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1.发明授权公开(公告)号：US08138184B2
公开(公告)日：2012-03-20
申请号：US12243376
申请日：2008-10-01
申请人： Cherng-Chyi Tzeng , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
发明人： Cherng-Chyi Tzeng , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
IPC分类号： A61K31/5377 , A61K31/4525 , A61K31/42 , C07D413/02 , C07D413/12 , C07D261/06
CPC分类号： C07D261/08
摘要： An isoxazole derivative is provided. The isoxazole derivative has following formula: wherein R1, R2, R3, R4 and R5, independently, include hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis and cancer including an isoxazole derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
摘要翻译： 提供异恶唑衍生物。 异恶唑衍生物具有下式：其中R 1，R 2，R 3，R 4和R 5独立地包括任选被环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基取代的氢，羟基或C 1 -C 12烷氧基。 本发明还提供了用于治疗骨质疏松症和癌症的药物组合物，包括异恶唑衍生物或其药学上可接受的盐和药学上可接受的载体。
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2.发明授权公开(公告)号：US07618998B2
公开(公告)日：2009-11-17
申请号：US12241671
申请日：2008-09-30
申请人： Cherng-Chyi Tzeng , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
发明人： Cherng-Chyi Tzeng , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
IPC分类号： A61K31/35
CPC分类号： C07D407/12 , C07D311/36
摘要： An isoflavone derivative is provided. The isoxazole derivative has following formula: wherein R1 and R2, independently, include C1-C12 alkyl optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy, and R3 includes hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis including an isoflavone derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
摘要翻译： 提供异黄酮衍生物。 异恶唑衍生物具有下式：其中R1和R2独立地包括任选地被环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基取代的C1-C12烷基，R3包括氢，羟基或任选被 环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基。 本发明还提供了用于治疗骨质疏松症的药物组合物，其包括异黄酮衍生物或其药学上可接受的盐和药学上可接受的载体。
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3.发明申请ISOFLAVONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 有权ISOFLAVONE衍生物和包含其的药物组合物公开(公告)号：US20090215767A1
公开(公告)日：2009-08-27
申请号：US12241671
申请日：2008-09-30
申请人： Cherng-Chyi TZENG , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
发明人： Cherng-Chyi TZENG , Yeh-Long Chen , Gwo-Jaw Wang , Mei-Ling Ho , Je-Ken Chang , Yin-Chih Fu
IPC分类号： A61K31/5377 , C07D311/28 , C07D407/02 , C07D409/02 , A61K31/38 , A61K31/353 , A61K31/496 , C07D405/02 , C07D413/12
CPC分类号： C07D407/12 , C07D311/36
摘要： An isoflavone derivative is provided. The isoxazole derivative has following formula: wherein R1 and R2, independently, include C1-C12 alkyl optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy, and R3 includes hydrogen, hydroxy or C1-C12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis including an isoflavone derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
摘要翻译： 提供异黄酮衍生物。 异恶唑衍生物具有下式：其中R1和R2独立地包括任选地被环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基取代的C1-C12烷基，R3包括氢，羟基或任选被 环氧乙烷，硫杂环丁烷，氮丙啶，氨基，环氨基，氨基羟基或环氨基羟基。 本发明还提供了用于治疗骨质疏松症的药物组合物，其包括异黄酮衍生物或其药学上可接受的盐和药学上可接受的载体。
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4.发明申请METHOD FOR CONTROLLED RELEASE OF PARATHYROID HORMONE FROM CROSS-LINKED HYALURONIC ACID HYDROGEL 有权从交联羟丙酸水合物中控制释放天冬酰胺的方法公开(公告)号：US20130183349A1
公开(公告)日：2013-07-18
申请号：US13349533
申请日：2012-01-12
申请人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
发明人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
摘要： A method for locally controlled release of an effective amount of PTH(1-34) by a hyaluronic acid based hydrogel that can injected intra-articularly for the treatment of osteoarthritis is provided.
摘要翻译： 提供了一种通过可关节内注射用于治疗骨关节炎的透明质酸基水凝胶局部控制释放有效量的PTH（1-34）的方法。
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公开(公告)号：US08889828B2
公开(公告)日：2014-11-18
申请号：US13278844
申请日：2011-10-21
申请人： Hui-Ting Chen , Kuang-Chan Hsieh , Je-Ken Chang , Gwo-Jaw Wang , Yin-Chih Fu , Mei-Ling Ho , Cherng-Chyi Tzeng
发明人： Hui-Ting Chen , Kuang-Chan Hsieh , Je-Ken Chang , Gwo-Jaw Wang , Yin-Chih Fu , Mei-Ling Ho , Cherng-Chyi Tzeng
CPC分类号： A61K47/48207 , A61K38/06 , A61K47/595 , C07K5/0815 , C08G69/48 , C08G73/028
摘要： A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.
摘要翻译： 提供了包括式（1A），（1B），（2）和（3）结构的发散确认的一系列肽。 在其中U，G，A，B，R 1，R 2和T如说明书中所定义的式中。 本发明中公开的发散肽的特征在于矿物结合亲和力。
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公开(公告)号：US08663677B2
公开(公告)日：2014-03-04
申请号：US13209213
申请日：2011-08-12
申请人： Yin-Chih Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Hui-Ting Chen , Je-Ken Chang , Cherng-Chyi Tzeng
发明人： Yin-Chih Fu , Chih-Kuang Wang , Gwo-Jaw Wang , Mei-Ling Ho , Hui-Ting Chen , Je-Ken Chang , Cherng-Chyi Tzeng
IPC分类号： A61K38/18 , A61K31/7088 , A61K47/04 , A61K38/00
CPC分类号： A61K9/1611 , A61K9/113 , A61K9/1623 , A61K9/1647 , A61L27/54 , A61L2300/802 , A61L2430/02
摘要： A controlled release system and manufacturing method is provided. The method comprises providing a first aqueous solution containing a hydrophilic drug and an alkaline agent, providing an organic solution containing a hydrophobic molecule, providing a second aqueous solution containing a hydrophilic surfactant, mixing the first hydrophilic solution with the organic solution to form a first emulsion, and mixing the first emulsion with a second aqueous solution to form a second emulsion containing delayed-release microsphere.
摘要翻译： 提供了控制释放系统和制造方法。 该方法包括提供含有亲水药物和碱性试剂的第一水溶液，提供含有疏水分子的有机溶液，提供含有亲水表面活性剂的第二水溶液，将第一亲水溶液与有机溶液混合以形成第一乳液 并且将第一乳液与第二水溶液混合以形成含有延迟释放微球的第二乳液。
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公开(公告)号：US20130171197A1
公开(公告)日：2013-07-04
申请号：US13338800
申请日：2011-12-28
申请人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Chau-Zen Wang
发明人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Chau-Zen Wang
CPC分类号： C12N5/0068 , A61K47/36 , C12N5/0667 , C12N2533/40 , C12N2533/80 , C12N2537/10
摘要： The present invention provides a hydrogel comprising a poly(N-isopropylacrylamide) cross-linked hyaluronic acid. The present invention also provides a method of synthesizing a hydrogel comprising poly(N-isopropylacrylamide) cross-linked hyaluronic acid, which comprises (a) synthesizing methacrylated hyaluronic acid; and (b) copolymerizing methacrylated hyaluronic acid with N-isopropylacrylamide.
摘要翻译： 本发明提供包含聚（N-异丙基丙烯酰胺）交联透明质酸的水凝胶。 本发明还提供一种合成包含聚（N-异丙基丙烯酰胺）交联透明质酸的水凝胶的方法，其包括（a）合成甲基丙烯酸酯化的透明质酸; 和（b）将甲基丙烯酸酯化的透明质酸与N-异丙基丙烯酰胺共聚。
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8.发明授权Method for controlled release of parathyroid hormone from cross-linked hyaluronic acid hydrogel 有权从交联透明质酸水凝胶中控释甲状旁腺激素的方法公开(公告)号：US08883862B2
公开(公告)日：2014-11-11
申请号：US13349533
申请日：2012-01-12
申请人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
发明人： Mei-Ling Ho , Rajalakshmanan Eswaramoorthy , Shun-Cheng Wu , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Hui-Ting Chen , Yao-Hsien Wang
摘要： A method for locally controlled release of an effective amount of PTH(1-34) by a hyaluronic acid based hydrogel that can injected intra-articularly for the treatment of osteoarthritis is provided.
摘要翻译： 提供了一种通过可关节内注射用于治疗骨关节炎的透明质酸基水凝胶局部控制释放有效量的PTH（1-34）的方法。
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9.发明授权Method for controlled release of parathyroid hormone from encapsulated poly(lactic-glycolic)acid microspheres 有权从封装的聚（乳酸 - 乙醇酸）微球控释甲状旁腺激素的方法公开(公告)号：US08865220B2
公开(公告)日：2014-10-21
申请号：US12814955
申请日：2010-06-14
申请人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Eswaramoorthy Rajalakshmanan
发明人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Eswaramoorthy Rajalakshmanan
CPC分类号： A61K38/29 , A61K9/1647 , A61K9/5031
摘要： The present invention provides a method for producing a controlled release microsphere with mean average size greater than 50 μm, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly(lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.
摘要翻译： 本发明提供一种制备平均粒径大于50μm的控释微球的方法，包括制备包含含有药学有效量的生物活性多肽的内含水层的油包水（w / o）乳液 具有类似于甲状旁腺激素的活性，以及含有聚（乳酸 - 共 - 乙醇酸）（PLGA）的聚合物物质的油层，然后将w / o乳液加入到聚乙烯醇（PVA）水溶液中以形成水 - 水包油（w / o / w）双重乳液，然后解吸油层中的溶剂。 本发明还提供了通过该方法和用途制备的控释微球。
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10.发明申请Method for Controlled Release of Parathyroid Hormone from Encapsulated Poly(Lactic-Glycolic)Acid Microspheres 有权从包封的聚（乳酸 - 乙醇酸）微球控制释放甲状旁腺激素的方法公开(公告)号：US20110305766A1
公开(公告)日：2011-12-15
申请号：US12814955
申请日：2010-06-14
申请人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Eswaramoorthy Rajalakshmanan
发明人： Mei-Ling Ho , Gwo-Jaw Wang , Je-Ken Chang , Yin-Chih Fu , Cherng-Chyi Tzeng , Eswaramoorthy Rajalakshmanan
CPC分类号： A61K38/29 , A61K9/1647 , A61K9/5031
摘要： The present invention provides a method for producing a controlled release microsphere with mean average size greater than 50 μm, comprising preparing a water-in-oil (w/o) emulsion comprising an inner aqueous layer containing a pharmaceutically effective amount of a biologically active polypeptide with activity similar to parathyroid hormone, and an oil layer containing a polymer substance of poly (lactic-co-glycolic acid) (PLGA), then adding the w/o emulsion into aqueous polyvinyl alcohol (PVA) solution to form a water-in-oil-in-water (w/o/w) double emulsion and then desorbing the solvent in the oil layer. The present invention also provides a controlled release microsphere prepared by the method and use thereof.
摘要翻译： 本发明提供一种制备平均粒径大于50μm的控释微球的方法，包括制备包含含有药学有效量的生物活性多肽的内含水层的油包水（w / o）乳液 具有类似于甲状旁腺激素的活性，以及含有聚（乳酸 - 共 - 乙醇酸）（PLGA）的聚合物物质的油层，然后将w / o乳液加入到聚乙烯醇（PVA）水溶液中以形成水 - 水包油（w / o / w）双重乳液，然后解吸油层中的溶剂。 本发明还提供了通过该方法和用途制备的控释微球。
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