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    Treatment of early-stage osteoarthritis
    2.
    发明授权
    Treatment of early-stage osteoarthritis 有权
    治疗早期骨关节炎

    公开(公告)号：US08586533B2

    公开(公告)日：2013-11-19

    申请号：US12638816

    申请日：2009-12-15

    申请人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Chung-Hwan Chen

    发明人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Chung-Hwan Chen

    IPC分类号： A61K38/29 ,  A61K38/22 ,  A61K38/17 ,  A61K38/16

    CPC分类号： A61K38/29

    摘要： A method for treating early-stage osteoarthritis in an animal is provided. The method comprises delivery of a therapeutically effective amount of a parathyroid hormone (PTH) or a PTH derived substance to an affected joint cavity of the patient. Methods for inhibiting articular chondrocytes apoptosis and for inhibiting a degenerative process of articular chondrocytes in an afflicted animal are also provided.

    摘要翻译： 提供了一种治疗动物早期骨关节炎的方法。 该方法包括将治疗有效量的甲状旁腺激素（PTH）或PTH衍生物质递送至患者的受影响的关节腔。 还提供了在受影响的动物中抑制关节软骨细胞凋亡和抑制关节软骨细胞退行过程的方法。

    TREATMENT OF EARLY-STAGE OSTEOARTHRITIS
    3.
    发明申请
    TREATMENT OF EARLY-STAGE OSTEOARTHRITIS 有权
    治疗早期OSTEOARTHRITIS

    公开(公告)号：US20100160229A1

    公开(公告)日：2010-06-24

    申请号：US12638816

    申请日：2009-12-15

    申请人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Chung-Hwan Chen

    发明人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Chung-Hwan Chen

    IPC分类号： A61K38/29 ,  A61P19/02 ,  A61P19/10

    CPC分类号： A61K38/29

    摘要： A method for treating early-stage osteoarthritis in an animal is provided. The method comprises delivery of a therapeutically effective amount of a parathyroid hormone (PTH) or a PTH derived substance to an affected joint cavity of the patient. Methods for inhibiting articular chondrocytes apoptosis and for inhibiting a degenerative process of articular chondrocytes in an afflicted animal are also provided.

    摘要翻译： 提供了一种治疗动物早期骨关节炎的方法。 该方法包括将治疗有效量的甲状旁腺激素（PTH）或PTH衍生物质递送至患者的受影响的关节腔。 还提供了在受影响的动物中抑制关节软骨细胞凋亡和抑制关节软骨细胞退行过程的方法。

    Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres
    5.
    发明授权
    Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres 有权
    从封装的聚（乳酸 - 乙醇酸）微球控释甲状旁腺激素的方法

    公开(公告)号：US08865220B2

    公开(公告)日：2014-10-21

    申请号：US12814955

    申请日：2010-06-14

    申请人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Cherng-Chyi Tzeng ,  Eswaramoorthy Rajalakshmanan

    发明人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Cherng-Chyi Tzeng ,  Eswaramoorthy Rajalakshmanan

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K38/29

    CPC分类号： A61K38/29 ,  A61K9/1647 ,  A61K9/5031

    摘要： The present invention provides a method for producing a controlled release microsphere with mean average size greater than 50 μm, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly(lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.

    摘要翻译： 本发明提供一种制备平均粒径大于50μm的控释微球的方法，包括制备包含含有药学有效量的生物活性多肽的内含水层的油包水（w / o）乳液 具有类似于甲状旁腺激素的活性，以及​​含有聚（乳酸 - 共 - 乙醇酸）（PLGA）的聚合物物质的油层，然后将w / o乳液加入到聚乙烯醇（PVA）水溶液中以形成水 - 水包油（w / o / w）双重乳液，然后解吸油层中的溶剂。 本发明还提供了通过该方法和用途制备的控释微球。

    Method for Controlled Release of Parathyroid Hormone from Encapsulated Poly(Lactic-Glycolic)Acid Microspheres
    6.
    发明申请
    Method for Controlled Release of Parathyroid Hormone from Encapsulated Poly(Lactic-Glycolic)Acid Microspheres 有权
    从包封的聚（乳酸 - 乙醇酸）微球控制释放甲状旁腺激素的方法

    公开(公告)号：US20110305766A1

    公开(公告)日：2011-12-15

    申请号：US12814955

    申请日：2010-06-14

    申请人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Cherng-Chyi Tzeng ,  Eswaramoorthy Rajalakshmanan

    发明人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Cherng-Chyi Tzeng ,  Eswaramoorthy Rajalakshmanan

    IPC分类号： A61K9/14 ,  A61P19/00 ,  A61P19/10 ,  A61K38/29

    CPC分类号： A61K38/29 ,  A61K9/1647 ,  A61K9/5031

    摘要： The present invention provides a method for producing a controlled release microsphere with mean average size greater than 50 μm, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly (lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.

    摘要翻译： 本发明提供一种制备平均粒径大于50μm的控释微球的方法，包括制备包含含有药学有效量的生物活性多肽的内含水层的油包水（w / o）乳液 具有类似于甲状旁腺激素的活性，以及​​含有聚（乳酸 - 共 - 乙醇酸）（PLGA）的聚合物物质的油层，然后将w / o乳液加入到聚乙烯醇（PVA）水溶液中以形成水 - 水包油（w / o / w）双重乳液，然后解吸油层中的溶剂。 本发明还提供了通过该方法和用途制备的控释微球。

    Isoflavone derivatives and pharmaceutical compositions comprising the same
    7.
    发明授权
    Isoflavone derivatives and pharmaceutical compositions comprising the same 有权
    异黄酮衍生物和包含其的药物组合物

    公开(公告)号：US07618998B2

    公开(公告)日：2009-11-17

    申请号：US12241671

    申请日：2008-09-30

    申请人： Cherng-Chyi Tzeng ,  Yeh-Long Chen ,  Gwo-Jaw Wang ,  Mei-Ling Ho ,  Je-Ken Chang ,  Yin-Chih Fu

    发明人： Cherng-Chyi Tzeng ,  Yeh-Long Chen ,  Gwo-Jaw Wang ,  Mei-Ling Ho ,  Je-Ken Chang ,  Yin-Chih Fu

    IPC分类号： A61K31/35

    CPC分类号： C07D407/12 ,  C07D311/36

    摘要： An isoflavone derivative is provided. The isoxazole derivative has following formula: wherein R1 and R2, independently, include C1-C12 alkyl optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy, and R3 includes hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis including an isoflavone derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

    摘要翻译： 提供异黄酮衍生物。 异恶唑衍生物具有下式：其中R1和R2独立地包括任选地被环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基取代的C1-C12烷基，R3包括氢，羟基或任选被 环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基。 本发明还提供了用于治疗骨质疏松症的药物组合物，其包括异黄酮衍生物或其药学上可接受的盐和药学上可接受的载体。