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13 条记录 (耗时 0.018 秒)

    Characterisation of Ageing Effect and Cardiovascular Risk
    1.
    发明申请
    Characterisation of Ageing Effect and Cardiovascular Risk 有权
    老化效应和心血管风险的表征

    公开(公告)号：US20100121203A1

    公开(公告)日：2010-05-13

    申请号：US12525014

    申请日：2008-01-31

    申请人： Michael O'Rourke ,  Dean Winter

    发明人： Michael O'Rourke ,  Dean Winter

    IPC分类号： A61B5/0205 ,  A61B5/024

    CPC分类号： A61B5/021 ,  A61B5/02007 ,  A61B5/026 ,  A61B5/7275 ,  G06F19/00

    摘要： A method of determining ageing effect and cardiovascular risk in a human patient comprising:- (i) measuring the arterial pulse waveform of the patient when the heart is beating regularly, (ii) extracting the frequency dependent components of the pulse waveform, (iii) determining the ratio of the amplitude based value of the first harmonic (H1) to the amplitude based value of a selected higher harmonic to provide an index of arterial ageing, and (iv) Comparing the index to normative values of index of arterial ageing to determine ageing effect and cardiovascular risk. Other methods of calculating the index based on harmonic amplitudes and the phase angle are also disclosed and claimed.

    摘要翻译： 一种确定人类患者的老化效应和心血管风险的方法，包括：（i）当心脏定期跳动时测量患者的动脉脉搏波形，（ii）提取脉搏波形的频率相关分量，（iii） 确定一次谐波（H1）的基于振幅的值与所选高次谐波的基于振幅的值的比率，以提供动脉衰老指数，以及（iv）将指标与动脉衰老指数的标准值进行比较，以确定 老化效应和心血管风险。 还公开并要求保护基于谐波幅度和相位角计算索引的其它方法。

    Characterisation of ageing effect and cardiovascular risk
    2.
    发明授权
    Characterisation of ageing effect and cardiovascular risk 有权
    老化效应和心血管风险的表征

    公开(公告)号：US08435184B2

    公开(公告)日：2013-05-07

    申请号：US12525014

    申请日：2008-01-31

    申请人： Michael O'Rourke ,  Dean Winter

    发明人： Michael O'Rourke ,  Dean Winter

    IPC分类号： A61B5/02

    CPC分类号： A61B5/021 ,  A61B5/02007 ,  A61B5/026 ,  A61B5/7275 ,  G06F19/00

    摘要： A method of determining ageing effect and cardiovascular risk in a human patient comprising: - (i) measuring the arterial pulse waveform of the patient when the heart is beating regularly, (ii) extracting the frequency dependent components of the pulse waveform, (iii) determining the ratio of the amplitude based value of the first harmonic (H1) to the amplitude based value of a selected higher harmonic to provide an index of arterial ageing, and (iv) Comparing the index to normative values of index of arterial ageing to determine ageing effect and cardiovascular risk. Other methods of calculating the index based on harmonic amplitudes and the phase angle are also disclosed and claimed.

    摘要翻译： 一种确定人类患者的老化效应和心血管风险的方法，包括：（i）当心脏定期跳动时测量患者的动脉脉搏波形，（ii）提取脉搏波形的频率相关分量，（iii） 确定一次谐波（H1）的基于振幅的值与所选高次谐波的基于振幅的值的比率，以提供动脉衰老指数，以及（iv）将指标与动脉衰老指数的标准值进行比较，以确定 老化效应和心血管风险。 还公开并要求保护基于谐波幅度和相位角计算索引的其它方法。

    Method and apparatus for determination of cardiac output from the arterial pressure pulse waveform
    4.
    发明申请
    Method and apparatus for determination of cardiac output from the arterial pressure pulse waveform 审中-公开
    用于确定来自动脉压脉搏波形的心输出量的方法和装置

    公开(公告)号：US20070197924A1

    公开(公告)日：2007-08-23

    申请号：US10591742

    申请日：2005-03-04

    申请人： Michael O'Rourke

    发明人： Michael O'Rourke

    IPC分类号： A61B5/02

    CPC分类号： A61B5/029 ,  A61B5/021 ,  A61B5/02108 ,  A61B5/026 ,  A61B5/1076 ,  A61B5/7235

    摘要： A method for calculating aortic flow velocity from the directly or indirectly measured arterial, aortic, or carotid pressure and/or diameter waveform in which the reflected component of the pressure wave is excluded and the peak systolic flow velocity V is calculated from the amplitude P1 of the central pressure waveform using the formula (I) where C is the aortic pulse wave velocity.

    摘要翻译： 一种从直接或间接测量的动脉，主动脉或颈动脉压力和/或直径波形计算主动脉血流速度的方法，其中压力波的反射分量被排除，并且峰值收缩流速度V根据 使用公式（I）的中心压力波形，其中C是主动脉脉搏波速度。

    Method to establish contexts for use during automated product configuration
    5.
    发明申请
    Method to establish contexts for use during automated product configuration 失效
    在自动化产品配置期间建立使用上下文的方法

    公开(公告)号：US20060248323A1

    公开(公告)日：2006-11-02

    申请号：US11116623

    申请日：2005-04-28

    申请人： Douglas Ewing ,  Michael O'Rourke ,  Anand Raghavan ,  James Vinson

    发明人： Douglas Ewing ,  Michael O'Rourke ,  Anand Raghavan ,  James Vinson

    IPC分类号： G06F9/00

    CPC分类号： G06F9/44505

    摘要： A method and apparatus for validating a user configuration of a computer system are provided. The method generally includes receiving, through a user interface of a configuration system, a user configuration selection, wherein the user configuration selection modifies the configuration of the computer system. Based on the user configuration selection, one or more contexts in a collection of contexts may be modified. The collection of contexts may be applied to part information for a part of the computer system to determine applicable part information for the modified configuration.

    摘要翻译： 提供一种用于验证计算机系统的用户配置的方法和装置。 该方法通常包括通过配置系统的用户界面接收用户配置选择，其中用户配置选择修改计算机系统的配置。 基于用户配置选择，上下文集合中的一个或多个上下文可以被修改。 上下文的集合可以应用于计算机系统的一部分的部件信息以确定用于修改的配置的适用部件信息。

    Method and Device For Treating a Stiffened Blood Vessel
    6.
    发明申请
    Method and Device For Treating a Stiffened Blood Vessel 审中-公开
    治疗加固血管的方法和装置

    公开(公告)号：US20130226280A1

    公开(公告)日：2013-08-29

    申请号：US13594234

    申请日：2012-08-24

    申请人： Michael O'Rourke

    发明人： Michael O'Rourke

    IPC分类号： A61F2/06

    CPC分类号： A61F2/06

    摘要： A device (100) for treating a stiffened blood vessel comprises a self-supporting, surgically implantable, elongate casing (101) adapted to extend about and restrain a stiffened portion (2) of the blood vessel. The casing (101) defines an elongate cavity (103) for receipt of the stiffened portion (2) of the blood vessel. The cavity (103) has a transverse cross-section with an aspect ratio of greater than one in an unloaded state. The casing (103) is configured such that, upon application of increasing pressure to the casing (101) from within said cavity (103), the casing (103) elastically deforms such that the aspect ratio decreases towards one and the area of the cross-section increases.

    摘要翻译： 用于治疗加强血管的装置（100）包括适于延伸并限制血管的加强部分（2）的自支撑的可手术植入的细长壳体（101）。 壳体（101）限定用于接收血管的加强部分（2）的细长空腔（103）。 空腔（103）在无负载状态下具有纵横比大于1的横截面。 外壳（103）构造成使得当在所述空腔（103）内施加增加的压力到所述壳体（101）时，所述壳体（103）弹性变形，使得所述纵横比朝向所述空腔 部分增加。

    Method and apparatus for determination of central aortic pressure
    8.
    发明申请
    Method and apparatus for determination of central aortic pressure 有权
    用于确定中心主动脉压的方法和装置

    公开(公告)号：US20070185400A1

    公开(公告)日：2007-08-09

    申请号：US10583515

    申请日：2004-12-17

    申请人： Michael O'Rourke

    发明人： Michael O'Rourke

    IPC分类号： A61B5/02

    CPC分类号： A61B5/02116 ,  A61B5/021 ,  A61B5/7239

    摘要： Methods for determining central systolic pressure are disclosed. A first method determines the time of peak in a measured carotid waveform and then determines the pressure in a measured radial waveform at the corresponding time. A second method utilises only a measured radial waveform. The waveform is analysed to determine a time indicative of lower body waveform and determines the pressure at this time. In each case, the determined pressure is substantially the same as the central systolic pressure.

    摘要翻译： 公开了确定中心收缩压的方法。 第一种方法确定测量的颈动脉波形中的峰值时间，然后确定在相应时间的测量的径向波形中的压力。 第二种方法仅使用测量的径向波形。 分析波形以确定表示下半身波形的时间并确定此时的压力。 在每种情况下，所确定的压力基本上与中心收缩压相同。

    Methods of distinguishing between vasoconstriction and vasodiltation as a cause of hypotension
    9.
    发明申请
    Methods of distinguishing between vasoconstriction and vasodiltation as a cause of hypotension 有权
    区分血管收缩和血管扩张作为低血压原因的方法

    公开(公告)号：US20070179384A1

    公开(公告)日：2007-08-02

    申请号：US10591309

    申请日：2005-03-04

    申请人： Michael O'Rourke

    发明人： Michael O'Rourke

    IPC分类号： A61B5/02

    CPC分类号： A61B5/021 ,  A61B5/02108 ,  A61B5/412

    摘要： The present invention relates to the use of the arterial pressure waveform recorded invasively or non-invasively, to distinguish between compensatory vasoconstriction with low cardiac output on the one hand from vasodilation from more severe organ damage on the other, as a cause of hypotension in acute emergencies. The waveforms may be subjected to harmonic analysis and the moduli of their harmonic components compared whereby a hypotensive individual can be confirmed to have the higher the first harmonic is considered as having vasoconstriction as a cause of hypotension.

    摘要翻译： 本发明涉及使用记录为侵入性或非侵入性的动脉压波形来区分代谢性血管收缩与低心输出量，一方面是来自较严重器官损伤的血管舒张，另一方面是急性低血压的原因 紧急情况。 可以对波形进行谐波分析，并且将其谐波分量的模量相比较，由此可以确认低血压个体具有较高的一次谐波被认为具有血管收缩作为低血压的原因。