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公开(公告)号：US08663677B2
公开(公告)日：2014-03-04
申请号：US13209213
申请日：2011-08-12
申请人： Yin-Chih Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Hui-Ting Chen , Je-Ken Chang , Cherng-Chyi Tzeng
发明人： Yin-Chih Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Hui-Ting Chen , Je-Ken Chang , Cherng-Chyi Tzeng
IPC分类号： A61K38/18 , A61K31/7088 , A61K47/04 , A61K38/00
CPC分类号： A61K9/1611 , A61K9/113 , A61K9/1623 , A61K9/1647 , A61L27/54 , A61L2300/802 , A61L2430/02
摘要： A controlled release system and manufacturing method is provided. The method comprises providing a first aqueous solution containing a hydrophilic drug and an alkaline agent, providing an organic solution containing a hydrophobic molecule, providing a second aqueous solution containing a hydrophilic surfactant, mixing the first hydrophilic solution with the organic solution to form a first emulsion, and mixing the first emulsion with a second aqueous solution to form a second emulsion containing delayed-release microsphere.
摘要翻译： 提供了控制释放系统和制造方法。 该方法包括提供含有亲水药物和碱性试剂的第一水溶液，提供含有疏水分子的有机溶液，提供含有亲水表面活性剂的第二水溶液，将第一亲水溶液与有机溶液混合以形成第一乳液 并且将第一乳液与第二水溶液混合以形成含有延迟释放微球的第二乳液。
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公开(公告)号：US20110312885A1
公开(公告)日：2011-12-22
申请号：US13209213
申请日：2011-08-12
申请人： Yin-Chih Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Hui-Ting Chen , Je-Ken Chang , Cherng-Chyi Tzeng
发明人： Yin-Chih Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Hui-Ting Chen , Je-Ken Chang , Cherng-Chyi Tzeng
IPC分类号： A61K38/18 , A61K31/7088 , A61K47/04 , A61K38/00
CPC分类号： A61K9/1611 , A61K9/113 , A61K9/1623 , A61K9/1647 , A61L27/54 , A61L2300/802 , A61L2430/02
摘要： A controlled release system and manufacturing method is provided. The method comprises providing a first aqueous solution containing a hydrophilic drug and an alkaline agent, providing an organic solution containing a hydrophobic molecule, providing a second aqueous solution containing a hydrophilic surfactant, mixing the first hydrophilic solution with the organic solution to form a first emulsion, and mixing the first emulsion with a second aqueous solution to form a second emulsion containing delayed-release microsphere.
摘要翻译： 提供了控制释放系统和制造方法。 该方法包括提供含有亲水药物和碱性试剂的第一水溶液，提供含有疏水分子的有机溶液，提供含有亲水表面活性剂的第二水溶液，将第一亲水溶液与有机溶液混合以形成第一乳液 并且将第一乳液与第二水溶液混合以形成含有延迟释放微球的第二乳液。
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3.发明申请METHOD FOR CONTROLLED RELEASE OF PARATHYROID HORMONE FROM CROSS-LINKED HYALURONIC ACID HYDROGEL 有权从交联羟丙酸水合物中控制释放天冬酰胺的方法公开(公告)号：US20130183349A1
公开(公告)日：2013-07-18
申请号：US13349533
申请日：2012-01-12
申请人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
发明人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
摘要： A method for locally controlled release of an effective amount of PTH(1-34) by a hyaluronic acid based hydrogel that can injected intra-articularly for the treatment of osteoarthritis is provided.
摘要翻译： 提供了一种通过可关节内注射用于治疗骨关节炎的透明质酸基水凝胶局部控制释放有效量的PTH（1-34）的方法。
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公开(公告)号：US20110318331A1
公开(公告)日：2011-12-29
申请号：US12825648
申请日：2010-06-29
申请人： Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Cherng-Chyi Tzeng , Je-Ken Chang , Yin-Chih Fu
发明人： Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Cherng-Chyi Tzeng , Je-Ken Chang , Yin-Chih Fu
CPC分类号： C08G63/06 , A61K9/5146 , A61K9/5153 , A61K47/6935 , A61K47/6937 , C08G63/664 , C08G63/6852
摘要： A novel nanoparticle and use thereof were provided in the present invention. In particular, the nanoparticle is used for delivering therapeutic component, such as oligonucleotide and hydrophobic drug.
摘要翻译： 本发明提供了新颖的纳米颗粒及其用途。 特别地，纳米颗粒用于递送治疗成分，例如寡核苷酸和疏水性药物。
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公开(公告)号：US08889828B2
公开(公告)日：2014-11-18
申请号：US13278844
申请日：2011-10-21
申请人： Hui-Ting Chen , Kuang-Chan Hsieh , Je-Ken Chang , Gwo-Jaw Wang , Yin-Chih Fu , Mei-Ling Ho , Cherng-Chyi Tzeng
发明人： Hui-Ting Chen , Kuang-Chan Hsieh , Je-Ken Chang , Gwo-Jaw Wang , Yin-Chih Fu , Mei-Ling Ho , Cherng-Chyi Tzeng
CPC分类号： A61K47/48207 , A61K38/06 , A61K47/595 , C07K5/0815 , C08G69/48 , C08G73/028
摘要： A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.
摘要翻译： 提供了包括式（1A），（1B），（2）和（3）结构的发散确认的一系列肽。 在其中U，G，A，B，R 1，R 2和T如说明书中所定义的式中。 本发明中公开的发散肽的特征在于矿物结合亲和力。
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6.发明授权Method for controlled release of parathyroid hormone from cross-linked hyaluronic acid hydrogel 有权从交联透明质酸水凝胶中控释甲状旁腺激素的方法公开(公告)号：US08883862B2
公开(公告)日：2014-11-11
申请号：US13349533
申请日：2012-01-12
申请人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
发明人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
摘要： A method for locally controlled release of an effective amount of PTH(1-34) by a hyaluronic acid based hydrogel that can injected intra-articularly for the treatment of osteoarthritis is provided.
摘要翻译： 提供了一种通过可关节内注射用于治疗骨关节炎的透明质酸基水凝胶局部控制释放有效量的PTH（1-34）的方法。
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公开(公告)号：US20120270811A1
公开(公告)日：2012-10-25
申请号：US13278844
申请日：2011-10-21
申请人： Hui-Ting Chen , Kuang-Chan Hsieh , Je-Ken Chang , Gwo-Jaw Wang , Yin-Chih Fu , Mei-Ling Ho , Cherng-Chyi Tzeng
发明人： Hui-Ting Chen , Kuang-Chan Hsieh , Je-Ken Chang , Gwo-Jaw Wang , Yin-Chih Fu , Mei-Ling Ho , Cherng-Chyi Tzeng
IPC分类号： A61K38/06 , A61K38/08 , A61K38/10 , C07K14/00 , C07K5/09 , C07K5/11 , C07K7/06 , C07K7/08 , A61K38/07 , A61K38/16
CPC分类号： A61K47/48207 , A61K38/06 , A61K47/595 , C07K5/0815 , C08G69/48 , C08G73/028
摘要： A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.
摘要翻译： 提供了包括式（1A），（1B），（2）和（3）结构的发散确认的一系列肽。 在其中U，G，A，B，R 1，R 2和T如说明书中所定义的式中。 本发明中公开的发散肽的特征在于矿物结合亲和力。
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公开(公告)号：US20080220070A1
公开(公告)日：2008-09-11
申请号：US11902312
申请日：2007-09-20
申请人： Yin-Chih Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Hui-Ting Chen , Jen-Ken Chang , Cherng-Chyi Tzeng
发明人： Yin-Chih Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Hui-Ting Chen , Jen-Ken Chang , Cherng-Chyi Tzeng
CPC分类号： A61K9/0017 , A61K9/1611 , A61K9/1623 , A61K9/1647 , A61K9/19
摘要： A controlled release system and manufacturing method thereof. The method comprises providing a first aqueous solution containing a hydrophilic drug and an alkaline agent, providing an organic solution containing a hydrophobic molecule, providing a second aqueous solution containing a hydrophilic surfactant, mixing the first hydrophilic solution with the organic solution to form a first emulsion, and mixing the first emulsion with a second aqueous solution to form a second emulsion containing delayed-release microsphere.
摘要翻译： 控制释放系统及其制造方法。 该方法包括提供含有亲水药物和碱性试剂的第一水溶液，提供含有疏水分子的有机溶液，提供含有亲水表面活性剂的第二水溶液，将第一亲水溶液与有机溶液混合以形成第一乳液 并且将第一乳液与第二水溶液混合以形成含有延迟释放微球的第二乳液。
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9.发明授权公开(公告)号：US08138184B2
公开(公告)日：2012-03-20
申请号：US12243376
申请日：2008-10-01
申请人： Cherng-Chyi Tzeng , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
发明人： Cherng-Chyi Tzeng , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
IPC分类号： A61K31/5377 , A61K31/4525 , A61K31/42 , C07D413/02 , C07D413/12 , C07D261/06
CPC分类号： C07D261/08
摘要： An isoxazole derivative is provided. The isoxazole derivative has following formula: wherein R1, R2, R3, R4 and R5, independently, include hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis and cancer including an isoxazole derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
摘要翻译： 提供异恶唑衍生物。 异恶唑衍生物具有下式：其中R 1，R 2，R 3，R 4和R 5独立地包括任选被环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基取代的氢，羟基或C 1 -C 12烷氧基。 本发明还提供了用于治疗骨质疏松症和癌症的药物组合物，包括异恶唑衍生物或其药学上可接受的盐和药学上可接受的载体。
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公开(公告)号：US20130171197A1
公开(公告)日：2013-07-04
申请号：US13338800
申请日：2011-12-28
申请人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Chau-Zen Wang
发明人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Chau-Zen Wang
CPC分类号： C12N5/0068 , A61K47/36 , C12N5/0667 , C12N2533/40 , C12N2533/80 , C12N2537/10
摘要： The present invention provides a hydrogel comprising a poly(N-isopropylacrylamide) cross-linked hyaluronic acid. The present invention also provides a method of synthesizing a hydrogel comprising poly(N-isopropylacrylamide) cross-linked hyaluronic acid, which comprises (a) synthesizing methacrylated hyaluronic acid; and (b) copolymerizing methacrylated hyaluronic acid with N-isopropylacrylamide.
摘要翻译： 本发明提供包含聚（N-异丙基丙烯酰胺）交联透明质酸的水凝胶。 本发明还提供一种合成包含聚（N-异丙基丙烯酰胺）交联透明质酸的水凝胶的方法，其包括（a）合成甲基丙烯酸酯化的透明质酸; 和（b）将甲基丙烯酸酯化的透明质酸与N-异丙基丙烯酰胺共聚。
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