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公开(公告)号：US20150320837A1
公开(公告)日：2015-11-12
申请号：US14652011
申请日：2013-12-12
发明人： Daniel G. Anderson , Hung-Chieh Chou , Matthew J. Webber , Benjamin C. Tang , Yair Levi , Yunlong Zhang , Rosemary Lynn Kanasty , Arturo Jose Vegas , Robert A. Langer
CPC分类号： A61K38/28 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/549 , A61K47/554 , G01N33/66 , G01N33/74 , G01N2333/62
摘要： Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.
摘要翻译： 提供了通过葡萄糖感测胰岛素衍生物“治疗性”，“预防性”或“诊断”（例如葡萄糖介导的胰岛素递送）的“智能”递送的化合物，组合物和方法。 胰岛素衍生物在体内结合血清白蛋白或附聚物。 胰岛素衍生物有效解离以在高血糖状态释放胰岛素，其中葡萄糖与葡萄糖感测元件的络合改变导致胰岛素衍生物的分解导致解离。 化合物，组合物和方法提供了自我调节和长期糖尿病管理的递送策略。
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公开(公告)号：US20180296680A1
公开(公告)日：2018-10-18
申请号：US15765585
申请日：2016-10-06
摘要： The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.
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公开(公告)号：US10683379B2
公开(公告)日：2020-06-16
申请号：US15078685
申请日：2016-03-23
发明人： Daniel Griffith Anderson , Eric Andrew Appel , Yizhou Dong , Robert S. Langer , Benjamin C. Tang , Omid Veiseh , Weiheng Wang , Matthew J. Webber , Kun Xue
IPC分类号： C08F8/12 , C08F8/28 , A61K47/32 , C08F120/56 , C08F120/60 , C08F130/06 , C08F220/56 , C08F220/60 , C08F230/06
摘要： Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.
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公开(公告)号：US20220054642A1
公开(公告)日：2022-02-24
申请号：US17517111
申请日：2021-11-02
IPC分类号： A61K47/54 , A61K47/60 , A61K47/34 , C07K14/62 , C07D519/00 , C07K14/605 , A61K47/68 , A61K38/26 , A61K38/28 , C07K16/28
摘要： The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.
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公开(公告)号：US11191841B2
公开(公告)日：2021-12-07
申请号：US15765585
申请日：2016-10-06
IPC分类号： A61K47/60 , A61K47/34 , C07K14/62 , C07D519/00 , C07K14/605 , A61K47/54 , A61K47/68 , A61K38/26 , A61K38/28 , C07K16/28
摘要： The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.
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公开(公告)号：US20160280827A1
公开(公告)日：2016-09-29
申请号：US15078685
申请日：2016-03-23
发明人： Daniel Griffith Anderson , Eric Andrew Appel , Yizhou Dong , Robert S. Langer , Benjamin C. Tang , Omid Veiseh , Weiheng Wang , Matthew J. Webber , Kun Xue
IPC分类号： C08F230/06 , C08F220/54 , C08F220/60 , A61K47/32
摘要： Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.
摘要翻译： 通过自由基聚合制备并且可以自组装成聚合物凝胶如水凝胶。 还提供了方法或制备聚合物，涉及聚合物和/或聚合物凝胶或其组合物的试剂盒，用作试剂到受试者的材料或递送应用。
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