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1.发明申请SELECTIVELY EXPANDABLE OPERATIVE ELEMENT SUPPORT STRUCTURE AND METHODS OF USE 审中-公开选择性可扩展的操作元素支持结构和使用方法公开(公告)号：US20120239028A1
公开(公告)日：2012-09-20
申请号：US13051738
申请日：2011-03-18
CPC分类号： A61B18/1492 , A61B18/06 , A61B18/082 , A61B18/24 , A61B2018/0016 , A61B2018/0022 , A61B2018/00488 , A61B2018/00577 , A61B2018/0212 , A61B2018/1497 , A61B2018/1861 , A61N7/022
摘要： In one embodiment, a device is provided including an expandable support member having a first portion and a second portion is provided. The first portion is adapted to have a smaller expansion index than the second portion. A therapeutic or diagnostic instrument is supported, at least in part, by the expandable support member first portion. In another embodiment, the support member is adapted for non-uniform expansion of the first and second portions. There are also described methods of forming therapeutic devices. There are also described methods of providing therapy to tissue in a body by positioning a device in proximity to tissue in a body selected to receive therapy. Next, the expandable support member second portion is expanded until the instrument is at a therapeutic position relative to the tissue in a body selected to receive therapy. Thereafter, therapy or diagnosis is provided to the selected tissue using the device.
摘要翻译： 在一个实施例中，提供了包括具有第一部分和第二部分的可扩展支撑构件的装置。 第一部分适于具有比第二部分更小的膨胀指数。 治疗或诊断仪器至少部分由可扩张支撑构件第一部分支撑。 在另一个实施例中，支撑构件适于使第一和第二部分不均匀地膨胀。 还描述了形成治疗装置的方法。 还描述了通过将设备定位在选择用于接受治疗的身体中的组织附近来向身体中的组织提供治疗的方法。 接下来，可扩展支撑构件第二部分被扩张，直到器械相对于选择用于接受治疗的身体中的组织处于治疗位置。 此后，使用该装置向所选择的组织提供治疗或诊断。
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公开(公告)号：US10278774B2
公开(公告)日：2019-05-07
申请号：US13051738
申请日：2011-03-18
IPC分类号： A61B18/12 , A61B18/14 , A61B18/00 , A61N7/02 , A61B18/06 , A61B18/08 , A61B18/24 , A61B18/02 , A61B18/18
摘要： In one embodiment, a device is provided including an expandable support member having a first portion and a second portion is provided. The first portion is adapted to have a smaller expansion index than the second portion. A therapeutic or diagnostic instrument is supported, at least in part, by the expandable support member first portion. In another embodiment, the support member is adapted for non-uniform expansion of the first and second portions. There are also described methods of forming therapeutic devices. There are also described methods of providing therapy to tissue in a body by positioning a device in proximity to tissue in a body selected to receive therapy. Next, the expandable support member second portion is expanded until the instrument is at a therapeutic position relative to the tissue in a body selected to receive therapy. Thereafter, therapy or diagnosis is provided to the selected tissue using the device.
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3.发明授权公开(公告)号：US08439908B2
公开(公告)日：2013-05-14
申请号：US12167931
申请日：2008-07-03
CPC分类号： A61B18/1485 , A61B18/0218 , A61B18/1492 , A61B2017/22069 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00482 , A61B2018/00494 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00738 , A61B2018/00791 , A61B2018/00875 , A61B2018/00898 , A61B2018/0262 , A61B2018/124 , A61B2018/1497
摘要： Devices and methods are provided for the ablation of regions of the digestive tract to achieve hemostasis and to eradicate chronically bleeding lesions as occur with gastric antral vascular ectasia (GAVE), portal hypertensive gastropathy (PHG), radiation proctopathy and colopathy, arteriovenous malformations, and angiodysplasia. Ablation is typically provided in a wide-field manner, and in conjunction with sufficient pressure to achieve coaptive coagulation. Ablation, as provided the invention, starts at the mucosa and penetrates deeper into the gastrointestinal wall in a controlled manner. Ablation control may be exerted by way of electrode design and size, energy density, power density, number of applications, pattern of applications, and pressure. Control may also be provided by a fractional ablation that ablates some tissue within a target region and leaves a portion substantially unaffected. Embodiments of the device include an ablational electrode array that spans 360 degrees and an array that spans an arc of less than 360 degrees.
摘要翻译： 提供了用于消融消化道的设备和方法，以实现止血和根除胃窦血管扩张症（GAVE），门静脉高压性胃病（PHG），放射性原发性病变和病变，动静脉畸形以及 血管发育不良。 通常以广泛的方式提供消融，并结合足够的压力来实现合适的凝血。 根据本发明，消融从粘膜开始并以受控的方式深入胃肠壁。 消融控制可以通过电极设计和尺寸，能量密度，功率密度，应用数量，应用模式和压力来施加。 控制也可以通过消融目标区域内的一些组织并使基本上不受影响的部分的部分消融来提供。 该装置的实施例包括跨越360度的消融电极阵列和跨越小于360度的弧的阵列。
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4.发明申请公开(公告)号：US20090012513A1
公开(公告)日：2009-01-08
申请号：US12167931
申请日：2008-07-03
CPC分类号： A61B18/1485 , A61B18/0218 , A61B18/1492 , A61B2017/22069 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00482 , A61B2018/00494 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00738 , A61B2018/00791 , A61B2018/00875 , A61B2018/00898 , A61B2018/0262 , A61B2018/124 , A61B2018/1497
摘要： Devices and methods are provided for the ablation of regions of the digestive tract to achieve hemostasis and to eradicate chronically bleeding lesions as occur with gastric antral vascular ectasia (GAVE), portal hypertensive gastropathy (PHG), radiation proctopathy and colopathy, arteriovenous malformations, and angiodysplasia. Ablation is typically provided in a wide-field manner, and in conjunction with sufficient pressure to achieve coaptive coagulation. Ablation, as provided the invention, starts at the mucosa and penetrates deeper into the gastrointestinal wall in a controlled manner. Ablation control may be exerted by way of electrode design and size, energy density, power density, number of applications, pattern of applications, and pressure. Control may also be provided by a fractional ablation that ablates some tissue within a target region and leaves a portion substantially unaffected. Embodiments of the device include an ablational electrode array that spans 360 degrees and an array that spans an arc of less than 360 degrees.
摘要翻译： 提供了用于消融消化道的设备和方法，以实现止血和根除胃窦血管扩张症（GAVE），门静脉高压性胃病（PHG），放射性原发性病变和病变，动静脉畸形以及 血管发育不良。 通常以广泛的方式提供消融，并结合足够的压力来实现合适的凝血。 根据本发明，消融从粘膜开始并以受控的方式深入胃肠壁。 消融控制可以通过电极设计和尺寸，能量密度，功率密度，应用数量，应用模式和压力来施加。 控制也可以通过消融目标区域内的一些组织并使基本上不受影响的部分的部分消融来提供。 该装置的实施例包括跨越360度的消融电极阵列和跨越小于360度的弧的阵列。
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5.发明申请ELECTRICAL MEANS TO NORMALIZE ABLATIONAL ENERGY TRANSMISSION TO A LUMINAL TISSUE SURFACE OF VARYING SIZE 有权将能量转移到变化尺寸的发光组织表面的电气手段公开(公告)号：US20080319350A1
公开(公告)日：2008-12-25
申请号：US12143404
申请日：2008-06-20
CPC分类号： A61B18/18 , A61B5/053 , A61B5/0538 , A61B5/1076 , A61B18/0218 , A61B18/082 , A61B18/14 , A61B18/1492 , A61B18/20 , A61B2018/00017 , A61B2018/00214 , A61B2018/0022 , A61B2018/00488 , A61B2018/00577 , A61B2018/00642 , A61B2018/00714 , A61B2018/00755 , A61B2018/00791 , A61B2018/00875 , A61B2562/0257
摘要： Methods and devices for measuring the size of a body lumen and a method for ablating tissue that uses the measurement to normalize delivery of ablational energy from an expandable operative element to a luminal target of varying circumference are provided. The method includes inserting into the lumen an expandable operative element having circuitry with resistivity or inductance that varies according to the circumference of the operative element, varying the expansion of the operative element with an expansion medium, measuring the resistivity of the circuitry, and relating the resistivity or inductance to a value for the circumference of the operative element. In some embodiments the sizing circuit includes a conductive elastomer wrapped around the operative element. Other embodiments of the method apply to operative elements that include an overlapping energy delivery element support in which the overlap varies inversely with respect to the state of expansion, and which is configured with sizing electrodes that sense the amount of the overlap.
摘要翻译： 提供了用于测量体腔尺寸的方法和装置以及用于消融组织的方法和装置，所述方法使用所述测量来将消融能量从可扩张的可操作元件的规则化转变为变化圆周的管腔靶。 该方法包括将具有电阻率或电感的电路的可扩展的操作元件插入到内腔中，所述电路或电感根据操作元件的周长而变化，用膨胀介质改变操作元件的膨胀，测量电路的电阻率， 电阻率或电感值为操作元件圆周的值。 在一些实施例中，施胶电路包括围绕操作元件缠绕的导电弹性体。 该方法的其他实施例适用于包括重叠的能量传递元件支撑件的操作元件，其中重叠相对于膨胀状态反向变化，并且其被配置有感测重叠量的尺寸电极。
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6.发明授权Electrical means to normalize ablational energy transmission to a luminal tissue surface of varying size 有权电气意味着将消融能量传递归一化到不同大小的管腔组织表面公开(公告)号：US08784338B2
公开(公告)日：2014-07-22
申请号：US12143404
申请日：2008-06-20
CPC分类号： A61B18/18 , A61B5/053 , A61B5/0538 , A61B5/1076 , A61B18/0218 , A61B18/082 , A61B18/14 , A61B18/1492 , A61B18/20 , A61B2018/00017 , A61B2018/00214 , A61B2018/0022 , A61B2018/00488 , A61B2018/00577 , A61B2018/00642 , A61B2018/00714 , A61B2018/00755 , A61B2018/00791 , A61B2018/00875 , A61B2562/0257
摘要： Methods and devices for measuring the size of a body lumen and a method for ablating tissue that uses the measurement to normalize delivery of ablational energy from an expandable operative element to a luminal target of varying circumference are provided. The method includes inserting into the lumen an expandable operative element having circuitry with resistivity or inductance that varies according to the circumference of the operative element, varying the expansion of the operative element with an expansion medium, measuring the resistivity of the circuitry, and relating the resistivity or inductance to a value for the circumference of the operative element. In some embodiments the sizing circuit includes a conductive elastomer wrapped around the operative element. Other embodiments of the method apply to operative elements that include an overlapping energy delivery element support in which the overlap varies inversely with respect to the state of expansion, and which is configured with sizing electrodes that sense the amount of the overlap.
摘要翻译： 提供了用于测量体腔尺寸的方法和装置以及用于消融组织的方法和装置，所述方法使用所述测量来将消融能量从可扩张的可操作元件的规则化转变为变化圆周的管腔靶。 该方法包括将具有电阻率或电感的电路的可扩展的操作元件插入到内腔中，所述电路或电感根据操作元件的周长而变化，用膨胀介质改变操作元件的膨胀，测量电路的电阻率， 电阻率或电感值为操作元件圆周的值。 在一些实施例中，施胶电路包括围绕操作元件缠绕的导电弹性体。 该方法的其他实施例适用于包括重叠的能量传递元件支撑件的操作元件，其中重叠相对于膨胀状态反向变化，并且其被配置有感测重叠量的尺寸电极。
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7.发明申请公开(公告)号：US20090318914A1
公开(公告)日：2009-12-24
申请号：US12270373
申请日：2008-11-13
申请人： David S. Utley , Brent C. Gerberding , Miriam H. Taimisto , Winnie Chung , Jennifer D. Marler , Viorica Filimon
发明人： David S. Utley , Brent C. Gerberding , Miriam H. Taimisto , Winnie Chung , Jennifer D. Marler , Viorica Filimon
IPC分类号： A61B18/18
CPC分类号： A61B18/1485 , A61B18/1206 , A61B46/13 , A61B2017/4225 , A61B2018/0016 , A61B2018/00279 , A61B2018/00285 , A61B2018/00291 , A61B2018/00559 , A61B2018/00577 , A61B2018/00642 , A61B2018/00702 , A61B2018/00708 , A61B2018/00738 , A61B2018/00779 , A61B2018/00791 , A61B2018/00875 , A61B2018/00886 , A61B2018/142 , A61B2018/1435 , A61B2018/1497 , A61B2050/314
摘要： The invention provides a system, devices, and methods for ablating abnormal epithelial tissue of the uterine cervix. Embodiments of an ablation device include an operative head with a support surface adapted to conformably engage and therapeutically contact the cervix, and an energy delivery element on the support surface. The energy delivery element is configured to deliver energy, such as RF energy, to the tissue in a manner that controls the surface area and depth of ablation. The device may further include a shaft and a handle to support the ablation device, and may further include a speculum to facilitate access to the cervix. A system to support the operation of the ablation device includes a generator to deliver energy to the energy delivery element. Embodiments of a method for ablating abnormal cervical tissue include inserting an ablation device intravaginally to contact the cervix, aligning an energy delivery element support surface conformably against a region of the cervix with abnormal tissue, and ablating the tissue.
摘要翻译： 本发明提供了一种用于消除子宫颈异常上皮组织的系统，装置和方法。 消融装置的实施例包括具有支承表面的操作头部，该支撑表面适于与子宫颈顺应地接合和治疗接触，以及支撑表面上的能量输送元件。 能量递送元件被配置为以控制消融的表面积和深度的方式将能量（例如RF能量）递送到组织。 该装置还可以包括轴和手柄以支撑消融装置，并且还可包括用于便于接近子宫颈的窥器。 用于支持消融装置的操作的系统包括用于向能量输送元件输送能量的发生器。 用于消除异常宫颈组织的方法的实施方案包括阴道内插入消融装置以接触子宫颈，将能量递送元件支撑表面与宫颈区域顺应对准异常组织，并消融组织。
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公开(公告)号：US08506619B2
公开(公告)日：2013-08-13
申请号：US12836357
申请日：2010-07-14
申请人： John Ortiz , Masoud Molaei , Frank Musbach , Brent C. Gerberding
发明人： John Ortiz , Masoud Molaei , Frank Musbach , Brent C. Gerberding
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2002/823 , A61F2250/0015 , A61F2250/0023 , A61F2250/0048 , D04C1/06
摘要： A stent comprises at least one stent member woven to form a substantially tubular body that defines a flow path. The tubular body comprises a first region and a second region. In the first region the at least one stent member defines a plurality of first region openings and in the second region at least one first portion of the at least one member and at least one second portion of the at least one member are engaged together to form at least one primary strand. The at least one primary strand defines a plurality of second region openings. The at least one of the plurality of second region openings is in fluid communication with the flow path. The plurality of second region openings provide the second region with a greater porosity than the first region.
摘要翻译： 支架包括至少一个编织的支架构件，以形成限定流路的基本上管状的主体。 管状体包括第一区域和第二区域。 在第一区域中，至少一个支架构件限定多个第一区域开口，并且在第二区域中，至少一个构件的至少一个第一部分和至少一个构件的至少一个第二部分接合在一起形成 至少一个主链。 至少一个主股限定了多个第二区域开口。 多个第二区域开口中的至少一个与流动路径流体连通。 多个第二区域开口为第二区域提供比第一区域更大的孔隙率。
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9.发明申请SYSTEM AND METHOD FOR RETAINING VASO-OCCLUSIVE DEVICES WITHIN AN ANEURYSM 有权用于在血管内保留VASO-OCCLUSIVE装置的系统和方法公开(公告)号：US20110196413A1
公开(公告)日：2011-08-11
申请号：US13091608
申请日：2011-04-21
IPC分类号： A61M29/00
CPC分类号： A61F2/06 , A61B17/12022 , A61B17/12113 , A61B17/12172 , A61B2017/12063
摘要： The present invention is directed to systems for occluding an aneurysm having an aneurysmal neck and an aneurysmal inner wall. Generally, a device in accordance with the present invention includes a mesh-like structure that is integrally composed of a shape-memory alloy such as NiTi. The device is deployed within the aneurysm through the aneurysmal neck. The device is configured to be in a deployed state and an undeployed state, and is configured to transition from the undeployed state to the deployed state by exposure to a higher temperature and/or by being unconstrained. The device may function to retain finer vaso-occlusive devices such as vaso-occlusive coils and/or embolic liquids. Furthermore, the device itself may function as a vaso-occlusive device.
摘要翻译： 本发明涉及用于闭塞具有动脉瘤颈和动脉瘤内壁的动脉瘤的系统。 通常，根据本发明的装置包括由诸如NiTi的形状记忆合金整体地组成的网状结构。 该装置通过动脉瘤颈部部署在动脉瘤内。 该设备被配置为处于部署状态和未部署状态，并且被配置为通过暴露于更高的温度和/或通过不受限制地从未部署状态转换到部署状态。 该装置可用于保持更精细的血管闭塞装置，例如血管闭塞线圈和/或栓塞液体。 此外，装置本身可以用作血管闭塞装置。
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公开(公告)号：US06315790B1
公开(公告)日：2001-11-13
申请号：US09327234
申请日：1999-06-07
IPC分类号： A61F1100
CPC分类号： A61F2/958 , A61B90/39 , A61F2002/9583 , A61F2002/9586 , A61F2250/0098
摘要： A stent delivery system which includes a catheter having a radially expandable stent coaxially arranged near a distal end of the catheter. The catheter is equipped with at least one stent securement hub disposed about a portion of the distal end of the catheter underlying the stent. Each of the at least one stent securement hubs being made of a radiopaque polymer.
摘要翻译： 一种支架输送系统，其包括具有在导管的远端附近同轴布置的径向可扩张支架的导管。 该导管配备有至少一个支架固定毂，其设置在支架下方的导管的远端的一部分周围。 所述至少一个支架固定座中的每一个由不透射线的聚合物制成。
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