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1.发明授权Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses 有权来自用于非侵入性产前诊断的母体样品的胎儿核酸甲基化富集的方法和组合物公开(公告)号：US08962247B2
公开(公告)日：2015-02-24
申请号：US12727198
申请日：2010-03-18
CPC分类号： C12Q1/6869 , C12Q1/6804 , C12Q1/6806 , C12Q1/6809 , C12Q1/6888 , C12Q2600/16 , C12Q2537/164 , C12Q2522/101 , C12Q2565/501
摘要： Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
摘要翻译： 提供了利用在母亲和胎儿之间差异甲基化的基因组区域来分离，分离或富集胎儿核酸与母体样品的组合物和方法。 本文所述的组合物和方法对于非侵入性产前诊断特别有用，包括检测染色体异型体。
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2.发明申请PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON-INVASIVE PRENATAL DIAGNOSES 审中-公开用于非侵入性临床诊断的材料样品中用于甲基化的核酸的方法和组合物公开(公告)号：US20120277119A1
公开(公告)日：2012-11-01
申请号：US13495975
申请日：2012-06-13
CPC分类号： C12Q1/6883 , C12Q1/6804 , C12Q1/6806 , C12Q1/6809 , C12Q1/6879 , C12Q1/6888 , C12Q2600/154 , G01N33/5308 , G01N2800/385 , C12Q2537/164 , C12Q2522/101 , C12Q2565/501
摘要： Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
摘要翻译： 提供的是使用在母亲和胎儿之间差异甲基化的基因组区域以从母体样品分离，分离或富集胎儿核酸的组合物和方法。 本文描述的组合物和方法可用于非侵入性产前诊断，包括检测染色体异型体。
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3.发明申请PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON INVASIVE PRENATAL DIAGNOSES 有权用于非侵入性预防诊断的材料样品中用于甲基化的含有核酸的甲基化反应的方法和组合物公开(公告)号：US20100273165A1
公开(公告)日：2010-10-28
申请号：US12727198
申请日：2010-03-18
CPC分类号： C12Q1/6869 , C12Q1/6804 , C12Q1/6806 , C12Q1/6809 , C12Q1/6888 , C12Q2600/16 , C12Q2537/164 , C12Q2522/101 , C12Q2565/501
摘要： Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
摘要翻译： 提供了利用在母亲和胎儿之间差异甲基化的基因组区域来分离，分离或富集胎儿核酸与母体样品的组合物和方法。 本文所述的组合物和方法对于非侵入性产前诊断特别有用，包括检测染色体异型体。
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4.发明授权Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses 有权用于非侵入性产前诊断的母体样品的甲基化酸富集的胎儿核酸的方法和组合物公开(公告)号：US08476013B2
公开(公告)日：2013-07-02
申请号：US12561241
申请日：2009-09-16
CPC分类号： C12Q1/6883 , C12Q1/6804 , C12Q1/6806 , C12Q1/6809 , C12Q1/6879 , C12Q1/6888 , C12Q2600/154 , G01N33/5308 , G01N2800/385 , C12Q2537/164 , C12Q2522/101 , C12Q2565/501
摘要： Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
摘要翻译： 提供的是使用在母亲和胎儿之间差异甲基化的基因组区域以从母体样品分离，分离或富集胎儿核酸的组合物和方法。 本文描述的组合物和方法可用于非侵入性产前诊断，包括检测染色体异型体。
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公开(公告)号：US20130143211A1
公开(公告)日：2013-06-06
申请号：US13517508
申请日：2012-06-13
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6804 , C12Q1/6806 , C12Q1/6809 , C12Q1/6879 , C12Q1/6888 , C12Q2600/154 , G01N33/5308 , G01N2800/385 , C12Q2537/164 , C12Q2522/101 , C12Q2565/501
摘要： Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.
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6.发明申请PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON INVASIVE PRENATAL DIAGNOSES 有权用于非侵入性预防诊断的材料样品中用于甲基化的含有核酸的甲基化反应的方法和组合物公开(公告)号：US20100105049A1
公开(公告)日：2010-04-29
申请号：US12561241
申请日：2009-09-16
CPC分类号： C12Q1/6883 , C12Q1/6804 , C12Q1/6806 , C12Q1/6809 , C12Q1/6879 , C12Q1/6888 , C12Q2600/154 , G01N33/5308 , G01N2800/385 , C12Q2537/164 , C12Q2522/101 , C12Q2565/501
摘要： Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
摘要翻译： 提供的是使用在母亲和胎儿之间差异甲基化的基因组区域以从母体样品分离，分离或富集胎儿核酸的组合物和方法。 本文描述的组合物和方法可用于非侵入性产前诊断，包括检测染色体异型体。
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