）的选择性激动剂。 因此，它们可用于治疗，控制或预防对MC-4R的激活反应的疾病和病症，例如肥胖，糖尿病，性功能障碍，包括勃起功能障碍和女性性功能障碍。
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公开(公告)号：US6110931A
公开(公告)日：2000-08-29
申请号：US276028
申请日：1999-03-25
IPC分类号： A61P5/02 , C07D519/00 , A61K31/437 , A61K31/4375 , C07D471/04 , C07D487/04
CPC分类号： C07D519/00
摘要： There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.
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9.发明申请DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 审中-公开二苯基取代的环己烷，包含这些化合物的组合物和使用方法公开(公告)号：US20100152185A1
公开(公告)日：2010-06-17
申请号：US12632286
申请日：2009-12-07
申请人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight MacDonald , John H. Hutchinson
发明人： Lin Chu , Mark T. Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight MacDonald , John H. Hutchinson
IPC分类号： A61K31/4709 , C07D215/14 , C07D401/12 , C07D413/12 , C07D417/12 , C07D277/64 , A61K31/47 , A61K31/5377 , A61K31/4439 , A61K31/428
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译： 本发明提供了作为5-脂氧合酶活化蛋白抑制剂的式I化合物。 式I的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。
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公开(公告)号：US07012084B2
公开(公告)日：2006-03-14
申请号：US10468517
申请日：2002-02-25
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D413/06 , C07D211/26 , C07D211/28 , C07D211/62 , C07D413/14
摘要： Certain novel 4-substituted N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
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