公开(公告)号：US20020086335A1

公开(公告)日：2002-07-04

申请号：US10007526

申请日：2001-12-05

Applicant: Meso Scale Technology LLP

Inventor： Richard J. Massey ,  Mark T. Martin ,  Liwen Dong ,  Ming Lu ,  Alan Fischer ,  Fabian Jameison ,  Pam Liang ,  Robert Hoch ,  Jonathan K. Leland

IPC: G01N033/53 ,  C12N009/00 ,  G01F001/64 ,  G01N027/26

CPC classification number: C01B31/0213 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/152 ,  C01B32/174 ,  C01B2202/34 ,  C01B2202/36 ,  C07K17/06 ,  D01F9/12 ,  D01F11/14 ,  G01N21/69 ,  G01N21/76 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/582 ,  G01N2030/8863 ,  G11C13/025 ,  H01M4/60 ,  Y10S435/968 ,  Y10S436/805 ,  Y10S436/806 ,  Y10S977/737 ,  Y10S977/742

Abstract: Graphitic nanotubes, which include tubular fullerenes (commonly called nullbuckytubesnull) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.

公开(公告)号：US20030003460A1

公开(公告)日：2003-01-02

申请号：US09896962

申请日：2001-06-29

Applicant: Meso Scale Technology LLP

Inventor： George B. Sigal ,  Jacob N. Wohlstadter ,  Satyanarayana Gudibande ,  Mark T. Martin ,  James L. Wilbur

IPC: C12Q001/68 ,  G01N033/551

CPC classification number: G01N33/54346 ,  B82Y30/00 ,  C07B2200/11 ,  C07H21/00 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6834 ,  G01N33/532 ,  G01N33/533 ,  G01N33/54306 ,  G01N33/54366 ,  G01N33/5438 ,  G01N33/552 ,  G01N33/553 ,  G01N33/582 ,  G01N33/587 ,  G01N2458/30 ,  C12Q2563/149 ,  C12Q2563/113 ,  C12Q2537/125

Abstract: The present invention relates to methods, reagents and compositions for conducting electrochemiluminescence binding assays which improve one or more characteristics of the assay or the instruments used to conduct the assay. The method is achieved using microparticles that include electrically conductive material. The electrically conductive material has one or more copies of an assay ligand immobilized an its outer surface and a plurality of electrochemiluminescent moieties immobilized an its outer surface. The assay ligand may be linked to the electrochemiluminescent moiety.

Abstract translation: 本发明涉及用于进行电化学发光结合测定的方法，试剂和组合物，其改进测定的一个或多个特征或用于进行测定的仪器。 该方法使用包括导电材料的微粒来实现。 导电材料具有固定其外表面的测定配体的一个或多个拷贝和固定其外表面的多个电化学发光部分。 测定配体可以连接到电化学发光部分。