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    Isoflavone derivatives and pharmaceutical compositions comprising the same
    2.
    发明授权
    Isoflavone derivatives and pharmaceutical compositions comprising the same 有权
    异黄酮衍生物和包含其的药物组合物

    公开(公告)号：US07618998B2

    公开(公告)日：2009-11-17

    申请号：US12241671

    申请日：2008-09-30

    申请人： Cherng-Chyi Tzeng ,  Yeh-Long Chen ,  Gwo-Jaw Wang ,  Mei-Ling Ho ,  Je-Ken Chang ,  Yin-Chih Fu

    发明人： Cherng-Chyi Tzeng ,  Yeh-Long Chen ,  Gwo-Jaw Wang ,  Mei-Ling Ho ,  Je-Ken Chang ,  Yin-Chih Fu

    IPC分类号： A61K31/35

    CPC分类号： C07D407/12 ,  C07D311/36

    摘要： An isoflavone derivative is provided. The isoxazole derivative has following formula: wherein R1 and R2, independently, include C1-C12 alkyl optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy, and R3 includes hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis including an isoflavone derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

    摘要翻译： 提供异黄酮衍生物。 异恶唑衍生物具有下式：其中R1和R2独立地包括任选地被环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基取代的C1-C12烷基，R3包括氢，羟基或任选被 环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基。 本发明还提供了用于治疗骨质疏松症的药物组合物，其包括异黄酮衍生物或其药学上可接受的盐和药学上可接受的载体。

    Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres
    6.
    发明授权
    Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres 有权
    从封装的聚（乳酸 - 乙醇酸）微球控释甲状旁腺激素的方法

    公开(公告)号：US08865220B2

    公开(公告)日：2014-10-21

    申请号：US12814955

    申请日：2010-06-14

    申请人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Cherng-Chyi Tzeng ,  Eswaramoorthy Rajalakshmanan

    发明人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Cherng-Chyi Tzeng ,  Eswaramoorthy Rajalakshmanan

    IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K38/29

    CPC分类号： A61K38/29 ,  A61K9/1647 ,  A61K9/5031

    摘要： The present invention provides a method for producing a controlled release microsphere with mean average size greater than 50 μm, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly(lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.

    摘要翻译： 本发明提供一种制备平均粒径大于50μm的控释微球的方法，包括制备包含含有药学有效量的生物活性多肽的内含水层的油包水（w / o）乳液 具有类似于甲状旁腺激素的活性，以及​​含有聚（乳酸 - 共 - 乙醇酸）（PLGA）的聚合物物质的油层，然后将w / o乳液加入到聚乙烯醇（PVA）水溶液中以形成水 - 水包油（w / o / w）双重乳液，然后解吸油层中的溶剂。 本发明还提供了通过该方法和用途制备的控释微球。

    Method for Controlled Release of Parathyroid Hormone from Encapsulated Poly(Lactic-Glycolic)Acid Microspheres
    7.
    发明申请
    Method for Controlled Release of Parathyroid Hormone from Encapsulated Poly(Lactic-Glycolic)Acid Microspheres 有权
    从包封的聚（乳酸 - 乙醇酸）微球控制释放甲状旁腺激素的方法

    公开(公告)号：US20110305766A1

    公开(公告)日：2011-12-15

    申请号：US12814955

    申请日：2010-06-14

    申请人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Cherng-Chyi Tzeng ,  Eswaramoorthy Rajalakshmanan

    发明人： Mei-Ling Ho ,  Gwo-Jaw Wang ,  Je-Ken Chang ,  Yin-Chih Fu ,  Cherng-Chyi Tzeng ,  Eswaramoorthy Rajalakshmanan

    IPC分类号： A61K9/14 ,  A61P19/00 ,  A61P19/10 ,  A61K38/29

    CPC分类号： A61K38/29 ,  A61K9/1647 ,  A61K9/5031

    摘要： The present invention provides a method for producing a controlled release microsphere with mean average size greater than 50 μm, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly (lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.

    摘要翻译： 本发明提供一种制备平均粒径大于50μm的控释微球的方法，包括制备包含含有药学有效量的生物活性多肽的内含水层的油包水（w / o）乳液 具有类似于甲状旁腺激素的活性，以及​​含有聚（乳酸 - 共 - 乙醇酸）（PLGA）的聚合物物质的油层，然后将w / o乳液加入到聚乙烯醇（PVA）水溶液中以形成水 - 水包油（w / o / w）双重乳液，然后解吸油层中的溶剂。 本发明还提供了通过该方法和用途制备的控释微球。