公开(公告)号：US10683379B2

公开(公告)日：2020-06-16

申请号：US15078685

申请日：2016-03-23

Applicant: Massachusetts Institute of Technology

Inventor： Daniel Griffith Anderson ,  Eric Andrew Appel ,  Yizhou Dong ,  Robert S. Langer ,  Benjamin C. Tang ,  Omid Veiseh ,  Weiheng Wang ,  Matthew J. Webber ,  Kun Xue

IPC: C08F8/12 ,  C08F8/28 ,  A61K47/32 ,  C08F120/56 ,  C08F120/60 ,  C08F130/06 ,  C08F220/56 ,  C08F220/60 ,  C08F230/06

Abstract: Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.

公开(公告)号：US20180296680A1

公开(公告)日：2018-10-18

申请号：US15765585

申请日：2016-10-06

Applicant: Massachusetts Institute of Technology

Inventor： Matthew J. Webber ,  Eric Andrew Appel ,  Robert S. Langer ,  Daniel Griffith Anderson

IPC: A61K47/54 ,  A61K38/28 ,  A61K47/68 ,  A61K38/26 ,  A61K47/60 ,  C07K16/28

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

公开(公告)号：US20220054642A1

公开(公告)日：2022-02-24

申请号：US17517111

申请日：2021-11-02

Applicant: Massachusetts Institute of Technology

Inventor： Matthew J. Webber ,  Eric Andrew Appel ,  Robert S. Langer ,  Daniel Griffith Anderson

IPC: A61K47/54 ,  A61K47/60 ,  A61K47/34 ,  C07K14/62 ,  C07D519/00 ,  C07K14/605 ,  A61K47/68 ,  A61K38/26 ,  A61K38/28 ,  C07K16/28

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

公开(公告)号：US11191841B2

公开(公告)日：2021-12-07

申请号：US15765585

申请日：2016-10-06

Applicant: Massachusetts Institute of Technology

Inventor： Matthew J. Webber ,  Eric Andrew Appel ,  Robert S. Langer ,  Daniel Griffith Anderson

IPC: A61K47/60 ,  A61K47/34 ,  C07K14/62 ,  C07D519/00 ,  C07K14/605 ,  A61K47/54 ,  A61K47/68 ,  A61K38/26 ,  A61K38/28 ,  C07K16/28

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

公开(公告)号：US20160280827A1

公开(公告)日：2016-09-29

申请号：US15078685

申请日：2016-03-23

Applicant: Massachusetts Institute of Technology

Inventor： Daniel Griffith Anderson ,  Eric Andrew Appel ,  Yizhou Dong ,  Robert S. Langer ,  Benjamin C. Tang ,  Omid Veiseh ,  Weiheng Wang ,  Matthew J. Webber ,  Kun Xue

IPC: C08F230/06 ,  C08F220/54 ,  C08F220/60 ,  A61K47/32

Abstract: Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.

Abstract translation: 通过自由基聚合制备并且可以自组装成聚合物凝胶如水凝胶。 还提供了方法或制备聚合物，涉及聚合物和/或聚合物凝胶或其组合物的试剂盒，用作试剂到受试者的材料或递送应用。