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公开(公告)号：US20060257431A1
公开(公告)日：2006-11-16
申请号：US11450972
申请日：2006-06-09
申请人： Matthew Albert , Nina Bhardwaj , Ralph Steinman , Kayo Inaba , Robert Darnell
发明人： Matthew Albert , Nina Bhardwaj , Ralph Steinman , Kayo Inaba , Robert Darnell
IPC分类号： A61K39/00
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.
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2.发明授权Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权使用凋亡细胞将抗原递送至树突状细胞以诱导或耐受T细胞的方法公开(公告)号：US06602709B1
公开(公告)日：2003-08-05
申请号：US09251896
申请日：1999-02-19
IPC分类号： C12N508
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.
摘要翻译： 本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导抗原特异性细胞毒性T淋巴细胞和T辅助细胞。 本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。 根据本发明，抗原通过凋亡细胞靶向树突细胞，凋亡细胞也可以被修饰以表达非天然抗原以呈递给树突状细胞。 由凋亡细胞引发的树突状细胞能够加工和呈递加工的抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用于疫苗疗法。
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3.发明授权Methods for use of apoptotic cells to deliver antigen to dendritic cells for induction or tolerization of T cells 有权使用凋亡细胞将抗原递送至树突状细胞以诱导或耐受T细胞的方法公开(公告)号：US07989203B2
公开(公告)日：2011-08-02
申请号：US11450972
申请日：2006-06-09
IPC分类号： C12N5/071
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.
摘要翻译： 本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导抗原特异性细胞毒性T淋巴细胞和T辅助细胞。 本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。 根据本发明，抗原通过凋亡细胞靶向树突细胞，凋亡细胞也可以被修饰以表达非天然抗原以呈递给树突状细胞。 由凋亡细胞引发的树突状细胞能够加工和呈递加工的抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用于疫苗疗法。
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公开(公告)号：US07129037B2
公开(公告)日：2006-10-31
申请号：US10014877
申请日：2001-12-11
CPC分类号： A61K39/0008 , A61K39/001 , A61K39/12 , A61K39/145 , A61K39/385 , A61K48/00 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , A61K2039/605 , C12N5/0639 , C12N2501/48 , C12N2760/16134 , Y02A50/412
摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing antigen-specific cytotoxic T lymphocytes and T helper cells. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are targeted to dendritic cells by apoptotic cells which may also be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are primed by the apoptotic cells are capable of processing and presenting the processed antigen and inducing cytotoxic T lymphocyte activity or may also be used in vaccine therapies.
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5.发明授权
公开(公告)号：US5851756A
公开(公告)日：1998-12-22
申请号：US458230
申请日：1995-06-02
申请人： Ralph M. Steinman , Kayo Inaba , Gerold Schuler
发明人： Ralph M. Steinman , Kayo Inaba , Gerold Schuler
IPC分类号： C12N5/10 , A61K35/12 , A61K39/00 , A61P37/00 , C07K14/35 , C12N5/02 , C12N5/0784 , C12N5/00 , C12N5/08 , A01N1/02
CPC分类号： C12N5/0639 , A61K39/0008 , A61K2035/122 , A61K2039/5154 , C12N2501/22 , C12N2501/23 , C12N2501/25
摘要： A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic cell modified antigens or dendritic cells pulsed with antigen, including particulates, which antigen is processed and expressed on the antigen-activated dendritic cell. The novel antigens of the invention may be used as immunogens for vaccines or for the treatment of disease. These antigens may also be used to treat autoimmune diseases such as juvenile diabetes and multiple sclerosis.
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6.发明申请Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens 失效树突细胞前体的体外增殖方法及其产生免疫原的用途公开(公告)号：US20090029469A1
公开(公告)日：2009-01-29
申请号：US12218899
申请日：2008-07-17
申请人： Ralph M. Steinman , Kayo Inaba , Gerold Schuler
发明人： Ralph M. Steinman , Kayo Inaba , Gerold Schuler
IPC分类号： C12N5/00
CPC分类号： C12N5/0639 , A61K39/0008 , A61K2035/122 , A61K2039/5154 , C12N2501/22 , C12N2501/23 , C12N2501/25
摘要： A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic cell modified antigens or dendritic cells pulsed with antigen, including particulates, which antigen is processed and expressed on the antigen-activated dendritic cell. The novel antigens of the invention may be used as immunogens for vaccines or for the treatment of disease. These antigens may also be used to treat autoimmune diseases such as juvenile diabetes and multiple sclerosis.
摘要翻译： 提供了一种用于产生树突状细胞前体的增殖培养物的方法。 还提供了从增殖型树突状细胞前体在培养物中产生成熟树突状细胞的方法。 成熟树突细胞的培养提供了产生由树突状细胞修饰抗原或用抗原脉冲的树突状细胞的新型T细胞依赖性抗原的有效手段，包括微粒，该抗原在抗原活化的树突状细胞上被加工和表达。 本发明的新型抗原可以用作疫苗的免疫原或用于治疗疾病。 这些抗原也可用于治疗自身免疫性疾病，例如幼年型糖尿病和多发性硬化症。
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7.发明授权Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens for treating autoimmune diseases 失效树突状细胞前体的体外增殖方法及其用于产生用于治疗自身免疫疾病的免疫原的用途公开(公告)号：US06475483B1
公开(公告)日：2002-11-05
申请号：US09451511
申请日：1999-11-30
申请人： Ralph M. Steinman , Kayo Inaba , Gerold Schuler
发明人： Ralph M. Steinman , Kayo Inaba , Gerold Schuler
IPC分类号： A01N6300
CPC分类号： C12N5/0639 , A61K39/0008 , A61K2035/122 , A61K2039/5154 , C12N2501/22 , C12N2501/23 , C12N2501/25
摘要： A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic cell modified antigens or dendritic cells pulsed with antigen, including particulates, which antigen is processed and expressed on the antigen-activated dendritic cell. The novel antigens of the invention may be used as immunogens for vaccines or for the treatment of disease. These antigens may also be used to treat autoimmune diseases such as juvenile diabetes and multiple sclerosis.
摘要翻译： 提供了一种用于产生树突状细胞前体的增殖培养物的方法。 还提供了从增殖型树突状细胞前体在培养物中产生成熟树突状细胞的方法。 成熟树突细胞的培养提供了产生由树突状细胞修饰抗原或用抗原脉冲的树突状细胞的新型T细胞依赖性抗原的有效手段，包括微粒，该抗原在抗原活化的树突状细胞上被加工和表达。 本发明的新型抗原可以用作疫苗的免疫原或用于治疗疾病。 这些抗原也可用于治疗自身免疫性疾病，例如幼年型糖尿病和多发性硬化症。
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8.发明授权
公开(公告)号：US5994126A
公开(公告)日：1999-11-30
申请号：US261537
申请日：1994-06-17
申请人： Ralph M. Steinman , Kayo Inaba , Gerold Schuler
发明人： Ralph M. Steinman , Kayo Inaba , Gerold Schuler
CPC分类号： C12N5/0639 , A61K39/0008 , A61K2035/122 , A61K2039/5154 , C12N2501/22 , C12N2501/23 , C12N2501/25
摘要： A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic cell modified antigens or dendritic cells pulsed with antigen, including particulates, which antigen is processed and expressed on the antigen-activated dendritic cell. The novel antigens of the invention may be used as immunogens for vaccines or for the treatment of disease. These antigens may also be used to treat autoimmune diseases such as juvenile diabetes and multiple sclerosis.
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9.发明授权Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens 失效树突细胞前体的体外增殖方法及其产生免疫原的用途公开(公告)号：US07923247B2
公开(公告)日：2011-04-12
申请号：US12218899
申请日：2008-07-17
申请人： Ralph M. Steinman , Kayo Inaba , Gerold Schuler
发明人： Ralph M. Steinman , Kayo Inaba , Gerold Schuler
IPC分类号： C12N5/02
CPC分类号： C12N5/0639 , A61K39/0008 , A61K2035/122 , A61K2039/5154 , C12N2501/22 , C12N2501/23 , C12N2501/25
摘要： A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic cell modified antigens or dendritic cells pulsed with antigen, including particulates, which antigen is processed and expressed on the antigen-activated dendritic cell. The novel antigens of the invention may be used as immunogens for vaccines or for the treatment of disease. These antigens may also be used to treat autoimmune diseases such as juvenile diabetes and multiple sclerosis.
摘要翻译： 提供了一种用于产生树突状细胞前体的增殖培养物的方法。 还提供了从增殖型树突状细胞前体在培养物中产生成熟树突状细胞的方法。 成熟树突细胞的培养提供了产生由树突状细胞修饰抗原或用抗原脉冲的树突状细胞的新型T细胞依赖性抗原的有效手段，包括微粒，该抗原在抗原活化的树突状细胞上被加工和表达。 本发明的新型抗原可以用作疫苗的免疫原或用于治疗疾病。 这些抗原也可用于治疗自身免疫性疾病，例如幼年型糖尿病和多发性硬化症。
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