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    METHODS, SYSTEMS AND REAGENTS FOR IMPROVED IMMUNODETECTION
    2.
    发明申请
    METHODS, SYSTEMS AND REAGENTS FOR IMPROVED IMMUNODETECTION 有权
    用于改进免疫保护的方法，系统和试剂

    公开(公告)号：US20120070845A1

    公开(公告)日：2012-03-22

    申请号：US13302136

    申请日：2011-11-22

    申请人： Chae Gyu Park ,  Ralph M. Steinman

    发明人： Chae Gyu Park ,  Ralph M. Steinman

    IPC分类号： G01N21/64 ,  G01N33/566 ,  C07K16/00

    CPC分类号： C07K16/2851 ,  C07K7/06 ,  C07K7/08 ,  C07K16/44 ,  C07K2317/34 ,  C07K2319/00

    摘要： The instant invention provides methods, systems and reagents for immunodetection involving novel epitope tags and antibodies which recognize these new epitope tags as well as the antibodies which detect the FLAG epitope tag. Fusion proteins comprising the epitope tags, as well as methods of purifying these proteins and kits detecting these proteins are also provided.

    摘要翻译： 本发明提供用于免疫检测的方法，系统和试剂，其涉及识别这些新表位标签的新型表位标签和抗体以及检测FLAG表位标签的抗体。 还提供了包含表位标签的融合蛋白，以及纯化这些蛋白质的方法和检测这些蛋白质的试剂盒。

    Methods, systems and reagents for improved immunodetection
    4.
    发明授权
    Methods, systems and reagents for improved immunodetection 有权
    用于改进免疫检测的方法，系统和试剂

    公开(公告)号：US07943345B2

    公开(公告)日：2011-05-17

    申请号：US11974384

    申请日：2007-10-12

    申请人： Chae Gyu Park ,  Ralph M. Steinman

    发明人： Chae Gyu Park ,  Ralph M. Steinman

    IPC分类号： C07K7/08 ,  C12P21/02 ,  C12N15/36

    CPC分类号： C07K16/2851 ,  C07K7/06 ,  C07K7/08 ,  C07K16/44 ,  C07K2317/34 ,  C07K2319/00

    摘要： The instant invention provides methods, systems and reagents for immunodetection involving novel epitope tags and antibodies which recognize these new epitope tags as well as the antibodies which detect the FLAG epitope tag. Fusion proteins comprising the epitope tags, as well as methods of purifying these proteins and kits detecting these proteins are also provided.

    摘要翻译： 本发明提供用于免疫检测的方法，系统和试剂，其涉及识别这些新表位标签的新型表位标签和抗体以及检测FLAG表位标签的抗体。 还提供了包含表位标签的融合蛋白，以及纯化这些蛋白质的方法和检测这些蛋白质的试剂盒。

    Methods of use of viral vectors to deliver antigen to dendritic cells
    6.
    发明授权
    Methods of use of viral vectors to deliver antigen to dendritic cells 失效
    使用病毒载体将抗原递送至树突状细胞的方法

    公开(公告)号：US06300090B1

    公开(公告)日：2001-10-09

    申请号：US08693586

    申请日：1996-08-01

    申请人： Ralph M. Steinman ,  Nina Bhardwaj

    发明人： Ralph M. Steinman ,  Nina Bhardwaj

    IPC分类号： G01N3353

    CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5154 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/57 ,  C12N15/86 ,  C12N2760/16043 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16161 ,  Y02A50/412

    摘要： This invention relates to methods and compositions useful for delivering antigens to dendritic cells which are then useful for inducing T antigen specific cytotoxic T lymphocytes. This invention also provides assays for evaluating the activity of cytotoxic T lymphocytes. According to the invention, antigens are provided to dendritic cells using a viral vector such as influenza virus which may be modified to express non-native antigens for presentation to the dendritic cells. The dendritic cells which are infected with the vector are then capable of presenting the antigen and inducing cytotoxic T lymphocyte activity or may also be used as vaccines.

    摘要翻译： 本发明涉及用于将抗原递送至树突状细胞的方法和组合物，其然后可用于诱导T抗原特异性细胞毒性T淋巴细胞。 本发明还提供了用于评估细胞毒性T淋巴细胞活性的测定法。 根据本发明，使用病毒载体如流感病毒将抗原提供给树突状细胞，所述病毒载体可被修饰以表达非天然抗原以呈递至树突状细胞。 然后用载体感染的树突状细胞能够呈递抗原并诱导细胞毒性T淋巴细胞活性，或者也可以用作疫苗。

    Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens
    8.
    发明授权
    Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens 失效
    树突细胞前体的体外增殖方法及其产生免疫原的用途

    公开(公告)号：US07923247B2

    公开(公告)日：2011-04-12

    申请号：US12218899

    申请日：2008-07-17

    申请人： Ralph M. Steinman ,  Kayo Inaba ,  Gerold Schuler

    发明人： Ralph M. Steinman ,  Kayo Inaba ,  Gerold Schuler

    IPC分类号： C12N5/02

    CPC分类号： C12N5/0639 ,  A61K39/0008 ,  A61K2035/122 ,  A61K2039/5154 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/25

    摘要： A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic cell modified antigens or dendritic cells pulsed with antigen, including particulates, which antigen is processed and expressed on the antigen-activated dendritic cell. The novel antigens of the invention may be used as immunogens for vaccines or for the treatment of disease. These antigens may also be used to treat autoimmune diseases such as juvenile diabetes and multiple sclerosis.

    摘要翻译： 提供了一种用于产生树突状细胞前体的增殖培养物的方法。 还提供了从增殖型树突状细胞前体在培养物中产生成熟树突状细胞的方法。 成熟树突细胞的培养提供了产生由树突状细胞修饰抗原或用抗原脉冲的树突状细胞的新型T细胞依赖性抗原的有效手段，包括微粒，该抗原在抗原活化的树突状细胞上被加工和表达。 本发明的新型抗原可以用作疫苗的免疫原或用于治疗疾病。 这些抗原也可用于治疗自身免疫性疾病，例如幼年型糖尿病和多发性硬化症。