摘要:
The invention provides an apparatus for transmitting calls generated by a first communication network over a second communication network to a third communication network, the first communication network operating in accordance with a first communication protocol which enables call services, the third communication network operating in accordance with a communication protocol which enables at least one of the call services enabled by the first communication protocol and the second communication network operating according to a second communication protocol different to the first. The apparatus includes means to produce a data message compatible with the second communication protocol indicative of the required service and means to transmit the call and data message over the second communication network to the third communication network, where the data message is read by further apparatus and an appropriate call service established to the third communication network. By providing means to produce a data message compatible with the second protocol to carry the call service information it is possible to establish a call service over a communications network even though that network does not explicitly support the call service.
摘要:
Method and apparatus are provided for transmitting calls generated by a first communication network over a second communication network to a third communication network wherein the first communication network operates in accordance with a first communication protocol which enables call services, the third communication network operates in accordance with a communication protocol which enables at least one of the call services enabled by the first communication protocol and the second communication network operates according to a second communication protocol different from the first. The apparatus includes elements to determine whether a call to be routed from the first communication network to the third communication network by means of the second communication network requires a call service to produce a data message compatible with the second communication protocol indicative of the required service and to transmit the call and data message over the second communication network to the third communication network, where the data message is read and an appropriate call service established to the third communication network. By producing a data message compatible with the second protocol to carry the call service information it is possible to establish a call service over a communications network even though that network does not explicitly support the call service.
摘要:
The invention relates to anti-viral agents of Formula (I) wherein: RA represents OR1, NR1R2, or R1 wherein R1 and R2 independently represent hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; RB represents C(O)R3 wherein R3 represents aryl or heteroaryl; RC represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; RD represents hydrogen and RE represents hydrogen, OR4 or SR4, or RD and RE together with the carbon atom to which they are attached form a carbonyl group or a thiocarbonyl group; when RE is hydrogen, OR4 or SR4, RG and RH are both hydrogen; when RD and RE together with the carbon atom to which they are attached form a carbonyl group or a thiocarbonyl group, RG represents hydrogen and RH represents hydrogen, OR4 or SR4, or RG and RH together with the carbon atom to which they are attached form a carbonyl group or a thiocarbonyl group; R4 represents hydrogen, C1-6alkyl or aryl; when RD and RE together with the carbon atom to which they are attached form a carbonyl group or a thiocarbonyl group, and RG and RH are both hydrogen or RG and RH together with the carbon atom to which they are attached form a carbonyl group or a thiocarbonyl group, then RF represents O, S, NR5 or CR6R7, otherwise RF represents CR6R7; R5 represents hydrogen, C1-6alkyl, arylalkyl or aryl; R6 and R7 independently represent hydrogen, C1-6alkyl, arylalkyl or heteroarylalkyl; RJ represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and enantiomers thereof; provided that when RA is OR1 then R1 is other than tert-butyl. A process for the preparation of compounds of Formula (I) and methods of using them in HCV treatment are provided.
摘要:
Protide compounds of formula (I) wherein X represents H, F, N3, NH2, —CN, or —OMe; X1 represents O or NR7; X2 represents O, NH, NR6 or S, or when X3 is O then X2 is absent; X3 is absent, or when X1 is O then X3 represents O; R1 represents hydrogen; optionally substituted C1-6alkyl; optionally substituted aryl; or optionally substituted heteroaryl; R2 represents hydroxy, OCOR6, or OCO2R6; R3 represents H, optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; R4 and R5 are independently selected from hydrogen, optionally substituted C1-6alkyl, optionally substituted aryl, or optionally substituted aralkyl; R6 represents optionally substituted C1-6alkyl or optionally substituted aryl; R7 represents H, optionally substituted C1-6alkyl, or optionally substituted aryl, wherein when R4 and R7 are each alkyl they may be linked to form a 5- or 6-membered ring; B represents (a), (b), (c), or (d) wherein Z represents O or S; R8 represents H, halo, C2-4alkynyl, trifluoromethyl, C1-3alkoxy, hydroxy, methylthio, amino, nitro, or C1-3alkyl wherein the C1-3alkyl may be optionally substituted by hydroxy, halo, amino, or OR10 wherein R10 represents C1-6alkyl optionally substituted by aryl which may itself be optionally substituted; and R9 represents H, halo, hydroxy, OR6, SR6 or NR3R3; are useful in the treatment of viral infection, particularly HCV infection.
摘要翻译:保护式(I)的化合物,其中X表示H,F,N 3,NH 2,-CN或-OMe; X 1表示O或NR 7; X 2表示O,NH,NR 6或S,或当X 3为O时,X 2不存在; X 3不存在,或当X 1为O时,X 3表示O; R 1表示氢; 任选取代的C 1-6烷基; 任选取代的芳基; 或任选取代的杂芳基; R 2表示羟基,OCOR 6或OCO 2 R 6; R 3表示H,任选取代的C 1-6烷基,任选取代的芳基,任选取代的杂芳基或任选取代的杂环基; R 4和R 5独立地选自氢,任选取代的C 1-6烷基,任选取代的芳基或任选取代的芳烷基; R 6表示任选取代的C 1-6烷基或任选取代的芳基; R 7表示H,任选取代的C 1-6烷基或任选取代的芳基,其中当R 4和R 7各自为烷基时,它们可以连接形成5-或6-元环; B表示(a),(b),(c)或(d)其中Z表示O或S; R 8表示H,卤素,C 2-4炔基,三氟甲基,C 1-3烷氧基,羟基,甲硫基,氨基,硝基或C 1-3烷基,其中C 1-3烷基可任选被羟基,卤素,氨基或OR 其中R 10表示任选被可以被任选取代的芳基取代的C 1-6烷基; 并且R 9表示H,卤素,羟基,OR 6,SR 6或NR 3 R 3; 可用于治疗病毒感染,特别是HCV感染。
摘要:
Novel anti-viral agents of Formula wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R3 wherein R3 is C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; C represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; D represents a saturated or unsaturated optionally substituted 6-membered heterocyclic ring; E represents hydrogen or C1-6-alkyl; F represents hydrogen, C1-6alkyl, aryl or heteroaryl; and G represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof, processes for their preparation and methods of using them in HCV treatment are provided.
摘要:
Novel anti-viral agents of Formula (I) wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R3 wherein R3 is C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; D represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; E represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; F represents hydrogen, C1-6alkyl, aryl or heteroaryl; and G represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts and solvates thereof, processes for their preparation and methods of using them in HCV treatment are provided.
摘要:
Novel antiviral compounds of Formula (I): wherein: A represents hydroxy; R1 represents aryl, heteroaryl bonded through a ring carbon atom, or heterocyclyl bonded through a ring carbon atom, C1-6alkyl or —C5-9cycloalkyl, each of which may be optionally substituted; R2 represents substituted phenyl, or —(CH2)nC5-7cycloalkyl optionally substituted on the cycloalkyl; R3 represents heterocyclyl or heteroaryl; optionally substituted phenyl or optionally substituted —C1-6alkyl; R4 represents hydrogen; and salts, solvates and esters thereof processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.
摘要翻译:式(I)的新型抗病毒化合物:其中:A表示羟基; R 1表示芳基,通过环碳原子键合的杂芳基,或通过环碳原子键合的杂环基,C 1-6烷基或-C 5-9 其各自可以任选被取代; R 2表示取代的苯基或 - 任选地被取代的苯基或 - (CH 2 CH 2)n C 5 - 环烷基 R 3表示杂环基或杂芳基; 任选取代的苯基或任选取代的C 1-6烷基; R 4表示氢; 及其盐,溶剂化物和酯的制备方法,包含它们的药物组合物及其在HCV治疗中的使用方法。
摘要:
The present invention relates to compounds of Formula (I): wherein R1, A, Y, n and m are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of orexin-1 receptor-related disorders and orexin-2 receptor-related disorders. Examples of such disorders are obesity and related disorders such as diabetes type II, dyslipidemia and the metabolic syndrome, cardiovascular diseases such as atherosclerotic vascular disease, angina pectoris, myocardial infarction and stroke, drug addiction, and sleeping disorders.
摘要:
An improved method for removing proppant from fluid used in an oil and gas well for reuse in future operations. The proppant is separated from the well fluid and transported to a materials collection tank. A crane then transports the materials collection tank onto a processing boat. On the processing boat, the proppant is vacuumed from the materials collection tank to a hopper. The proppant is then discharged from the hopper into a holding tank for treatment and reuse. In a first alternative embodiment, two hoppers are positioned above each other so that the proppant can be added to the upper hopper and then fed by gravity to the lower hopper. A valving arrangement maintains vacuum within the interior of at least one hopper at all times to provide a continuous vacuum operation. A conduit discharges from the lower hopper into the holding tank.
摘要:
Novel anti-viral agents of Formula wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R3 wherein R3 is C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; C represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; D represents a saturated or unsaturated optionally substituted 5-membered heterocyclic ring; E represents hydrogen or C1-6alkyl; F represents hydrogen, C1-6alkyl, aryl or heteroaryl; and G represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts and solvates thereof, processes for their preparation and methods of using them in HCV treatment are provided.